Psychological effects of COVID-19 on patients with cancer, their caregivers

A systematic review

https://doi.org/10.53730/ijhs.v6nS6.10109

Authors

  • P. Kishore Kumar Associate Professor, CMR college of Pharmacy, Hyderabad. Telangana. India-501401
  • J. Ashwini Assistant Professor, University college of Pharmaceutical Sciences, Satavahana University, Karimnagar, Telangana. India -505001
  • Archana G. L. Assistant Professor, University college of Pharmaceutical Sciences, Satavahana University, Karimnagar, Telangana. India -505001
  • K. Lakshmi Professor & Dean, Chettinad School of Pharmaceutical Sciences, Chettinad Academy of Research and Education, Chettinad Health city, Kelambakkam, Chengalpattu (Dist.) Tamil Nādu, India -603103
  • R. Suthakaran Professor& Principal, Department of Pharmaceutical Chemistry, Vijaya College of Pharmacy, Munganoor (v), Hayathnagar (M), Hyderabad, Telangana, India -501511
  • M. Akiful Haque Associate professor, Anurag University, Venkatapur, Ghatkesar, Hyderabad, Telangana. India-500088
  • Teja Kumar Reddy Konatham Research Scholar, Anurag University, Venkatapur, Ghatkesar, Hyderabad, Telangana India-500088
  • Gollapalli Rajeev Kumar Assistant professor, Anurag University, Venkatapur, Ghatkesar, Hyderabad, Telangana India-500088

Keywords:

stress, anxiety, depression, COVID-19, cancer caregivers, cancer patients, systematic review

Abstract

There is limited study reporting the severity of anxiety and depression in cancer cohort and their caregivers. We aimed in this systematic review to determine the prevalence of stress, anxiety, depression among comprehensive cancer patient and their caregivers during COVID-19 pandemic. A systematic review search was performed on PubMed, PsycINFO, CINAHL, and Scopus till June 2021. PRISMA guidelines were used in this systematic review. Reviews were performed to collect all original research articles to describe prevalence of stress, anxiety, depression among the cancer patients and their caregivers. All analysis was done by using RStudio version 1.0.136. 4 studies from our search criteria were eligible for inclusion for anxiety symptoms. Meta-analyses revealed that no any significant difference in incidence of anxiety in cancer and their caregivers. The pooled odds ratio 1.00 [95% CI; 0.87- 1.15]. Pooled prevalence in patients and their caregivers 49% [25%; 74%] and 50% [26%; 73%] respectively.  Anxiety was relatively higher in cancer patients and their care givers. Isolation, married caregivers showed most significant factor to increase anxiety in cancer patients and their care givers. This metaanalyses suggest that prevalence of anxiety in cancer patients and their caregivers were significantly increasing during COVID-19.

Downloads

Download data is not yet available.

References

Bai,Y., Lin, C.C., Lin, C.Y., Chen. J.Y, Chue, C.M., & Chou, P.(2004). Survey of stress reactions among health care workers involved with the SARS outbreak. Psychiatr Serv 55(9): 1055-1057. doi:10.1176/appi.ps.55.9.1055

Bayliss, E.A., Steiner, J.F., Fernald, D.H., Crane, L.A., & Main, D.S. (2003). Description of barriers to self-care by persons with comorbid chronic diseases. Ann. of Family Med 1,(1) :15–21.

Biagi, J.J., Raphael, M.J., Mackillop, W.J., Kong, W., King, W.D., & Booth, C.M. (2011). Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer: a systematic review and meta-analysis. JAMA, 305: 2335-42. 10.1001/jama.2011.749

Bleicher, R.J., Ruth, K., Sigurdson, E.R., Robert, B.J., Ross, E., Wong, Y.N., Patel, S.A., Boraas, M., Chang, E.I., Topham, N.S., & Egleston, B.L. (2016). Time to Surgery and Breast Cancer Survival in the United States. JAMA Oncol, 2: 330-339. 10.1001/jamaoncol.2015.4508

Boberg, E.W., Gustafson, D.H., Hawkins, R.P., Kenneth, P.O., Courtney ,K., Kuang, Y.W., Kendra, K., & Andrew, S. (2003). Assessing the unmet information, support and care delivery needs of men with prostate cancer. Patient Edu. and Counsel, 49(3): 233–242.

Brandenbarg, D., Maass, S., Geerse, O.P., Stegmann, M.E., Handberg, C., Schroevers, M.J., & Duijts. (2019). A systematic review on the prevalence of symptoms of depression, anxiety and distress in long-term cancer survivors: implications for primary care. Eur J Cancer Care, 28(3):e13086.

