Phytochemical and pharmacological investigation of some medicinal plants for the treatment of hepatoprotective & antioxidant activity
Keywords:
Luffa amara fruit extracts, Anti-diabetic activity, CCl4, Hepatoprotective activity, Antimicrobial activityAbstract
The plant Luffa acutangula var. Amara is used by native practitioners. Presently, it is planned to make petroleum ether, alcohol, and aqueous extracts of this plant's fruits before undertaking blind screening trials to examine the antidiabetic, hepatoprotective, and antibacterial effects of the fruits and validate native practitioners' claims. The powdered whole fruits were extracted with petroleum ether, alcohol and chloroform water. The LD50 values for all these extracts were found to be 70 mg/kg, 500 mg/kg, and 15g/kg respectively. Alloxan-induced diabetes in 150-200g albino rats was tested for antidiabetic effects and compared to glibenclamide. Albino rats treated with CCl4, a liver toxicant, had increased SGOT, SGPT, SALP, direct and total bilirubin, serum cholesterol, and serum triglyceride levels. Compared to CCl4-treated group, findings were significant. In a CCl4 hepatotoxic model, alcoholic and aqueous extracts significantly decreased wet liver weight and volume, indicating hepatoprotective action. Histopathological abnormalities (fatty infiltration, necrosis, etc.) were normalised in aqueous and alcoholic extract groups.
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