Development and evaluation of ligand Binded Phytoactive extract loaded SLN for brain targeting
Abstract
Drug delivery to the brain is the process of passing therapeutically active molecules across the Blood Brain Barrier for the purpose of treating brain disease. This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the Blood Brain Barrier. In response to the insufficiency in conventional delivery mechanisms, aggressive research efforts have recently focused on the development of new strategies to more efficiently deliver drug molecules to the CNS.The objective of present work deals with the preparation ofdevelopment and evaluation of ligand binded phytoactive extract loaded SLN for brain targeting.Solid lipid nanoparticles (SLNs) are spherical solid lipid nanoparticles in nanorange, easiy dispersibe in water or in aqueous surfactant solution present themselves as suitable candidate for drug delivery to the brain. These nanoparticles can easily penetrate blood brain barrier (BBB) and has good stability & lesser toxicity. In present work, phytoactive loaded SLN conjugated with lactoferrin was prepared by solvent evaporation method and was characterized for particle size, drug loading entrapment, ligend binding & targetability to brain cells.
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Ghada Abdelbary and Rania HF. Nanoparticles: A Review. AAPS Pharm. Sci. Tech 2009; 10(1): 51-63.
Reddy LH, Murthy RS. Etoposide-loaded Nanoparticles made from Glyceride Lipids: Formulation, Characterization, in-vitro drug release and stability evaluation. AAPS Pharm Sci Tech 2005; 6: E158-E166. http://dx.doi.org/10.1208/pt060224.
Jenning V, Gohla SH, Lippacher A. Medium scale production of Solid Lipid Nanoparticles (SLN) by high Pressure Homogenization. Journal of Microencapsulate 2002; 19: 1-10. http://dx.doi.org/10.1080/713817583.
Swathi, G., Prasanthi, N.L., Manikiran, S.S., Ramarao, N. (2010). Solid lipid nanoparticles: colloidal carrier systems for drug delivery. IJPSR 1(12): 01-16.
Sarathchandiran, I. (2012). A Review on Nanotechnology in Solid Lipid Nanoparticles IJPDT 2(1): 45-61.
Mulla, J.S., Khazi, I.M., Jamakandi, V.G. (2010). Solid lipid nanoparticles: Potential applications IJNDD 2(3): 82-87.
Rupenagunta, A., Somasundaram, I., Ravichandiram, V., Kausalya, J., Senthilnathan, B. (2011). Solid lipid nanoparticles- A versatile carrier system. J Pharm Res. 4(7): 20692075.
Rupenagunta, A., Somasundaram, I., Ravichandiram, V., Kausalya, J., Senthilnathan, B. (2011). Solid lipid nanoparticles- A versatile carrier system. J Pharm Res. 4(7): 20692075.
Schwarz, C., Mehnert, W., Lucks, J.S., Muller, R.H. (1994). Solid lipid nanoparticles (SLN) for controlled drug delivery I. Production, characterization and sterilization. J Control Release 30(1): 83-96.
DeSilva NS, Ofek I, Crouch EC. Interactions of surfactant protein D with fatty acids. Am J Respir Cell Mol Biol 2003;29: 757–70.
. Grabarek Z, Gergely J. Zero-length crosslinking procedure with the use of active esters. Anal Biochem 1990;185:131–5.
Giljohann DA, Seferos DS, Patel PC, et al. Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. Nano Lett 2007;7:3818–21.
Alyautdin R, Gothier D, Petrov V, et al. Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80coated poly (butyl cyanoacrylate) nanoparticles. Eur J Pharm Biopharm 1995;41:44–8.
Tung YT, Chen HL, Yen CC, et al. Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor. J Dairy Sci 2013; 96:2095–106.
Rahul Nair, K.S. Arun Kumar, K. Vishnu priya, M. sevukarajan, Recent Advances in solid liquid nanoparticle based drug delivery system, Journal of Biomedicine Science and research, Volume 3(2), 2011, PP-368-384.
Loira-Pastoriza C, Todoroff J, Vanbever R (2014) Delivery strategies for sustained drug release in the lungs. Adv Drug Deliv Rev 75:81–91.
K.h Ramteke, S. A. Joshi and S.N. Dhole, A review on solid liquid nanoparticles, IOSR journal of pharmacy, Vol-2, PP.34-44.
Cholifah S, Farina Kartinasari W, Indrayanto G. Simultaneous HPLC determination of levamisole hydrochloride and anhydrous niclosamide in veterinary powders, and its validation. J Liq Chromatogr Relat Technol. 2007;31:281–291.
Natarajan J, Baskaran M, Humtsoe LC, et al. Enhanced brain targeting efficacy of Olanzapine through solid lipid nanoparticles. Artif Cells Nanomed Biotechnol. 2017;45:364–371.
Griffiths PR, De Haseth JA. Fourier transform infrared spectrometry. Hoboken (NJ): John Wiley & Sons; 2007.
Fang J-Y, Fang C-L, Liu C-H, et al. Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm. 2008;70:633–640.
