Prevalence of airway reversibility in connective tissue disease-interstitial lung disease (CTD-ILD)
Keywords:
prevalence airway reversibility, CTD-ILDAbstract
Background: Spirometry is the most reproducible and objective measurement of airflow limitation. Improvement in FEV1 and/or FVC by 12% or 200ml after using bronchodilator is definitive of reversible airway disease.[1] Several conditions like sarcoidosis predominantly involve the interstitium have nevertheless been associated with reversible airways obstruction. Connective tissue diseases (CTDs) form another important subgroup of interstitial lung disease(ILD). CTDs usually produce a restrictive pattern of lung involvement on spirometry, but might have unrecognized additional reversible airway obstruction. Seeking out and treating the latter components of disease may be crucial in optimizing lung function and alleviating the breathlessness that is common to the problem. Aim: The aim of this study is therefore to determine the post bronchodilator response in patients with connective tissue disease related interstitial lung disease (CTD-ILD) and thus potentially help improve quality of life by addressing the latter component by inhaled bronchodilator-steroid therapy. Methods: Consecutive patients with a confirmed diagnosis of CTD-ILD were identified in the out-patient clinics of our institute. CTD was diagnosed by a combination of clinical and serological parameters. ILD was confirmed by high resolution computed tomography (HRCT) images.
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A. Fischer, M. Strek, V. Cottin, P. Dellaripa, E. Bernstein, K. Brown, et al. Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease–Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities. Arthritis Rheumatol, 71 (2019), pp. 182-195
A. Olson, J. Swigris, D. Sprunger, A. Fischer, E. Fernandez-Perez, J. Solomon, et al. Rheumatoid Arthritis–Interstitial Lung Disease–associated Mortality. Am J Respir Crit Care Med, 183 (2011), pp. 372-378
D. Assayag, M. Lubin, J. Lee, T. King, H. Collard, C. Ryerson. Predictors of mortality in rheumatoid arthritis-related interstitial lung disease. Respirology, 19 (2014), pp. 493-500
R. E. Hyatt, C. T. Cowl, J. A. Bjoraker, and P. D. Scanlon (2009). Conditions associated with an abnormal nonspecific pattern of pulmonary function tests. Chest, 135(2):419-424.
R. Pellegrino, G. Viegi, V. Brusasco et al., “Interpretative strategies for lung function tests,” European Respiratory Journal, vol. 26, no. 5, pp. 948–968, 2005.
S. Mathai, S. Danoff. Management of interstitial lung disease associated with connective tissue disease. BMJ, 352 (2016), pp. h6819
S. Walsh, N. Sverzellati, A. Devaraj, G. Keir, A. Wells, D. Hansell. Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants. Thorax, 69 (2014), pp. 216-222
Sumer S Choudhary et al.2017, Study of Patients With Restrictive Spirometry Having Significant Bronchodilator Response. Int J Recent Sci Res. 8(6), pp. 17438-17442.
T. Winstone, D. Assayag, P. Wilcox, J. Dunne, C. Hague, J. Leipsic, et al. Predictors of mortality and progression in scleroderma-associated interstitial lung disease. Chest, 146 (2014), pp. 422-436
Uptodate 2021. Interpretation of DLCO
V. Steen, T. Medsger. Changes in causes of death in systemic sclerosis, 1972-2002.Ann Rheum Dis, 66 (2007), pp. 940-944
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