Assessment of liver function enzymes, MDA and GSH in the Sera of COVID-19 patients

Sara Jassim Mohammed; Falah S. AL-Fartusie

doi:10.53730/ijhs.v6nS5.9623

Authors

Sara Jassim Mohammed Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad-Iraq
Falah S. AL-Fartusie
sci.falah.al_fartusie@uomustansiriyah.edu.iq
Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad-Iraq

Keywords:

COVID-19, liver enzymes, Glutathione, MDA

Abstract

A cluster of unexplained pneumonia cases was reported in Wuhan, China, in late December 2019. A new coronavirus was identified as the causative cause of this mysterious pneumonia a few days later. The World Health Organization has temporarily given this causal virus the designation of severe acute respiratory syndrome coronavirus 2 and the related infected disease as coronavirus disease 2019 (COVID-19). The primary objective of this study is to examine the liver efficiency and assess the oxidative stress status of COVID-19 patients by measuring liver function enzymes, glutathione and MDA. The study included 120 cases ranging from 20 to 60 years, divided into three groups, COVID-19 patients, recovered, and control groups. Group. The results obtained indicated a significant increase in ALT, AST, and ALP activity (p< 0.01) in patients compared to those recovering and control. The results also indicated a significant increase in MDA in contrast to a significant decrease in the GSH activity of COVID-19 patients compared to recovered and healthy subjects. These results reflect the strong relationship between COVID-19 and impaired liver function as well as impaired oxidative stress / antioxidant balance.

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