Repaglinide and metformin (diabetic treatments) enhance sexual efficiency

https://doi.org/10.53730/ijhs.v6nS1.6307

Authors

  • Karrar salih mahdi Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
  • Farah Safaa Abdulhussein Alwan Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
  • Iman Jabber Hasen College of Viternary medicine, The_Qar University, Iraq
  • Mustafa Jawad Al-Imari Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq

Keywords:

diabetes, repaglinide, metformin, progressive motility, testosterone

Abstract

Diabetes mellitus type 2 (DMT2) is one of the modern societies’ highest public health threats. For a while, it was believed that DM had no impact on male reproductive function; however, new research has cast doubt on that assumption. To find out whether repaglinide and metformin may improve sperm motility and testosterone levels in diabetic and non-diabetic albino rats, researchers in this study used these two drugs to treat diabetes. Methods: Alloxan injections at three dosages of 120 mg/kg intraperitoneal produced type 2 diabetes in male rats. Experimental rats were classified into two main groups. The first group included four subgroups of male rats treated with alloxan (DM inducer). Each subgroup contained seven rats “1. Control without any treatment (positive control), 2. treated by 500 mg/kg metformin, 3. treated by 4 mg/kg repaglinide, and 4. treated by 500 mg/kg metformin and 4 mg/kg repaglinide”. The second group also includes four subgroups but without alloxan treated. Each subgroup has seven rats; all are categorized in the same initial group and receive identical treatment dosages.

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References

Abeeleh, M. A., Z. B. Ismail, K. R. Alzaben, S. A. Abu-Halaweh, M. K. Al-Essa, J. Abuabeeleh and M. M. Alsmady (2009). "Induction of diabetes mellitus in rats using intraperitoneal streptozotocin: a comparison between 2 strains of rats." Eur J Sci Res 32(3): 398-402.

Adaramoye, O., O. Akanni, O. Adesanoye, O. Labo-Popoola and O. Olaremi (2012). "Evaluation of toxic effects of metformin hydrochloride and glibenclamide on some organs of male rats." Nigerian journal of physiological sciences 27(2): 137-144.

Adaremoye, O. A. and S. O. Lawal (2014). "Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on the antioxidant, hormonal and spermatogenic indices of diabetic male rats." Andrologia 46(8): 878-886.

Al-Joubori, M. (2013). Histological and cytological effects of some plants extracts on hyperglycemic male rats. PhD, University of Babylon.

Al-Kuraishy, H. M. and A. I. Al-Gareeb (2016). "Erectile Dysfunction and Low Sex Drive in Men with Type 2 DM: The Potential Role of Diabetic Pharmacotherapy." Journal of clinical and diagnostic research : JCDR 10(12): FC21-FC26.

AL-Saily, H. (2018). Anti-Fertility, immune function and Cytotoxic Effects of Hibiscus rosa-sinensis Flower extract and Cyproterone acetate in Male Rats. PhD, University of Babylon.

Alves, M. G., A. D. Martins, L. Rato, P. I. Moreira, S. Socorro and P. F. Oliveira (2013). "Molecular mechanisms beyond glucose transport in diabetes-related male infertility." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832(5): 626-635.

Bolen, S., L. Feldman, J. Vassy, L. Wilson, H.-C. Yeh, S. Marinopoulos, C. Wiley, E. Selvin, R. Wilson and E. B. Bass (2007). "Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus." Annals of internal medicine 147(6): 386-399.

Brüning, J. C., D. Gautam, D. J. Burks, J. Gillette, M. Schubert, P. C. Orban, R. Klein, W. Krone, D. Müller-Wieland and C. R. Kahn (2000). "Role of Brain Insulin Receptor in Control of Body Weight and Reproduction." Science 289(5487): 2122-2125.

Chaudhury, A., C. Duvoor, V. S. Reddy Dendi, S. Kraleti, A. Chada, R. Ravilla, A. Marco, N. S. Shekhawat, M. T. Montales, K. Kuriakose, A. Sasapu, A. Beebe, N. Patil, C. K. Musham, G. P. Lohani and W. Mirza (2017). "Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management." Frontiers in Endocrinology 8.

Chougale, A. D., S. N. Panaskar, P. M. Gurao and A. U. Arvindekar (2007). "Optimization of Alloxan Dose is Essential to Induce Stable Diabetes for Prolonged Period." Asian Journal of Biochemistry 2(6): 402-408.

Erhirhie, E. O., N. E. Ekene and D. L. Ajaghaku (2014). "Guidelines on dosage calculation and stock solution preparation in experimental animals' studies." Journal of Natural Sciences Research 4(18): 100-106.

