Prevalence and risk factors of latent tuberculosis infection in adolescent in Islamic boarding schools

Rizaldo Bagoes Dinatha; Retno Asih Setyoningrum

doi:10.53730/ijhs.v6nS9.12597

Authors

Rizaldo Bagoes Dinatha Department of Child Health, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Retno Asih Setyoningrum
retnosoedijo@gmail.com
Department of Child Health, Faculty of Medicine, Airlangga University, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia

Keywords:

Tuberculosis, latent tuberculosis, adolescents, Islamic boarding schools, risk factors

Abstract

Latent tuberculosis infection (LTI) is an obstacle in eradicating pulmonary tuberculosis. 5-10% people with LTI will develop into active tuberculosis (TB) in the first 5 years after the first TB infection. Islamic boarding schools are a highly potential area in increasing LTI incidents in adolescents. Existing studies are mostly focused on reporting LTI in the general population. To determine the prevalence and risk factors of LTI in adolescents in islamic boarding schools in Bangkalan Madura. A cross sectional study was conducted at the Islamic Boarding School Bangkalan Madura in January 2022 using a random sampling technique. The IGRA examination using the QIAreach QuantiFERON TB tool. The risk factors analyzed include age, gender, nutritional status, TB contact history, duration of stay in Islamic boarding schools and level of knowledge. The data obtained were further analyzed using chi-square and logistic regression test. A total of 100 subjects were examined by IGRA resulting in 30 positive subjects consisting of 30.3% male and 29.9% female. TB contact history (OR 5.167; 95% CI = 1.831-14.567; p=0.002) and level of knowledge about TB (OR 0.019; 95% CI = 0.005-0.069; p<0.05) are significantly related to the incidence of LTI in adolescents in islamic boarding schools.

Downloads

Download data is not yet available.

References

Daulay RS, Majeda A, Nataprawira HM. Unrecognized and delayed to diagnose of adolescence tuberculosis case in a boarding school in West Java, Indonesia. Int J Mycobacteriol. 2018;7 (4):387–9. DOI: http://dx.doi.org/10.4103/ijmy.ijmy_149_18

Dorjee K, Topgyal S, Dorjee C, Tsundue T, Namdol T, Tsewang T, et al. High prevalence of active and latent tuberculosis in children and adolescents in Tibetan schools in India: The zero TB kids initiative in Tibetan refugee children. Clinical Infectious Diseases. 2019;69 (5):760–8. DOI: http://dx.doi.org/10.1093/cid/ciy987

Flynn, J. L dan Chan, J. Tuberculosis: latency and reactivation. Infect Immun, 2001;69 (7), 4195-201. DOI: https://doi.org/10.1128/IAI.69.7.4195-4201.2001

Frieden TR, Lerner BH, Rutherford BR. Lessons from the 1800s: tuberculosis control in the new millennium. Lancet. 2000;355 (9209):1088–92. DOI: https://doi.org/10.1016/S0140-6736(00)02048-1

Hatzenbuehler LA, Starke JR, Graviss EA, Smith EO, Cruz AT. School-based study to identify and treat adolescent students at risk for tuberculosis infection. Pediatr Infect Dis J. 2016;35 (7):733–8. DOI: http://dx.doi.org/10.1097/INF.0000000000001151

Hossain S, Zaman K, Quaiyum A, Banu S, Husain A, Islam A, et al. Factors associated with poor knowledge among adults on tuberculosis in Bangladesh: results from a nationwide survey. J Health Popul Nutr. 2015;34 (1):2. DOI http://dx.doi.org/10.1186/s41043-015-0002-4

Houben, R. and Dodd, P. The Global Burden of Latent Tuberculosis Infection: A Re-estimation Using Mathematical Modelling. PLoS Med. 2016;13 (10):e1002152. DOI: https://doi.org/10.1371/jour- nal.pmed.1002152.

Jaganath, D and Mupere, E. Childhood tuberculosis and malnutrition. J Infect Dis, 2012:206 (12):1809-15. DOI: https://doi.org/10.1093/infdis/jis608

Jubulis J, Kinikar A, Ithape M, Khandave M, Dixit S, Hotalkar S, et al. Modifiable risk factors associated with tuberculosis disease in children in Pune, India. Int J Tuberc Lung Dis. 2014;18 (2):198–204. DOI: http://dx.doi.org/10.5588/ijtld.13.0314

Kementerian Kesehatan Republik Indonesia. Petunjuk Teknis Manajemen dan Tatalaksana TB Anak. Jakarta, Kementerian Kesehatan Republik Indonesia, 2016; pp. 9-34, 61-70.

