Repaglinide and metformin (diabetic treatments) enhance sexual efficiency

Karrar salih mahdi; Farah Safaa Abdulhussein Alwan; Iman Jabber Hasen; Mustafa Jawad Al-Imari

doi:10.53730/ijhs.v6nS1.6307

Authors

Karrar salih mahdi Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
Farah Safaa Abdulhussein Alwan Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
Iman Jabber Hasen College of Viternary medicine, The_Qar University, Iraq
Mustafa Jawad Al-Imari Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq

Keywords:

diabetes, repaglinide, metformin, progressive motility, testosterone

Abstract

Diabetes mellitus type 2 (DMT2) is one of the modern societies’ highest public health threats. For a while, it was believed that DM had no impact on male reproductive function; however, new research has cast doubt on that assumption. To find out whether repaglinide and metformin may improve sperm motility and testosterone levels in diabetic and non-diabetic albino rats, researchers in this study used these two drugs to treat diabetes. Methods: Alloxan injections at three dosages of 120 mg/kg intraperitoneal produced type 2 diabetes in male rats. Experimental rats were classified into two main groups. The first group included four subgroups of male rats treated with alloxan (DM inducer). Each subgroup contained seven rats “1. Control without any treatment (positive control), 2. treated by 500 mg/kg metformin, 3. treated by 4 mg/kg repaglinide, and 4. treated by 500 mg/kg metformin and 4 mg/kg repaglinide”. The second group also includes four subgroups but without alloxan treated. Each subgroup has seven rats; all are categorized in the same initial group and receive identical treatment dosages.

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