The effect of administration of ethanol extract of talas kimpul stems ((Xanthosoma sagittifolium (l) schott)) on female wistar rats on hemoglobin level, erythrocyte level and birth weight of little wistar rats
Keywords:
birth weight, erythrocytes, hemoglobin, rat pups, Talas Kimpul stemsAbstract
Lack of nutritional intake of pregnant women is at risk of anemia and giving birth to low birth weight (LBW) babies. LBW is at risk of stunting. In 2018 the proportion of pregnant women experiencing anemia was 48.9%, stunting was 30.8%. This study aimed to determine the effect of giving ethanol extract of Kimpul taro stems ((Xanthosoma Sagittifolium (L.) Schott)) to female Wistar rats on hemoglobin levels, erythrocyte level, and birth weight of little rats. The Randomized Pretest Posttest Control Group Design. The population of this research is female Wistar rats aged 12-13 weeks, healthy, weight 170-180 g. Sampling technique: simple random sampling. The sample size of 25 was divided into five groups, namely Negative Control (KN), Positive Control (KP), Treatment 1 (P1), Treatment 2 (P2), and Treatment 3 (P3). The intervention duration is 4 weeks, using an oral sonde. Data analysis includes descriptive, bivariate, and multivariate, using computer assistance. The results: the average group pretest, hemoglobin levels 12.44-13.38 g/dL; erythrocyte levels 6.22 – 7.18 10^6/uL.
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References
Abbaspour, N., Hurrell, R., & Kelishadi, R. (2014). Review on iron and its importance for human health. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 19(2), 164-174.
Anand, K. J. S., Coskun, V., Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M. (1999). Long-term behavioral effects of repetitive pain in neonatal rat pups. Physiology & behavior, 66(4), 627-637. https://doi.org/10.1016/S0031-9384(98)00338-2
Badan penelitian dan Pengembangan Kesehatan Kementerian Kesehatan (2018) Hasil Utama Riskesdas 2018 Kesehatan. Jakarta: Kemenkes RI. Available at: http://www.depkes.go.id/resources/download/info-terkini/materi_rakorpop_2018/Hasil Riskesdas 2018.pdf.
Bappenas (2019) Rancangan Teknokratik Rencana Pembangunan Jangka Menengah Nasional 2020 - 2024 : Indonesia Berpenghasilan Menengah - Tinggi Yang Sejahtera, Adil, dan Berkesinambungan, Kementerian PPN/ Bappenas.
Budiani, N. N., & Armini, N. W. (2021). Nutritional, Phytochemical And Antinutritional Content Of Ethanol Extract Of Keladi/Talas Kimpul (Xanthosoma Sagittifolium (L.) Schott) And Keladi Togog (Colocasia Esculenta (L.) Schott) In Bali. Nveo-Natural Volatiles & Essential Oils Journal| NVEO, 13207-13215.
Cappellini, M. D., & Motta, I. (2015). Anemia in clinical practice—definition and classification: does hemoglobin change with aging?. In Seminars in hematology (Vol. 52, No. 4, pp. 261-269). WB Saunders. https://doi.org/10.1053/j.seminhematol.2015.07.006
Carreiro, A. L., Dhillon, J., Gordon, S., Higgins, K. A., Jacobs, A. G., McArthur, B. M., ... & Mattes, R. D. (2016). The macronutrients, appetite, and energy intake. Annual review of nutrition, 36, 73-103.
De Bernabé, J. V., Soriano, T., Albaladejo, R., Juarranz, M., Calle, M. E., Martı́nez, D., & Domı́nguez-Rojas, V. (2004). Risk factors for low birth weight: a review. European Journal of Obstetrics & Gynecology and Reproductive Biology, 116(1), 3-15. https://doi.org/10.1016/j.ejogrb.2004.03.007
de Souza Araújo, S., de Souza Araújo, P., Giunco, A. J., Silva, S. M., & Argandoña, E. J. (2019). Bromatology, food chemistry and antioxidant activity of Xanthosoma sagittifolium (L.) Schott. Emirates Journal of Food and Agriculture, 188-195.
Direktur, K. K. et al. (2010) Pedoman Pelayanan Antenatal Terpadu, Pedoman Pelayanan Antenatal Terpadu. Jakarta: Kemenkes RI.
Dulińska, I., Targosz, M., Strojny, W., Lekka, M., Czuba, P., Balwierz, W., & Szymoński, M. (2006). Stiffness of normal and pathological erythrocytes studied by means of atomic force microscopy. Journal of biochemical and biophysical methods, 66(1-3), 1-11. https://doi.org/10.1016/j.jbbm.2005.11.003
Eyasu, W., Tileye, T., & Kassahun, T. (2019). Proximate, mineral and anti-nutrient contents of cocoyam (Xanthosoma sagittifolium (L.) Schott. International Journal of Food Science, 10, 8965476.