Landry J, Menzies D. Preventive chemotherapy. Where has it got us? Where to go next? Int J Tuberc Lung Dis. 2008;12 (12):1352–64. Available from: https://pubmed.ncbi.nlm.nih.gov/19017442/

Lin H-H, Wu C-Y, Wang C-H, Fu H, Lönnroth K, Chang Y-C, et al. Association of obesity, diabetes, and risk of tuberculosis: Two population-based cohorts. Clin Infect Dis . 2018;66 (5):699–705. DOI: http://dx.doi.org/10.1093/cid/cix852

Ma M-J, Yang Y, Wang H-B, Zhu Y-F, Fang L-Q, An X-P, et al. Transmissibility of tuberculosis among school contacts: an outbreak investigation in a boarding middle school, China. Center for Inference and Dynamics of Infectious Diseases, Infection, Genetic and Evolution. 2015;32:148–55. DOI: http://dx.doi.org/10.1016/j.meegid.2015.03.001

Merta, I. N., & Suderana, I. W. (2020). COVID-19 pandemic handling community social and cultural sector stimulus efforts. International Journal of Social Sciences and Humanities, 4(3), 1–12. https://doi.org/10.29332/ijssh.v4n3.434

Nhamoyebonde S, Leslie A. Biological differences between the sexes and susceptibility to tuberculosis. J Infect Dis. 2014;209 Suppl 3(suppl 3):S100-6. DOI: https://doi.org/10.1093/infdis/jiu147

Parker L. The Experience of Adolescent Students in Modernist Islamic Boarding Schools in West Sumatra, Indonesia. In Vicziany AM, Institute MA, University M, Cribb R, University TAN, editors, Proceedings of the 17th Biennial Conference of the ASAA, Melbourne, Australia. Melbourne ed. Vol. 17. http://arts.monash.edu.au/mai/asaa/: The Asian Studies Association of Australia (ASAA). 2008. p. 18 pp

Setiawan, G., Juniarti, N. and Yani, D. Hubungan Gaya Hidup Dengan Kejadian TB Paru Pada Remaja: Kajian Literatur Sistematis. Jurnal Keperawatan Komprehensif . 2019;5 (1): 10-7. DOI: https://doi.org/10.33755/jkk.v5i1.118

Sharma, K. (2016). Vocational interest regarding career awareness among adolescent boys and girls of Rohtak city: Haryana (India). International Research Journal of Management, IT and Social Sciences, 3(3), 16-21.

Sloot R, Schim van der Loeff MF, Kouw PM, Borgdorff MW. Risk of tuberculosis after recent exposure. A 10-year follow-up study of contacts in Amsterdam. Am J Respir Crit Care Med . 2014;190 (9):1044–52. DOI: http://dx.doi.org/10.1164/rccm.201406-1159OC

Stein-Zamir C, Volovik I, Rishpon S, Atamna A, Lavy A, Weiler-Ravell D. Tuberculosis outbreak among students in a boarding school. Eur Respir J. 2006;28 (5):986–91. DOI: http://dx.doi.org/10.1183/09031936.06.00002506

Stival A, Chiappini E, Montagnani C, Orlandini E, Buzzoni C, Galli L, et al. Sexual dimorphism in tuberculosis incidence: children cases compared to adult cases in Tuscany from 1997 to 2011. PLoS One. 2014;9 (9):e105277. DOI: http://dx.doi.org/10.1371/journal.pone.0105277

Surahman A, Nurlaela Hadi E, Anggun Dimar Setio K. Pulmonary tuberculosis suspects and their determinants among boarding students in Islamic boarding schools in the garut district. KnE life sci. 2018;4 (4):93. DOI: http://dx.doi.org/10.18502/kls.v4i4.2267

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Trauer JM, Moyo N, Tay E-L, Dale K, Ragonnet R, McBryde ES, et al. Risk of active tuberculosis in the five years following infection? Chest. 2016;149 (2):516–25. DOI: http://dx.doi.org/10.1016/j.chest.2015.11.017

World Health Organization. Global Tuberculosis Report 2020 [Internet]. 2020 Oct. Available from: https://www.who.int/publications/i/item/9789240013131