Oxidative DNA damage level in relationship to zinc status in patients complaining hair fall, in Duhok city, Krg-Iraq: A case-control study

Marwa H. Rashad; Hishyar Azo Najeeb

doi:10.53730/ijhs.v6nS7.12908

Authors

Marwa H. Rashad Department of Medical Lab Technology, College of Health and Medical Technology of Shekhan, Duhok Polytechnic University, Duhok, Kurdistan Region, Iraq
Hishyar Azo Najeeb
hishyarakrey@uod.ac
Department of Medical Chemistry, Duhok medical research center, genoxicity reserach unit, College of Medicine, University of Duhok, Kurdistan Region, Iraq

Keywords:

hair loss, oxidative stress, DNA damage, serum zinc status

Abstract

Background: Oxidative stress is created form the imbalance between oxidants and antioxidants leading to increase aging and premature cell mortality. Endogenous DNA deterioration due to oxidative stress and DNA aging hasten hair fall. Zinc is an essential trace element that execute a marked role in hair loss, which acts as antioxidant against oxidative stress via involving in DNA repair mechanism. However, the impact of zinc deficiency in pathogenesis of hair loss is still demand further researches. Objective of study: to inspect the DNA oxidative damage relevant to zinc status in patients suffering from hair fall in Duhok city, Kurdistan Region-Iraq. Methods: a case-control study was carried out at department of Dermatology and skin disease, at Azadi teaching Hospital/Duhok on participants visiting the mentioned department from October 2021 till May 2022. 70 (58%) participants [22 males (31.4%) and 48 females (68.5%)] aged from 18-45 years and suffering from hair loss were enrolled in this work. 50 (41.6%) evidently healthy objects [ 31 males (62%) and 19 females (38%)] whose age and sex matched and showing no history of hair fall were also involved as a control group.

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