Comparing the efficacy of PRP vs hyaluronic acid vs placebo injections in the management of supraspinatus tendinopathy; randomized controlled trial

Maged Al Banouby; Alaa-eldin Mohey-eldin Soliman; Hisham Mesbah Soliman; Hazem A. Farouk

doi:10.53730/ijhs.v6nS4.10306

Authors

Maged Al Banouby Staff surgeon, Orthopedics, Orthopedics, and trauma department, Damanhur teaching hospital, Egypt
Alaa-eldin Mohey-eldin Soliman Professor of orthopedic surgery, Cairo University, Egypt
Hisham Mesbah Soliman Professor of orthopedic surgery, Cairo University, Egypt
Hazem A. Farouk
hfarouk@kasralainy.edu.eg
Associate Professor Orthopaedics & Trauma Department Sports Injuries & Arthroscopies Unit, Faculty of Medicine, Cairo University, Egypt

Keywords:

sub-acromial, platelet-rich plasma, supraspinatus tendinopathy, hyaluronic acid

Abstract

Objective: To compare the effect of local injection of platelet-rich plasma (PRP), Hyaluronic acid, or Placebo for management of Supraspinatus tendinopathy (SST) and their outcomes regarding functional scores and MRI changes. Design: Double-blind randomized controlled trial with 1-year follow-up. Methods: 60 Participants recruited from an outpatient Orthopaedic clinic had clinically and radiologically (MRI)–demonstrated SST refractory to physical therapy. They received a local injection of either 3.5 mL of PRP, Hyaluronic acid (2 doses a week apart), or 3.0 mL of 1% xylocaine at the lesion and surrounding tendon (20 participants each). Patients aged from 21 to 65 years with symptoms of SST for 3 months or more do not improve after at least 4 weeks of formal physical therapy with magnetic resonance imaging (MRI) changes indicating tendinopathy without RC tears or labral lesions, or significant glenohumeral arthrosis. Exclusion criteria included joint instability, patients on anticoagulation therapy, history of shoulder surgery, full-thickness Supraspinatus tear, Type 3 or 4 acromions, and corticosteroid injection within 3 months. Primary outcome: 0-10 visual analog scale (VAS) and functional shoulder tests assessing rotator cuff strength and endurance (at baseline and 8 and 12 weeks).

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