Zur M€uhlen A, Schwarz C, Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery-drug release and release mechanism. Eur J Pharm Biopharm. 1998;45:149–155.
Yang SC, Lu LF, Cai Y, et al. Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. J Control Release. 1999; 59:299–307.
Cecchelli R et al 1999 In vitro model for evaluating drug transport across the blood-brain barrier Adv. Drug Deliv. Rev. 36 165–78.
Lockman P R et al 2004 Nanoparticle surface charges alter blood-brain barrier integrity and permeability J. Drug Target 12 635–41.
Neves A R et al 2013 Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability Int. J. Nanomed. 8 177–87.
Hauser P S, Narayanaswami V and Ryan R O 2011 Apolipoprotein E: from lipid transport to neurobiology Prog. Lipid Res. 50 62–74.
Kaur I P et al 2008 Potential of solid lipid nanoparticles in brain targeting J. Control. Release 127 97–109.
Venishetty VK, Samala R, Komuravelli R, et al. b-Hydroxybutyric acid grafted solid lipid nanoparticles: a novel strategy to improve drug delivery to brain. Nanomedicine 2013; 9:388–97.
Anderson BF, Baker HM, Norris GE, et al. Structure of human lactoferrin crystallographic structure analysis and refinement at 2.8 A resolution. J Mol Biol 1989; 209:711.
Aisen P, Leibman A. Lactoferrin and transferrin: a comparative study. Biochim Biophys Acta 1972; 257:314–23.
Suzuki YA, Lopez V, Lonnerdal B. Mammalian lactoferrin receptors: structure and function. Cell Mol Life Sci 2005; 62:2560–75.
Huang RQ, Ke WL, Qu YH, et al. Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain. J Biomed Sci 2007; 14:121–8.
Ji B, Maeda J, Higuchi M, et al. Pharmacokinetics and brain uptake of lactoferrin in rats. Life Sci 2006; 78:851–5.
Hu K, Li J, Shen Y, et al. Lactoferrin-conjugated PEG–PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Control Release 2009; 134:55–61.
Kaur IP, Bhandari R, Bhandari S, Kakkar V. Potential of solid lipid nanoparticles in brain targeting. J Control Release 2008;127:97–109.
Trotta M, Debernardi F, Caputo O. Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int JPharm 2003;257:153–60.
DeSilva NS, Ofek I, Crouch EC. Interactions of surfactant protein D with fatty acids. Am J Respir Cell Mol Biol 2003;29:757–70.
Liu Z, Liu D, Wang L, et al. Docetaxel-loaded pluronic p123 polymeric micelles: in vitro and in vivo evaluation. Int J Mol Sci 2011;12:1684–96.
Shah R, Eldridge D, Palombo E, Harding I. Optimisation and stability assessment of solid lipid nanoparticles using particle size and zeta potential. J Phys Sci 2014;25:59–75.
Alyautdin RN, Petrov VE, Langer K, et al. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Pharm Res 1997; 14:325–8.
Alyautdin R, Gothier D, Petrov V, et al. Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly (butyl cyanoacrylate) nanoparticles. Eur J Pharm Biopharm 1995; 41:44–8.
Lazzari S, Moscatelli D, Codari F, et al. Colloidal stability of polymeric nanoparticles in biological fluids. J Nanopart Res 2012; 14:920–9.
Tung YT, Chen HL, Yen CC, et al. Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor. J Dairy Sci 2013; 96:2095–106.
Weiss CK, Kohnle MV, Landfester K, et al. The first step into the brain: uptake of NIO-PBCA nanoparticles by endothelial cells in vitro and in vivo, and direct evidence for their blood-brain barrier permeation. ChemMedChem 2008; 3:1395–403.
Garcia-Garcia E, Andrieux K, Gil S, Couvreur P. Colloidal carriers and blood brain barrier (BBB) translocation: a way to deliver drugsto the brain? Int J Pharm 2005; 298:274–92.
Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 2004; 56:1257–72.
Ekambaram P, Sathali AAH, Priyanka K. Solid lipid nanoparticles:
A review. Sci Rev Chem Commun 2012; 2:80–102.
Trotta M, Debernardi F, Caputo O. Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int J Pharm 2003; 257:153–60.
Avgoustakis K, Beletsi A, Panagi Z, et al. PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties. J Control Release 2002;79:123–35.
Suryasa, W. (2019). Historical Religion Dynamics: Phenomenon in Bali Island. Journal of Advanced Research in Dynamical and Control Systems, 11(6), 1679-1685.
Yarmukhamedova, N. F., Matkarimova, D. S., Bakieva, S. K., & Salomova, F. I. (2021). Features of the frequency of distribution of alleles and genotypes of polymorphisms of the gene Tnf-A (G-308a) in patients with rhinosinusitis and the assessment of their role in the development of this pathology. International Journal of Health & Medical Sciences, 4(1), 164-168. https://doi.org/10.31295/ijhms.v4n1.1671
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