John, M., Hoernig, S., Doehner, W., Okonko, D. D., Witt, C., & Anker, S. D. (2005). Anemia and inflammation in COPD. Chest, 127(3), 825-829. https://doi.org/10.1378/chest.127.3.825
John, S., Kale, M., Rathore, N., & Bhatnagar, D. (2001). Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes. The Journal of nutritional biochemistry, 12(9), 500-504. https://doi.org/10.1016/S0955-2863(01)00160-7
Ketaren, K. S. (2016). Uji efektivitas air kelapa muda (Cocos nucifera L.) terhadap hemoglobin pada tikus putih (Rattus norvegicus) sebagai anti anemia setelah diinduksi siklofosfamid. Jurnal Mahasiswa PSPD FK Universitas Tanjungpura, 5(1).
Luyckx, V. A., & Brenner, B. M. (2005). Low birth weight, nephron number, and kidney disease. Kidney International, 68, S68-S77. https://doi.org/10.1111/j.1523-1755.2005.09712.x
Marais, L., Van Rensburg, S. J., Van Zyl, J. M., Stein, D. J., & Daniels, W. M. (2008). Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neuroscience research, 61(1), 106-112. https://doi.org/10.1016/j.neures.2008.01.011
Moorthy, D., Merrill, R., Namaste, S., & Iannotti, L. (2020). The Impact of Nutrition-Specific and Nutrition-Sensitive Interventions on Hemoglobin Concentrations and Anemia: A Meta-review of Systematic Reviews. Advances in Nutrition, 11(6), 1631-1645.
Nadiyah, N., Meliala, E. M. S., Simanjuntak, A. C., & Perangin-Angin, F. (2021). Relationship between Characteristics and Nutrient Intake with Anemia among Pregnant Women at Kebon Jeruk Public Health Center, Jakarta. International Journal of Nursing and Health Services (IJNHS), 4(3), 303-312.
Nurjannah, T. A., Elba, F., Nirmala, S. A., Mandiri, A., & Wijaya, M. (2021). Relationship between Nutrition Intake and Hemoglobin Levels in Toddlers Aged 12-24 Months. Althea Medical Journal, 8(1), 13-17.
Olivier, B., Molewijk, H. E., Van der Heyden, J. A. M., Van Oorschot, R., Ronken, E., Mos, J., & Miczek, K. A. (1998). Ultrasonic vocalizations in rat pups: effects of serotonergic ligands. Neuroscience & Biobehavioral Reviews, 23(2), 215-227. https://doi.org/10.1016/S0149-7634(98)00022-0
Savarino, G., Corsello, A., & Corsello, G. (2021). Macronutrient balance and micronutrient amounts through growth and development. Italian Journal of Pediatrics, 47(1), 1-14.
Schober, M. E., Requena, D. F., Casper, T. C., Velhorst, A. K., Lolofie, A., McFarlane, K. E., ... & Gensel, J. C. (2019). Docosahexaenoic acid decreased neuroinflammation in rat pups after controlled cortical impact. Experimental neurology, 320, 112971. https://doi.org/10.1016/j.expneurol.2019.112971
Sherwood, L. (2010). Human Physiology from cells to systems.
Ufelle, S. A., Onyekwelu, K. C., Ghasi, S., Ezeh, C. O., Ezeh, R. C., & Esom, E. A. (2018). Effects of Colocasia esculenta leaf extract in anemic and normal wistar rats. Journal of Medical Sciences, 38(3), 102-106.
WHO. (2016). Rekomendasi WHO Dalam Pelayanan Antenal Care (ANC) Tweet ANC atau anteatal care merupakan perawatan ibu dan janin selama masa kehamilan. Seberapa penting dilakukan kunjungan ANC? Sangat penting. Melalui ANC berbagai informasi serta edukasi terkait kehamil. UK: WHO Press.
Wijaya, B. A., Citraningtyas, G., & Wehantouw, F. (2014). Potensi Ekstrak Etanol Tangkai Daun Talas (Colocasia Esculenta [L]) Sebagai Alternatif Obat Luka Pada Kulit Kelinci (Oryctolagus cuniculus), Pharmacon, 3(3), 211–219.
Zinatullina, A. M., Melnik, V. P., & Zimina, A. A. (2021). Personal factors of biological aging in working and non-working respondents in late maturity period. International Journal of Health Sciences, 5(3), 639–648. https://doi.org/10.53730/ijhs.v5n3.2790
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