Synthesis and anti-diabetic activity evaluation of new 1,2,3-triazole derivatives incorporating 2-pyrazoline ring

Hawraa A. Mazyed; Ali S. Razzaq; Ghina H. Hussein; Riyadh J. Nahi

doi:10.53730/ijhs.v6nS4.10171

Authors

Hawraa A. Mazyed Department of Chemistry, College of Science, AL-Muthanna University, Iraq
Ali S. Razzaq College of Pharmacy, AL-Muthanna University, Iraq
Ghina H. Hussein Ministry of Education, Directorate of Education Al-Muthanna, Iraq
Riyadh J. Nahi
riyadhnahi@mu.edu.iq
College of Medicine/AL-Muthanna University, Iraq

Keywords:

heterocyclic compounds, 1,2,3-triazole, pyrazolines, furan ring

Abstract

In the present work, a new series of compounds containing 1,2,3-triazole and 2-pyrazoline moieties in the same matrix was synthesized via a multistep synthetic route. The synthesized compounds were characterized by FT-IR, ¹HNMR and ¹³C NMR spectra. The target compounds and their precursors were screened in vitro for their α-amylases inhibitory activity. The preliminary activity results revealed that all the tested compounds displayed an inhibition activity ranged from moderate to high depending on their structures and concentrations compared to ascorbose as a standard drug.

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