Validity of neutrophil lymphocyte count ratio in neonatal sepsis

https://doi.org/10.29332/ijhs.v5n2.1148

Authors

  • Heriyanto Lim Department of Child Health, Medical School of Udayana Univesity, Denpasar, Indonesia
  • Made Sukmawati Department of Child Health, Medical School of Udayana Univesity, Denpasar, Indonesia
  • Wayan Dharma Artana Department of Child Health, Medical School of Udayana Univesity, Denpasar, Indonesia
  • Made Kardana Department of Child Health, Medical School of Udayana Univesity, Denpasar, Indonesia
  • Putu Junara Putra Department of Child Health, Medical School of Udayana Univesity, Denpasar, Indonesia

Keywords:

neonatal sepsis, neutrophil lymphocyte count ratio, procalcitonin

Abstract

Sepsis is a major problem in neonatal care that has not been resolved. This condition is becoming one of major cause of morbidity and mortality in neonates especially in developing countries. Neutrophil lymphocytes count ratio (NLCR) is a new marker of infection that is easy, rapid method and less expensive that can be done in limited health care facilities. A retrospective study with cross sectional design was conducted on 84 neonates with sepsis. The data was collected from medical records from April 2018 to September 2018 in Perinatology Division Sanglah hospital. ROC curve is was done to determine the value cut-off point, sensitivity and specificity of NLCR. With cut-off point of 2.31 NLCR has prevalence, sensitivity, specificity, positive predictive value (PPV) and negative pedictive value (NPV) of 26.1%, 81.8%, 66.1%, 46.1% and 91.1%. NLCR is potential to be used in the diagnosis of neonatal sepsis.

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References

Alkan Ozdemir, S., Arun Ozer, E., Ilhan, O., & Sutcuoglu, S. (2018). Can neutrophil to lymphocyte ratio predict late?onset sepsis in preterm infants?. Journal of clinical laboratory analysis, 32(4), e22338. https://doi.org/10.1002/jcla.22338

Can, E., Hamilcikan, ?., & Can, C. (2018). The value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for detecting early-onset neonatal sepsis. Journal of pediatric hematology/oncology, 40(4), e229-e232. https://doi.org/10.1097/MPH.0000000000001059

Darnifayanti, D., Tjipta, G. D., Rusdidjas, R., & Lubis, B. M. (2015). Immature-to-total neutrophil ratio as an early diagnostic tool of bacterial neonatal sepsis. Paediatrica Indonesiana, 55(3), 153-7. https://doi.org/10.14238/pi55.3.2015.153-7

Department of Health (2007). Basic Health Research Report (Riskesdas). Jakarta: Health Research and Development Board of the Ministry of Health of the Republic of Indonesia.

Fleischmann-Struzek, C., Goldfarb, D. M., Schlattmann, P., Schlapbach, L. J., Reinhart, K., & Kissoon, N. (2018). The global burden of paediatric and neonatal sepsis: a systematic review. The Lancet Respiratory Medicine, 6(3), 223-230. https://doi.org/10.1016/S2213-2600(18)30063-8

Gurol, G., Ciftci, I. H., Terzi, H. A., Atasoy, A. R., Ozbek, A., & Koroglu, M. (2015). Are there standardized cutoff values for neutrophil-lymphocyte ratios in bacteremia or sepsis?. Journal of microbiology and biotechnology, 25(4), 521-525. https://doi.org/10.4014/jmb.1408.08060

Holub, M., Beran, O., Kasp?íková, N., & Chalupa, P. (2012). Neutrophil to lymphocyte count ratio as a biomarker of bacterial infections. Open Medicine, 7(2), 258-261. https://doi.org/10.2478/s11536-012-0002-3

Kardana, I. M. (2011). Incidence and factors associated with mortality of neonatal sepsis. Paediatrica Indonesiana, 51(3), 144-8. https://doi.org/10.14238/pi51.3.2011.144-8

Kartal, O., & Kartal, A. T. (2017). Value of neutrophil to lymphocyte and platelet to lymphocyte ratios in pneumonia. Bratislavske lekarske listy, 118(9), 513-516.

Khoshdel A, Mahmoudzadeh M, Kheiri S, Imani R, Sahahabi G, Saedi E, Taheri E, Motamed R. (2008). Sensitivity and specificity of procalcitonin in diagnosis of neonatal sepsis. Iranian Journal of Pathology, 3(4):20-37.

