Effect of SARS-Cov2 on copper and zinc element in patients with liver and kidney disease

https://doi.org/10.53730/ijhs.v6nS5.9067

Authors

  • Zahraa Nassr Jawad Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
  • Zahraa Majid Abd- Alameer Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
  • Zahraa Aqeel Muslim Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq
  • Rusl Mahdi Obaid Medical Laboratory Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babil, Iraq

Keywords:

COVID-19, copper, zinc

Abstract

The objective of the present study was to evaluate of serum metal levels such as copper and zinc in COVID-19 patients with liver and kidney disease. This study included 37 sample divided in to two group epidemiology and liver, kidney group. the result of this study  The result of this study show that the significant level of zinc  and copper between patients and control with COVID 19 epidemiology and significant effect of COVID on  level of zinc and copper in patients with liver, kidney disease patient , the mean of zinc in patients with COVID was  177.32 and 12.58 in control , the mean of copper in patients was 70.47 and 19.32 in control , in patients with liver and kidney disease the mean of zinc in patients was 257.33  and 12.58 in control , the mean of copper in patients was 74.33  and 19.32 in control. The study conclude that level of serum zinc and copper were increase in patient with COVID-19 and liver, kidney function disease compare to control.

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References

Wiersinga W.J., Rhodes A., Cheng A.C., Peacock S.J., Prescott H.C. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review. JAMA. 2020;324(8):782–793.

Henderson, L.A.; Canna, S.W.; Schulert, G.S.; Volpi, S.; Lee, P.Y.; Kernan, K.F.; Caricchio, R.; Mahmud, S.; Hazen, M.M.; Halyabar, O.; et al. On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis Rheumatol. 2020, 72, 1059–1063.

Velthuis, A.J.W.T.; Worm, S.H.E.V.D.; Sims, A.C.; Baric, R.S.; Snijder, E.J.; Van Hemert, M.J. Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture. PLoS Pathog. 2010, 6, e1001176

Grochowski, C.; Blicharska, E.; Krukow, P.; Jonak, K.; Maciejewski, M.; Szczepanek, D.; Jonak, K.; Flieger, J.; Maciejewski, R. Analysis of trace elements in human brain: Its aim, methods, and concentration levels. Front. Chem. 2019, 7, 115.

Leoni, G.; Rosato, A.; Perozzi, G.; Murgia, C. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutr. 2014, 9, 436.

Kardos J, Héja L, Simon Á, Jablonkai I, Kovács R, Jemnitz K (2018) Copper signalling: causes and consequences. CCS 16(1):1–22

Krawczyk-Coda , M .(2019). Determination of Selenium in Food Samples by High-Resolution Continuum Source Atomic Absorption Spectrometry After Preconcentration on Halloysite Nanotubes Using Ultrasound-Assisted Dispersive Micro Solid-Phase Extraction Food Analytical Methods .12,128-135

Ozra Bagher Pour ., Yahya Yahyavi., Abbas Karimi ., Amir Mehdi Khamaneh ., Mortaza Milani ., Majid Khalili ., Akbar Sharif.(2021). International Journal of Infectious Diseases.111,164-168

Irena D. Ivanova, Amit Pal, Ilaria Simonelli, Bisera Atanasova, Mariacarla Ventriglia, Mauro Rongioletti, and Rosanna Squitti .(2022).Evaluation of zinc, copper, and Cu:Zn ratio in serum, and their implications in the course of COVID-19

,M.,Brito, A ., Dingeo G ., Fernandez Del Campo ,S.S.,Samouda H .,La Frano MR .et al.(2020).Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: considerations during the COVID-19 crisis. Nutrients ; 12: 1562

Rahman ,M.T .,Idid ,S.Z.(2020).Can Zn be a critical element in COVID-19 treatment?.Biological trace element research ; : 1-9

Kiran Kumar PVSN1 Sojit Tomo1 Purvi Purohit1 • Shrimanjunath Sankanagoudar1 • Jayakaran Charan2 • Abhishek Purohit3 • Vijaylakshami Nag4 • Pradeep Bhatia5 • Kuldeep Singh6 • Naveen Dutt7 • Mahendra Kumar Garg8 • Praveen Sharma1 • Sanjeev Misra9 • Dharamveer Yadav.(2022). Comparative Analysis of Serum Zinc, Copper and Magnesium Level and Their Relations in Association with Severity and Mortality in SARS CoV 2 Patients. Biological Trace Element Research https://doi.org/10.1007/s12011-022-03124-7

Arrieta F, Martinez-Vaello V, Bengoa N, et al. Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition. Nutrition. 2021;91-92:111467. doi:10.1016/j.nut.2021.111467

Anuk, A.T., Polat, N., Akdas, S. et al. The Relation Between Trace Element Status (Zinc, Copper, Magnesium) and Clinical Outcomes in COVID-19 Infection During Pregnancy. Biol Trace Elem Res 199, 3608–3617 (2021).

Satarug , S ., Baker , J.R ., Reilly, P.E.B ., Moore , MR and Williams, D.J.(2001). Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium .Human & Experimental Toxicology (2001) 20, 205-213

Published

16-06-2022

How to Cite

Jawad, Z. N., Abd- Alameer, Z. M., Muslim, Z. A., & Obaid, R. M. (2022). Effect of SARS-Cov2 on copper and zinc element in patients with liver and kidney disease. International Journal of Health Sciences, 6(S5), 2016–2020. https://doi.org/10.53730/ijhs.v6nS5.9067

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Section

Peer Review Articles