High antioxidant level in cajanus sajan reduces blood glucose level and improves blood lipid profile of rats as diabetes mellitus models
Keywords:blood glucose, cholesterol, lipid profile, pigeon bean tempe, triglycerides
Hyperglycemia in DM was able to increase glucose auto-oxidation, protein glycation, and polyol pathway activation. As a result, it can accelerate the formation of reactive oxygen compounds acting as the main factor causing DM complication. Before we evaluated pigeon bean Tempe with formulations of 25%, 50%, and 75%, we tested the number and activity of its antioxidant. Then we substituted it on standard feed for 14 days to find the effects on glucose level and lipid profile. The effects were then compared to that before the intervention. The result showed that the total and activity of antioxidants in pigeon bean Tempe (Cajanus sajan) was 15% and 41.30% respectively. On the other side, pigeon bean Tempe with a formulation of 75% was more able to reduce blood glucose level, total cholesterol, triglycerides, and LDL-cholesterol by 44.08%, 34.38%,35.80%, and 43.22% respectively (p<0.05) if compared to pigeon bean Tempe with formulations of 25% and 50%. Meanwhile, pigeon bean Tempe with the formulation of 75% provided better effects for an increase of HDL level 56.20% (p<0.05). All test results on Tempe formulation used were compared to that before the intervention.
Attie, A. D., Krauss, R. M., Gray-Keller, M. P., Brownlie, A., Miyazaki, M., Kastelein, J. J., ... & Ntambi, J. M. (2002). Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. Journal of lipid research, 43(11), 1899-1907. https://doi.org/10.1194/jlr.M200189-JLR200
Candra Tama, S.A., Dewi, E. N., & Ibrahim, R. (2012). The Effect of Gracilaria verrucosa Extract Feeding to the Blood Glucose Content of White Rats (Rattus norvegicus). Saintek Perikanan: Indonesian Journal of Fisheries Science and Technology, 8(1), 1-6.
Chang JH., Min SK., Tae WK., Sang SL (2008). Effect of Soybean Suplementation on Blood Glucose, Plasma Lipid Levels, and Erythrocyte Antioxidant Enzyme Activity in Type 2 Diabetes Mellitus Patients. NRP 2(3): 152-157.
Coskun, O., Kanter, M., Korkmaz, A., & Oter, S. (2005). Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and ?-cell damage in rat pancreas. Pharmacological research, 51(2), 117-123. https://doi.org/10.1016/j.phrs.2004.06.002
Dykes, L., & Rooney, L. W. (2006). Sorghum and millet phenols and antioxidants. Journal of cereal science, 44(3), 236-251. https://doi.org/10.1016/j.jcs.2006.06.007
Elmarakby, A. A., Faulkner, J., Baban, B., Saleh, M. A., & Sullivan, J. C. (2012). Induction of hemeoxygenase-1 reduces glomerular injury and apoptosis in diabetic spontaneously hypertensive rats. American Journal of Physiology-Renal Physiology, 302(7), F791-F800.
Frans, M.J., & Allison, B.E. (2012). American Diabetes Association Guide for Nutrition Terapy for Diabetes second edition. American Diabetes Association, USA.
Haliza, W. (2008). Without Soybeans, You Can Still Eat Tempe. Center for Post-Harvest Agricultural Research and Development, Bogor.
Hirsch, I. B., & Brownlee, M. (2005). Should minimal blood glucose variability become the gold standard of glycemic control?. Journal of Diabetes and its Complications, 19(3), 178-181. https://doi.org/10.1016/j.jdiacomp.2004.10.001
Inawati, Syamsudin, & Winarno, H. (2006). Effect of Leaf Extract of Henna (Lawsonia inermis Linn) on Decreasing Levels of Glucose, Total Cholesterol, and Blood Triglycerides of Mice Induced by Aloksan.jki1 (2): 71-7.
Isdamayani, L., & Panunggal, B. (2015). Kandungan flavonoid, total fenol, dan antioksidan snack bar sorgum sebagai alternatif makanan selingan penderita diabetes mellitus tipe 2 (Doctoral dissertation, Diponegoro University).
Jawi, I. M., Suprapta, D. N., & Subawa, A. N. (2008). The Extract of Purple Sweet Potato Decrease Blood and Liver Mda of Mice after Intense Physical Activity. Jurnal Veteriner, 9(2).
Karunakaran, U., & Park, K. G. (2013). A systematic review of oxidative s
Kim, S. H., Hyun, S. H., & Choung, S. Y. (2006). Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of ethnopharmacology, 104(1-2), 119-123. https://doi.org/10.1016/j.jep.2005.08.059
Maritim, A. C., Sanders, A., & Watkins Iii, J. B. (2003). Diabetes, oxidative stress, and antioxidants: a review. Journal of biochemical and molecular toxicology, 17(1), 24-38.
Naudi, A., Jove, M., Ayala, V., Cassanye, A., Serrano, J., Gonzalo, H., ... & Pamplona, R. (2012). Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress. Experimental diabetes research, 2012.
Nurrahman, Astuti, N., Suparmo, Marsetyawan, H.N.E.S. (2012). The Role of Black Soybean Tempe in Increasing Antioxidant Enzymes and Resistance of Rat Limpocytes to Hydrogen Peroxide In Vivo. Seminar on Research Results, LPPM Unimus.
Nuttall, S. L., Dunne, F., Kendall, M. J., & Martin, U. (1999). Age-independent oxidative stress in elderly patients with non-insulin-dependent diabetes mellitus. Qjm, 92(1), 33-38.
Packer, L., Peter R., Hans J,T., George L,K.,,Angelo, (2000). Antioxidant in Diabetic Managemet. Marcel Dekker, Inc, New York.
Partama, I. B. G., Yadnya, T. G. B., Trisnadewi, A. A. A. S., & Sukada, I. K. (2018). Fermented rice husk utilization of effective microorganisms-4 supplemented with Piper betle L. performance, meat quality, antioxidant capacity, and meat cholesterol levels of Bali duck. International Journal of Life Sciences, 2(3), 98-110.
Selawa, W., Runtuwene, M. R., & Citraningtyas, G. (2013). Kandungan flavonoid dan kapasitas antioksidan total ekstrak etanol daun binahong [Anredera cordifolia (Ten.) Steenis.]. Pharmacon, 2(1).
Setiawan, B., Suhartono, E., & Mashuri, M. (2005). Kajian Stress Oksidatif Pada Bayi Prematur. Mutiara Medika: Jurnal Kedokteran dan Kesehatan, 5(1), 27-35.
Tensiska. (2009). Food fiber. Scientific Libraries, Univ. Padjadjaran.
Tjokroprawiro, A. (2003). Diabetes mellitus: kelasifikasi, diagnosis dan terapi. Gramedia Pustaka Utama.
Warabi, Y., Kusdiana, D., & Saka, S. (2004). Reactivity of triglycerides and fatty acids of rapeseed oil in supercritical alcohols. Bioresource technology, 91(3), 283-287. https://doi.org/10.1016/S0960-8524(03)00202-5
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care, 27(5), 1047-1053.
Xu, B. J., & Chang, S. K. C. (2007). A comparative study on phenolic profiles and antioxidant activities of legumes as affected by extraction solvents. Journal of food science, 72(2), S159-S166.
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