Etuk, E. and B. Muhammed (2010). "Evidence based analysis of chemical method of induction of diabetes mellitus in experimental rats." International Journal of Research in Pharmaceutical Sciences 1(2): 139-142.

Fang, X., Q.-Y. Xu, C. Jia and Y.-F. Peng (2012). "[Metformin improves epididymal sperm quality and antioxidant function of the testis in diet-induced obesity rats]." Zhonghua nan ke xue = National journal of andrology 18(2): 146-149.

Ganesh, T., S. Sen, T. E, T. G, L. T and R. Chakraborty (2010). "Pharmacognostic and anti-hyperglycemic evaluation of Lantana camara (L.) var. aculeate leaves in alloxan-induced hyperglycemic rats." International Journal of Research in Pharmaceutical Science 1(3): 247-252.

Guardado-Mendoza, R., A. Prioletta, L. M. Jiménez-Ceja, A. Sosale and F. Folli (2013). "The role of nateglinide and repaglinide, derivatives of meglitinide, in the treatment of type 2 diabetes mellitus." Archives of medical science : AMS 9(5): 936-943.

Gumieniczek, A. (2005). "Effects of repaglinide on oxidative stress in tissues of diabetic rabbits." Diabetes Research and Clinical Practice 68(2): 89-95.

Gumieniczek, A., H. Hopkała and M. Pruchniak (2007). "Oxidative stress in the testis of hyperglycemic rabbits treated with repaglinide." Central European Journal of Biology 2(4): 538-546.

Inzucche, S. E., R. M. Bergenstal, J. B. Buse, M. Diamant, E. Ferrannini, M. Nauck, A. L. Peters, A. Tsapas, R. Wender and D. R. Matthews (2012). "Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)." Diabetologia 55(6): 1577-1596.

Khawandanah, J. (2019). "Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors." Nutr Diabetes 9(1): 33.

Kumar, N., S. Jain, A. Gupta and A. K. Tiwary (2008). "Spermicidal activity of sulfonylureas and meglitinide analogues: role of intrasperm Ca2+ elevation." Journal of Pharmacy and Pharmacology 60(3): 323-330.

Kurzthaler, D., D. Hadziomerovic-Pekic, L. Wildt and B. E. Seeber (2014). "Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects." Reproductive Biology and Endocrinology 12(1): 98.

Lebovitz, H. E. and A. Melander (2015). Sulfonylureas and meglitinides: insights into physiology and translational clinical utility. International Textbook of Diabetes Mellitus: 615-640.

Macdonald Ighodaro, O., A. Mohammed Adeosun and O. Adeboye Akinloye (2017). "Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies." Medicina 53(6).

Malin, S. K. and S. R. Kashyap (2014). "Effects of metformin on weight loss: potential mechanisms." Current Opinion in Endocrinology, Diabetes and Obesity 21(5): 323-329.

Malone, M. (2005). "Medications Associated with Weight Gain." Annals of Pharmacotherapy 39(12): 2046-2055.

Mangoli, E., A. R. Talebi, M. Anvari and M. Pourentezari (2013). "Effects of experimentally-induced diabetes on sperm parameters and chromatin quality in mice." Iranian journal of reproductive medicine 11(1): 53-60.

Masiello, P. (2006). "Animal models of type 2 diabetes with reduced pancreatic β-cell mass." The International Journal of Biochemistry & Cell Biology 38(5): 873-893.

Mattack, N., R. Devi, T. Kutum and D. Patgiri (2015). "The evaluation of serum levels of testosterone in type 2 diabetic men and its relation with lipid profile." Journal of clinical and diagnostic research : JCDR 9(1): BC04-BC07.

Moses, R., R. Slobodniuk, S. Boyages, S. Colagiuri, W. Kidson, J. Carter, T. Donnelly, P. Moffitt and H. Hopkins (1999). "Effect of repaglinide addition to metformin monotherapy on glycemic control in patients with type 2 diabetes." Diabetes Care 22(1): 119-124.

Nair, A. B. and S. Jacob (2016). "A simple practice guide for dose conversion between animals and human." Journal of basic and clinical pharmacy 7(2): 27-31.

Nak-ung, S., N. Nakprom, C. Maneengam, S. Nudmamud-Thanoi and S. Thanoi (2018). "Changes in sperm quality and testicular structure in a rat model of type 1 diabetes." Asian Biomedicine 12(4): 141-147.

Nelli, G. B. and E. K. Kilari (2013). "Antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin induced diabetic male rats." Systems Biology in Reproductive Medicine 59(6): 319-328.

Ozata, M., C. Oktenli, N. Bingol and I. C. Ozdemir (2001). "The Effects of Metformin and Diet on Plasma Testosterone and Leptin Levels in Obese Men." Obesity Research 9(11): 662-667.