Chen, N., Min, Zhou., Xuan, dong., Jieming, Qu., Fengyun, Gong., Yang, Han., Yang, Qiu., Jingli, Wang., Ying, Liu., Yuan, Wei., Jia’an, Xia., Ting, Y.u., Xinxin, Zhang., & Li Zhang. (2020).Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 395: 507–513

Carlisle, P.S., Gucalp, R., & Wiernik, P.H. (1993). Nosocomial infections in neutropenic cancer patients. Infect Control Hosp Epidemiol,14: 320–324.

Chen, Z., King, W., Pearcey, R., Kerba, M., & Mackillop, W.J. (2008). The relationship between waiting time for radiotherapy and clinical outcomes: a systematic review of the literature. Radiother Onco, 87:3-16.

Dai, M.Y., Liu, D., Liu, M., Miao, L., Fuxiang, Z., Guiling, Li., Zhen, C., Zhian, Z., Hua, Meng, Wu., Qichao., Yong. , Huihua, Xi., Chun, W., Changchun., Fei, Xi., Yan, Z., Yaqin, P., Siping, Ge., Bo, Zhen., Tingting, Yu., Ling, W., Hua, W., Yu, Liu., Yeshan, Chen,. Junhua, M., Xiaojia, G., Zhuyan, L., Lijuan, G., Can, He., Zhen, Li., Yuying, Shi., Yuwen, Q., Jing, Y., Daniel, G.T., Li, Chai,, Lorelei, A., Mauricio., & Hongbing, C. (2020). Patients with cancer appear more vulnerable to SARS-CoV-2: a multi center study during the COVID-19 outbreak. Cancer Discov, 10(6):783-791 published online April 28. DOI:10.2139/ssrn.3558017

Eakin, E.G., & Strycker, L.A.(2001). Awareness and barriers to use of cancer support and information resources by HMO patients with breast, prostate, or colon cancer: Patient and provider perspectives. Psycho-Oncology, 10(2):103–113.

El-Sharif, A., Elkhatib, W.F., & Ashour, H.M. (2012). Nosocomial infections in leukemic and solid-tumor cancer patients: distribution, outcome and microbial spectrum of anaerobes. Future Microbiol, 7: 1423–1429.

Faggioli, P., De, Paschale, M., Tocci, A., Luoni, M.,Fava, S., A, De, Paoli., Tosi, A., & Cassi, E.(1997). Acute hepatic toxicity during cyclic chemotherapy in non-Hodgkin’s lymphoma. Haematologica, 82: 38–42.

Fujii, Y., Kaku, K., Tanaka, M., Yosizaki, M., Kaneko, T., & Matumoto, N.(1994). Hepatitis C virus infection in patients with leukemi. Am J Hematol, 46: 278–282.

Harapan, H., Itoh, N., Yufika, A., Winardi, W., Synat, Keamg., Haypheng, Th., Dewi, Megawatii,j., Zinatul, Hayati., Abram, L.W., & Mudatsir, Mudatsi. (2020). Coronavirus disease 2019 (COVID-19). A liter rev. J of Inf and Pub Health, 13 (5): 667–673.

Huang, C., Yeming, wang., Xingwango, Li., Lili, Ren., Jianping, Zhao., Yi, Hu., Li, Zhang., Guohui, Fan., Jiuyang, Xu., Xiaoying, Gu., Zhenshun, Cheng., Ting, Yu., Jiaan, Xia., Yuan, Wei., Wenjuan, Wu., Xuelei, Xie., Wen, Yin., Hui, Li., Min, Liu., Yan, Xiao., Hong, Gao., Li, Guo., Jungang, Xie., Guangfa, Wang., Rongmeng, Jiang., Zhancheng, Gao., Qi, Jin., Jianwei, Wang., & Bin, Cao. (2020).Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395: 497–506.

Institute of Medicine Committee on Quality of Health Care in America, Crossing the quality chasm: a new health system for the 21st century, National Academy Press, 2001.

Kamboj, M.,& Sepkowitz, K.A. (2009). Nosocomial infections in patients with cancer. Lancet Oncol, 10: 589–597.

Lescure, F.X., Bouadma, L., Nguyen. D., Marion, P., Paul, H.W., Sylvie, B., Alexandre, G., Maude, B.D., Flora, D., Quentin. L., Hingrat., Vincent, E., Nadhira, H.F., Martine, V., Alexandra, M., Jean, C. L., France, M., Xavier Duval., Diane, D., Denis, M., Jean, F.T., Bruno, L., Sylvie, v., & Yazdan, Y.(2020). Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect. Dis, 20: 697–706.

Liang, W., Guan, W., Chen, R., Wei, W., Jianfu, Li., Ke, Xu., Caichen, Li., Qing, Ai., Weixiang, Lu., Hengrui, Shiyue, Li., & Jianxing, H. (2020). Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol, 21: 335–37.

