Association of serum high-sensitivity creactive protein level with metabolic syndrome

Rathore Rajkumari; Jain Abhijeet; Marandi Gujaram; P. G Dhone; Rai Neeta

doi:10.53730/ijhs.v6nS1.7223

Authors

Rathore Rajkumari Associate Professor, Department of Biochemistry Bhima Bhoi medical college Balangir
Jain Abhijeet Assistant Professor Department of Ophthalmology RSDKS GMC, Ambikapur
Marandi Gujaram Assistant professor, Department of Pharmacology Bhima Bhoi Medical College and Hospital, Balangir
Dhone P. G Professor & Head, Department of Pharmacology, RSDKS GMC, Ambikapur
Rai Neeta School of Pharmacy, Vishwakarma University, Pune. Maharashtra, India

Keywords:

Metabolic syndrome, High sensitivity C-reactive protein, Obesity, Cardiovascular disease, Diabetes mellitus

Abstract

Background – Metabolic syndrome is considered as pro inflammatory state, measurement of hsCRP might help in the prediction of onset of CVD. We analyzed the association of serum hsCRP level with metabolic syndrome. Methods- the study included the 140 diagnosed case of metabolic syndrome (Men= 81, Women= 5). We measured the fasting glucose, fasting lipid panel & serum hsCRP level. Serum hsCRP level was compared with the components of metabolic syndrome. Results- High level of hsCRP was found in both men (67.9 %) & women (66.1%) with metabolic syndrome. The most common components of metabolic syndrome were abdominal obesity in women, while high TG, hypertension & low HDL-C was common in men. hsCRP level was found to be significantly increased in metabolic syndrome subjects with diabetes mellitus and obesity. In addition, hsCRP was significantly increased with increasing the number of components of metabolic syndrome. Conclusion- Measurement of hsCRP level indicates the inflammation associated with obesity & diabetes mellitus that might be explained the increasing the risk for development of cardiovascular disease.

Downloads

Download data is not yet available.

References

Olijhoek JK, Martens FM, Banga JD, and Visseren FL. Ned Tijdschr Geneeskd 2005;149(16):859-65.

Pepys, MB, Hirschfield, GM. C-reactive protein: a critical update. J Clin Invest 2003; 111: 1805-12.

Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004; 109(3):433–438.

Ridker PM, Wilson PW, Grundy SM. Should C-reactive protein be added to metabolic syndrome and to assessment of global cardiovascular risk? Circulation. 2004; 109(23): 2818–2825.

Festa A, D’Agostino R Jr, Howard G, Mykka¨nen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation. 2000; 102(1):42–47.

Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation. 2005; 111(11): 1448–1454.

Expert panel on Detection, Evaluation and treatment of high blood cholesterol in adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP III). Journal of American Medical Association (JAMA) 2001;285(19):2486-97.

Trinder, P. Ann.Clin.Biochem 6:24 (1964).

Berthelot, M.P.E., Report Clin. Appl. 2884 (1859).

Bowers L.D., Clin. Chem., 26, p 551-556 (1980).

Trivedi R.C., et. al., Clin. Chem., 24(11), 1908-1911 (1978).

Danesh J et al. C reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004; 350:1387-1397.

Sudha Vidyasagar, UK Abdul Razak, CK Prashanth, D Muralidar Varma, KL Bairy. High sensitive C-reactive protein in metabolic syndrome. JIACM 2013; 14(3-4):230-4.

Ludescher B, Najib A, Baar S, et al. Gender specific correlations of adrenal gland size and body fat distribution: a whole body MRI study. Horm Metab Res. 2007; 39(7):515–518.

Okosun IS, Chandra KM, Boev A, et al. Abdominal adiposity in US adults: prevalence and trends, 1960–2000. Prev Med. 2004; 39(1):197–206.

Fatma G. Huffman, Gianna Perez Gomez, Gustavo G. Zarini. Metabolic syndrome and high sensitivity C-reactive protein in Cubans. Ethnicity & Disease Spring 2009; 9:115-120.

Van Guilder GP, Hoetzer GL, Greiner JJ, Stauffer BI, DeSouza CA . Influence of metabolic syndrome on biomarkers of oxidative stress and inflammation in obese adults. Obesity 2006; 14:2127-2131.

Pitsovas C. Diet, exercise and CRP levels in people with abdominal obesity: the ATTICA epidemiological study. Angiology 2007; 58: 225- 33.

Nakamura H, Ito H, Egami Y, et al. Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrome. Diabetes Res Clin Pract. 2008;79(2):330–336.

Blake GJ, Rifai N, Buring JE et al. Blood pressure, CRP and risk of future cardiovascular events. Circulation 2003; 108: 2993-9.

Picardi A, Valorani MG, Vespasiani Gentilucci U et al. Raised CRP levels in patients with recent onset type 1 diabetes. Diabetes Metab Res Rev 2007; 23: 211-4.

Lee WY, Park JS, Noh SY, et al. C-reactive protein concentrations are related to insulin resistance and metabolic syndrome as defined by the ATP III report. Int J Cardiol. 2004; 97(1):101–106.

Choi EY, Park EH, Cheong YS, Rheem I, Park SG, Yoo S. Association of C-reactive protein with the metabolic risk factors among young and middle-aged Koreans. Metabolism. 2006; 55(3):415–421.

Bo S, Gentile L, Ciccone G et al. The metabolic syndrome and high C-reactive protein: prevalence and differences by sex in a southern European population-based cohort. Diabetes Metab Res Rev 2005; 21: 515-24.