Design, synthesis, spectral analysis and molecular docking studies of some cyclic imide as potential anti breast and cervical cancer agents

Maha Abdul Razaq Essa; Adil Muala Dhumad

doi:10.53730/ijhs.v6nS10.13537

Authors

Maha Abdul Razaq Essa Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61001, Iraq
Adil Muala Dhumad Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61001, Iraq

Keywords:

cyclic imide, docking, breast cancer, cervical cancer, MCF-7, HeLa, DFT

Abstract

A number of cyclic imide derivatives were prepared in this study, using Diels- Alder reaction as a first step between maleic anhydride and anthracene. Use the reaction product as a reactant in the second step with different amines. The prepared cyclic imides were characterized by following the known spectroscopic methods to prove the proposed chemical composition of each of them using Mass, FT-IR, ¹HNMR and ¹³CNMR. The biological activity of the prepared cyclic imides was tested theoretically using molecular docking to prove their efficacy as candidate inhibitors of breast and cervical cancer. The efficacy of prepared cyclic imides as inhibitors and antagonists of breast and cervical cancer, a practical candidate using the MTT assay to measure cellular metabolic activity as an indicator of cell viability, proliferation and cytotoxicity in MCF-7 and HeLa cell lines. Cytotoxic effects were in agreement with the molecular docking calculations, as the prepared cyclic imide derivatives showed good activity in inhibiting breast and cervical cancer cells. The results of MTT assay and molecular docking scores proved that the prepared (11R,15S)-13-(3-nitrophenyl)-9,10-dihydro-9,10-[3,4]epipyrrolo-anthracene-12,14-di one derivative a3 is considered as a potential candidate inhibitor for cervical cancer.

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