The glycemic control among type 1 diabetes children pre and during COVID-19 pandemic: A systematic review and meta-analysis

Wika Y. Deakandi; Farahdina  Farahdina; Qurrota A. N. Putri; Tyas M. Nuzula; Katherine Fedora; Qorri Aina; Nur Rochmah; Muhammad Faizi

doi:10.53730/ijhs.v6nS9.12893

Authors

Wika Y. Deakandi Faculty of Medicine, Universitas Islam Malang, Malang, Indonesia
Farahdina Farahdina Faculty of Medicine, Department of child health, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, East Java, Indonesia
Qurrota A. N. Putri Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Tyas M. Nuzula Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Katherine Fedora Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Qorri Aina Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Nur Rochmah
nur-r@fk.unair.ac.id
Faculty of Medicine, Department of child health, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, East Java, Indonesia
Muhammad Faizi Faculty of Medicine, Department of child health, Dr. Soetomo General Hospital, Universitas Airlangga, Surabaya, East Java, Indonesia

Keywords:

HbA1c, T1DM, Mean glucose, COVID-19

Abstract

The impact of the COVID-19 pandemic on glycemic control in Type 1 Diabetes Mellitus (T1DM) patients is still evolving. This study aims to assess the negative effect of the COVID-19 pandemic on mean glucose and glycated hemoglobin (HbA1c) in patients with T1DM. This meta-analysis study using the PRISMA framework method with the search strategy according to the population, intervention, control, and outcome (PICO) model. Relevant articles were searched in 4 databases. The results identified the HbA1c and mean glucose. The COVID-19 pandemic caused an increase in the HbA1c levels (%) compared to the pre-COVID group with a mean difference of -1.06 (95% CI: -1.44, -0.69; p<0.00001). Meanwhile, the mean glucose (mg/dL) decreased during-COVID-19 pandemic with a mean difference of -2.32 (95% CI: -4.40, -0.23; p=0.03). Ten studies with a total of 1615 subjects contributed for HbA1c analysis (during-COVID-19, n = 615; pre-COVID, n = 1000). A total of 1164 patients from six studies with a mean glucose analysis were included (during-COVID-19, n = 418; pre-COVID, n = 746). This study found that the COVID-19 pandemic significantly increased the levels of HbA1c and decreased mean glucose in patients with T1DM, but further studies need to be evaluated.

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