Loeffen, E., Knops, R., Boerhof, J., E.A.M.Feijen., Johannes, H.M., Ardine, M.J.R., Jan, A.L., Rob, P. H., Marike, B., Leontien, C., & Wim, J.E.T.(2019). Treatment-related mortality in children with cancer: Prevalence and risk factors.Euro. J. of Cancer, 121:113–122.

Mallinger, J,B., Griggs, J.J., & Shields, C.G. (2005). Patient-centered care and breast cancer survivors’ satisfaction with information. Patient Edu. and Counsel, 57(3): 342–349.

Markovic, S., Drozina, G., Vovk, M., & Fidler, J. M.(1999). Reactivation of hepatitis B but not hepatitis C in patients with malignant lymphoma and immunosuppressive therapy. A prospective study in 305 patients. Hepatogastroenterology ,46: 2925–2930.

Maunder, R., Hunter, J., Vincent, L., Bennett, J., Peladeau, N., Leszcz, M., Sadavoy, J., Verhaeghe, L., Steinberg, R., & Mazzulli, T.(2003). The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital. CMAJ, 168(10): 1245-1251.

OECD (2020), OECD Economic outlook, Interim Report September 2020, OECD Publishing, Paris. Available at http://dx.doi.org/10.1787/34ffc900-n

Raphael, M.J., Biagi, J.J., Kong, W., Mates, M., Booth, C.M., & Mackillop. (2016). The relationship between time to initiation of adjuvant chemotherapy and survival in breast cancer: a systematic review and meta-analysis. Breast Canc. Res Treat,160: 17-28.

Riegel, B., & Carlson, B. (2002). Facilitators and barriers to heart failure self-care. Patient Edu and Counsel, 46(4): 287–295.

Skalla, K.A., Bakitas, M., Furstenberg, C.T., Ahles, T., & Henderson, J.V. (2004). Patients’ need for information about cancer therapy. Onc. Nurs. For, 31(2): 313–319.

Van, de, Haar, J., Hoes, L,R., Coles, C.E,, Kenneth, S., Stefan, F., Dirk., Franco, V., Filippo, d., Luigi, D. P., Jonas, B., Ingemar, E., Benjamin, B., Fabrice, B., Elena, G., Alejandro, P., Michael., Giovanni., Jean, C.S., Josep, T., Carlos, C., & Emile, E. V.( 2020). Caring for patients with cancer in the COVID-19.Nat Med, 26: 665–71.

Walker, J., Holm, Hansen, C., Martin, P., Sawhney, A., Thekkumpurath, P., Beale, C., Symeonides, S., Wall, L., Murray, G., & Sharpe, M. (2013). Prevalence of depression in adults with cancer: a systematic review. Ann Oncol: official J. of the Eur. Society for Medi Onco, 24(4):895–900.

Wang, C., Pan, R., Wan, X., Tan, Y., Linkang, X., Cyrus, S.H., & Roger, C. H. (2020).Immediate Psychological Responses and Associated Factors during the Initial Stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Int J Environ Res Public Health, 17(5):1729. Published 2020 Mar 6. doi:10.3390/ijerph17051729

Watts, S., Leydon, G., Birch, B., Prescott, P., Lai, L., Eardley, S., & Lewith, G. (2014).Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates. BMJ Open, 4(3):e003901.

Watts, S., Prescott, P., Mason, J., McLeod, N., & Lewith, G. (2015). Depression and anxiety in ovarian cancer: a systematic review and meta-analysis of prevalence rates. BMJ Open, 5(11):e007618.a.

Wdowik, M.J., Kendall, P.A., & Harris, M.A. (1997). College students with diabetes: Using focus groups and interviews to determine psychosocial issues and barriers to control. The Diabetes Edu, 23(5):558–562.

World Health Organization. Coronavirus disease 2019 (COVID-19) situation report 48. 2020. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200308-sitrep-48-covid-19.pdf?sfvrsn=16f7ccef_4. Accessed March 31, 2020.

Quteimat, O.M., & Amer, A.M. (2020). The Impact of the COVID-19 Pandemic on Cancer Patients. Am J Clin Oncol, 43(6): 452-455.

Yang, Y,L., Liu, L., Wang, Y., Wu, H., Yang, X.S., Wang, J.N., & Wang, L. (2013). The prevalence of depression and anxiety among Chinese adults with cancer: a systematic review and meta-analysis. BMC Cancer, 13:393.

Published

01-07-2022

How to Cite

Kumar, P. K., Ashwini, J., Archana, G. L., Lakshmi, K., Suthakaran, R., Haque, M. A., Konatham, T. K. R., & Kumar, G. R. (2022). Psychological effects of COVID-19 on patients with cancer, their caregivers: A systematic review. International Journal of Health Sciences, 6(S6), 475–488. https://doi.org/10.53730/ijhs.v6nS6.10109

Issue

Section

Peer Review Articles