Clinical and histological assessment of efficacy of theracal LC and biodentine as direct pulp capping agents- An in-vivo study
Keywords:
Dental pulp capping, Pulp capping, Tricalcium silicate cementAbstract
Context: Since there is paucity of clinical studies, concern arises regarding the safety of direct application of resin-containing material like TheraCal LC on the pulp tissue. Aim: To assess clinically and histologically the efficacy of TheraCal LC and Biodentine as Direct Pulp Capping agents Materials and Method: Sixty caries-free maxillary first premolar teeth which were scheduled for orthodontic extraction were selected for the study which were divided equally into Group 1 (Theracal LC) and Group 2 (Biodentine). Thermal and electric pulp testing was performed on the teeth to assess pulp vitality followed by tooth preparation to expose pulp horns under local anaesthesia. After achieving hemostasis, the direct pulp capping agent was placed and composite restoration was done. All the teeth were evaluated and compared in terms of clinical and histological findings after 6 weeks. Statistical analysis used was Kruskal-Wallis test. Results: Teeth with Theracal LC showed no sensitivity to heat, cold, or percussion, whereas sensitivity to heat, cold, or percussion was noted with Biodentine.
Downloads
References
Horsted-Bindslev P, Lovshall H. Treatment outcome of vital pulp treatment. Endodontic Topics 2002;2:24-34.
Laurent P, Camps J, About I. Biodentine TM induces TGF-b1 release from human pulp cells and early dental pulp mineralization. Int Endod J 2012;45:439–48.
Gandolfi MG, Siboni F, Prati C. Chemical-physical properties of Theracal, a novel; light cure MTA- like material for pulp capping. Int J Endod 2012;45:571-579.
Nowicka A, Lipski M, Parafiniuk M, Sporniak-Tutak K, Lichota D, Kosierkiewicz A et al. Response of human dental pulp capped with biodentine and mineral trioxide aggregate. J Endod. 2013;39(6):743-7. doi: 10.1016/j.joen.2013.01.005. PMID: 23683272.
Asgary S, Eghbal MJ, Parirokh M. A comparative study of histologic response to different pulp capping materials and a novel endodontic cement. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:609-14.
Zarrabi MH, Javidi M, Jafarian AH, Joushan B. Histologic assessment of human pulp response to capping with mineral trioxide aggregate and a novel endodontic cement. J Endod 2010;36:1778-81.
Al-Hezaimi K, Salameh Z, Al-Fouzan K, Al Rejaie M, Tay FR. Histomorphometric and micro-computed tomography analysis of pulpal response to three different pulp capping materials. J Endod. 2011;37(4):507-12. doi: 10.1016/j.joen.2010.11.001. PMID: 21419299.
Hebling J, Lessa FC, Nogueira I, Carvalho RM, Costa CA. Cytotoxicity of resin-based light-cured liners. Am J Dent. 2009 Jun;22(3):137-42. PMID: 19650592.
Furey A, Hjelmhaug J, Lobner D. Toxicity of Flow Line, Durafill VS, and Dycal to dental pulp cells: effects of growth factors. J Endod. 2010;36(7):1149-53. doi: 10.1016/j.joen.2010.03.013. Epub 2010 Apr 9. PMID: 20630288; PMCID: PMC2907173.
Gandolfi MG, Siboni F, Taddei P et al. Apatite-Forming Ability of TheraCal Pulp-Capping Material. Presented at: Int Assoc Dent Res 2011 Abstract #2520.
Huria A, Gundappa M, Rani A, Agarwal A. Clinical outcome of Direct pulp capping with MTA, Biodentine and Calcium Hydroxide: A Systematic Review and Meta- Analysis. TMU J Dent. 2018;5:3-7.
Griffin JD. Utilizing Bioactive Liners: Stimulating Post-Traumatic Dentin Formation. Dent today 2012;31(10):132-6. PMID: 23156640.
Qureshi A, Soujanya E, Nandakumar, Pratapkumar, Sambashivarao. Recent Advances in Pulp Capping Materials: An Overview. J Clin Diagn Res 2014;8(1):316-21.
Kunert M, Lukomska-Szymanska M. Bio-Inductive Materials in Direct and Indirect Pulp Capping—A Review Article. Materials 2020;13:1204. doi:10.3390/ma13051204
Gandolfi MG, Francesco S, Tatiana B, Maurizio B, Francesco R, Carlo Pet al. Calcium silicate and calcium hydroxide materials for pulp capping: biointeractivity, porosity, solubility and bioactivity of current formulations. J Appl Biomater Funct Mater 2015;13(1):43-60.
Comisi CC. Bioactive Materials Support Proactive Dental Care. Cosmetic Dent 2012;1:7-13.
Brown DJ. Achieve Predictable And Esthetic Posterior Restorations With A Highly Adaptive Calcium Silicate. Inside Dentistry 2012;8:4.
Cannon M, Gerodias N, Viera A, Percinoto C, Jurado R. Primate pulpal healing after exposure and TheraCal application. J Clin Pediatr Dent 2014;38:333‑7.
Makkar S, Kaur H, Aggarwal A, Vashisht R. A confocal laser scanning microscopic study evaluating the sealing ability of mineral trioxide aggregate, biodentine and a new pulp capping agent‑TheraCal. Dent J Adv Stud 2015;3:20‑5.
Iwamoto C, Adachi E, Pameijer C, Barnes D, Romberg E, Jefferies S. Clinical and histological evaluation of white ProRoot MTA in direct pulp capping. American Journal of Dentistry. 2006;19:85–90.
Aeinehchi M, Eslami B, Ghanbariha M, Saffar A. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: A preliminary report. International Endodontics Journal. 2002;36:225–31.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938
Camilleri J, Laurent P, About I. Hydration of Biodentine, Theracal LC, and a prototype tricalcium silicate-based dentin replacement material after pulp capping in entire tooth cultures. J Endod. 2014;40(11):1846-54. doi: 10.1016/j.joen.2014.06.018. Epub 2014 Aug 22. PMID: 25154317.
Camilleri J. Hydration characteristics of Biodentine and Theracal used as pulp capping materials. Dent Mater 2014;30(7):709-715.
Menon NP, Varma BR, Janardhanan S, Kumaran P, Xavier AM, Govinda BS. Clinical and radiographic comparison of indirect pulp treatment using light‑cured calcium silicate and mineral trioxide aggregate in primary molars: A randomized clinical trial. Contemp Clin Dent 2016;7:475-80.
Savas S, Botsali M, Kucukyilmaz E, Sari T. Evaluation of temperature changes in the pulp chamber during polymerization of light-cured pulp-capping materials by using a VALO LED light curing unit at different curing distances. Dent Mater J 2014;33(6):764-9.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