RamkishanJat, Mandaviagarwal, Navnitagarwal, Nutanagarwal, Kuldeepchandel and Z. siddiqui (2014). "Comparison Of Serum Testosterone, Luteinizing Hormone And Follicle Stimulating Hormone Levels In Diabetics And Non-Diabetics Men –A Case –Control Study." IOSR Journal of Dental and Medical Sciences (IOSR-JDMS 13(Issue 5 Ver. III. (May. 2014)): 65-71.

Ravi, K., S. Rajasekaran and S. Subramanian (2005). "Antihyperlipidemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats." Food and Chemical Toxicology 43(9): 1433-1439.

Resmi, C., M. Venukumar and M. Latha (2006). "Antioxidant activity of Albizzia lebbeck (Linn.) Benth. in alloxan diabetic rats." Indian journal of physiology and pharmacology 50(3): 297.

Ribas-Maynou, J. and M. Yeste (2020). "Oxidative Stress in Male Infertility: Causes, Effects in Assisted Reproductive Techniques, and Protective Support of Antioxidants." Biology 9(4): 77.

Sacks, D. B., M. Arnold, G. L. Bakris, D. E. Bruns, A. R. Horvath, M. S. Kirkman, A. Lernmark, B. E. Metzger and D. M. Nathan (2011). "Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus." Clinical Chemistry 57(6): e1-e47.

Saltiel, A. R. and C. R. Kahn (2001). "Insulin signalling and the regulation of glucose and lipid metabolism." Nature 414(6865): 799-806.

Scotte, L. J. (2012). "Repaglinide." Drugs 72(2): 249-272.

Shegem, N. S., A. M. Nasir, A. Jbour, A. M. Batieha, M. El-Khateeb and K. M. Ajlouni (2002). "Effects of short term metformin administration on androgens in normal men." Saudi medical journal 23(8): 934-937.

Shpakov, A. O. (2021). "Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms." Pharmaceuticals 14(1): 42.

Singh, S., T. Malini, S. Rengarajan and K. Balasubramanian (2009). "Impact of experimental diabetes and insulin replacement on epididymal secretory products and sperm maturation in albino rats." Journal of Cellular Biochemistry 108(5): 1094-1101.

Stevanovic, D., K. Janjetovic, M. Misirkic, L. Vucicevic, M. Sumarac-Dumanovic, D. Micic, V. Starcevic and V. Trajkovic (2012). "Intracerebroventricular Administration of Metformin Inhibits Ghrelin-Induced Hypothalamic AMP-Kinase Signalling and Food Intake." Neuroendocrinology 96(1): 24-31.

Tankova, T., D. Koev, L. Dakovska and G. Kirilov (2003). "The effect of repaglinide on insulin secretion and oxidative stress in type 2 diabetic patients." Diabetes Research and Clinical Practice 59(1): 43-49.

Tanquilut, N., M. Tanquilut, M. Estacio, E. Torres, J. Rosario and B. Reyes (2009). "Hypoglycemic effect of Lagerstroemia speciosa (L.) Pers. on alloxan-induced diabetic mice." Journal of Medicinal Plants Research 3(12): 1066-1071.

Tavares, R., S. Escada-Rebelo, M. Sousa, A. Silva, J. Ramalho-Santos and S. Amaral (2019). "Can antidiabetic drugs improve male reproductive (dys) function associated with diabetes?" Current medicinal chemistry 26(22): 4191-4222.

Valsamakis, G., K. Lois, S. Kumar and G. Mastorakos (2013). "Metabolic and other effects of pioglitazone as an add-on therapy to metformin in the treatment of polycystic ovary syndrome (PCOS)." Hormones 12(3): 363-378.

Varley, H., A. Gowenlock and M. Bell (1991). Practical clinical biochemistry (vol 1; 5th edn). Heinemann, London, Tonbridge (UK): White Trias Press.

WHO (2010). World Health Organization (WHO) laboratory manual for the examination and processing of human semen. Geneva, World Health Organization, Cambridge, Cambridge University Press.

Yerevanian, A. and A. A. Soukas (2019). "Metformin: Mechanisms in Human Obesity and Weight Loss." Current Obesity Reports 8(2): 156-164.

Published

28-04-2022

How to Cite

mahdi, K. salih, Alwan, F. S. A., Hasen, I. J., & Al-Imari, M. J. (2022). Repaglinide and metformin (diabetic treatments) enhance sexual efficiency. International Journal of Health Sciences, 6(S1), 6292–6308. https://doi.org/10.53730/ijhs.v6nS1.6307

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