Cost effective preservatives free ophthalmic formulation

Srishti Namdeo; Sonam Chhipane

doi:10.53730/ijhs.v6nS4.10256

Cost effective preservatives free ophthalmic formulation

https://doi.org/10.53730/ijhs.v6nS4.10256

Authors

Srishti Namdeo
srishti.namdeo@kalingauniversity.ac.in
Faculty of Pharmacy, Kalinga University, Naya Raipur
Sonam Chhipane Faculty of Pharmacy, Kalinga University, Naya Raipur

Keywords:

ophthalmic, ocular surface disease (OSD), cost effective preservatives

Abstract

The present invention is directed to a method for producing an ophthalmic pharmaceutical formulation containing a carbonic anhydrase inhibitor, hydroxyl ethyl cellulose (HEC), and a beta-adrenergic antagonist for the treatment of ocular hypertension and glaucoma that is free of benzalkonium chloride and other preservatives. The current production technique is a simpler, more cost-effective method of preparing pharmaceutical ophthalmic formulations in a single tank without the usage of extra sterile-filtered tanks. For individuals with newly diagnosed glaucoma, optical therapy is usually the initial line of treatment. Preservatives are essential in all multi-dose ophthalmic drugs to maintain an antibacterial environment in the container, thus eye care professionals must be aware of the effects of preservatives on the ocular surface.

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References

De Saint Jean M., et al. “Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells”. Investigative Ophthalmology and Visual Science 40.3 (1999): 619-630.

Fattakhov, N., Normatova, S., Madaminov, S., Tilyakhodzhaeva, G., & Abdulkhakimov, A. (2021). Hirudotherapy as an effective method for treatment of migraine - a disease of unknown etiology. International Journal of Health & Medical Sciences, 4(2), 232-237. https://doi.org/10.31295/ijhms.v4n2.1714

Freeman PD and Kahook MY. “Preservatives in topical ophthalmic medications: historical and clinical perspectives”. Expert Review of Ophthalmology 4.1 (2009): 59-64.

Gayton JL. “Etiology, prevalence, and treatment of dry eye disease”. Clinical Ophthalmology 3 (2009): 405-412.

Ghosh S., et al. “Prevalence of signs and symptoms of ocular surface disease in individuals treated and not treated with glaucoma medication”. Clinical and Experimental Ophthalmology 40.7 (2012): 675-681.

Janine AS. “The epidemiology of dry eye disease: report of the epidemiological subcommittee of the international dry eye workshop”. The Ocular Surface 5.2 (2007): 93-107.

Kaštelan S., et al. “How Ocular Surface Disease Impacts the Glaucoma Treatment Outcome”. BioMed Research International (2013).

Noecker RJ. “Ophthalmic Preservatives: Considerations for Long-term Use in Patients with Dry Eye or Glaucoma”. Review Ophthalmology 8.6 (2010): 1-8.

Noecker RJ., et al. “Corneal and conjunctival changes caused by commonly used glaucoma medications”. Cornea 23.5 (2004): 490-496.

Pisella PJP., et al. “Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication”. British Journal of Ophthalmology 86.4 (2002): 418-423

Skalicky SE., et al. “Ocular surface disease and quality of life in patients with glaucoma”. American Journal of Ophthalmology 153.1 (2012): 1-9.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864

Published

03-07-2022

How to Cite

Namdeo, S., & Chhipane, S. (2022). Cost effective preservatives free ophthalmic formulation. International Journal of Health Sciences, 6(S4), 7806–7809. https://doi.org/10.53730/ijhs.v6nS4.10256

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Issue

Vol. 6 No. S4 (2022)

Section

Peer Review Articles

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