Liu, X., Shen, Y., Wang, H., Ge, Q., Fei, A., & Pan, S. (2016). Prognostic significance of neutrophil-to-lymphocyte ratio in patients with sepsis: a prospective observational study. Mediators of inflammation, 2016. https://doi.org/10.1155/2016/8191254

Loni, R., Sengupta, A., Jaganathan, G., & Singh, P. K. (2016). The evaluation of C-reactive protein as a screening tool for neonatal sepsis. International Journal of Contemporary Pediatrics, 3(4), 1329-1333.

Madiyono B, Marzuqi SM, Sastroasmoro S, Budiman I, Purwanto SH (2011). Estimated sample size. In: Sastroasmoro S, Ismael S, editors. Dasar-dasar metodologi penelitian klinis. 4th ed. Jakarta: Sagung Seto; 359.

Melvan, J. N., Bagby, G. J., Welsh, D. A., Nelson, S., & Zhang, P. (2010). Neonatal sepsis and neutrophil insufficiencies. International reviews of immunology, 29(3), 315-348. https://doi.org/10.3109/08830181003792803

Memar, M. Y., Varshochi, M., Shokouhi, B., Asgharzadeh, M., & Kafil, H. S. (2017). Procalcitonin: the marker of pediatric bacterial infection. Biomedicine & Pharmacotherapy, 96, 936-943. https://doi.org/10.1016/j.biopha.2017.11.149

Omran, A., Maaroof, A., Saleh, M. H., & Abdelwahab, A. (2018). Salivary C?reactive protein, mean platelet volume and neutrophil lymphocyte ratio as diagnostic markers for neonatal sepsis. Jornal de Pediatria (Versão em Português), 94(1), 82-87. https://doi.org/10.1016/j.jpedp.2017.07.004

Oyong, N., Anggraini, D., & Karina, K. (2016). Pola resistensi bakteri penyebab sepsis neonatorum di instalasi perawatan neonatus RSUD arifin achmad riau. Sari Pediatri, 17(6), 435-40.

Sankar, M. J., Agarwal, R., Deorari, A. K., & Paul, V. K. (2008). Sepsis in the newborn. The Indian Journal of Pediatrics, 75(3), 261-266. https://doi.org/10.1007/s12098-008-0056-z

Sarraf, K. M., Belcher, E., Raevsky, E., Nicholson, A. G., Goldstraw, P., & Lim, E. (2009). Neutrophil/lymphocyte ratio and its association with survival after complete resection in non–small cell lung cancer. The Journal of thoracic and cardiovascular surgery, 137(2), 425-428. https://doi.org/10.1016/j.jtcvs.2008.05.046

Shah, B. A., & Padbury, J. F. (2014). Neonatal sepsis: an old problem with new insights. Virulence, 5(1), 170-178. https://doi.org/10.4161/viru.26906

Shane, A. L., Sánchez, P. J., & Stoll, B. J. (2017). Neonatal sepsis. The lancet, 390(10104), 1770-1780. https://doi.org/10.1016/S0140-6736(17)31002-4

Shen, C. J., Miao, T., Wang, Z. F., Li, Z. F., Huang, L. Q., Chen, T. T., & Yan, W. H. (2019). Predictive value of post-operative neutrophil/lymphocyte count ratio for surgical site infection in patients following posterior lumbar spinal surgery. International immunopharmacology, 74, 105705. https://doi.org/10.1016/j.intimp.2019.105705

World Health Organisation. (2006).: Neonatal and perinatal mortality: country, regional and global estimates. WHO. cebu: sun.

Wu, J. H., Chen, C. Y., Tsao, P. N., Hsieh, W. S., & Chou, H. C. (2009). Neonatal sepsis: a 6-year analysis in a neonatal care unit in Taiwan. Pediatrics & Neonatology, 50(3), 88-95. https://doi.org/10.1016/S1875-9572(09)60042-5

Zadora, P., Dabrowski, W., Czarko, K., Smolen, A., Kotlinska-Hasiec, E., Wiorkowski, K., ... & Trojanowski, T. (2015). Preoperative neutrophil–lymphocyte count ratio helps predict the grade of glial tumor–a pilot study. Neurologia i neurochirurgia polska, 49(1), 41-44. https://doi.org/10.1016/j.pjnns.2014.12.006

Zhao, Z., Liu, J., Wang, J., Xie, T., Zhang, Q., Feng, S., ... & Zhong, B. (2017). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are associated with chronic hepatitis B virus (HBV) infection. International immunopharmacology, 51, 1-8. https://doi.org/10.1016/j.intimp.2017.07.007

Published

2021-05-10

How to Cite

Lim, H., Sukmawati, M., Artana, W. D., Kardana, M., & Putra, P. J. (2021). Validity of neutrophil lymphocyte count ratio in neonatal sepsis. International Journal of Health Sciences, 5(2), 53-61. https://doi.org/10.29332/ijhs.v5n2.1148

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