The role of vitamin D supplementation in lifelong premature ejaculation
Keywords:
premature ejaculation, sexual stimulation, treatment, vitamin DAbstract
Background: Premature ejaculation (PE) is defined as persistent or recurrent ejaculation with minimal sexual stimulation before, upon, or shortly after penetration and before the person wishes it. Aim and objectives: The aim of this study was to measure the serum level of 25-hydroxyvitamin D (25 (OH) D) in lifelong premature ejaculation patients and evaluate the role of 25-hydroxyvitamin D (25 (OH) D) supplementation in these patients with low or in sufficient level of 25-hydroxyvitamin D (25 (OH) D). Subjects and methods: A total of 80 consecutive men who presented with lifelong PE. Results: The mean PEDT showed a statistically significant decrease after treatment. The mean IELT in the included cases before treatment with vitamin D is 31.14 ± 20.511 and the mean IELT in the included cases after treatment is 48.86 ± 26.432. The mean IELT showed a statistically significant increase after treatment. Conclusion: This study demonstrates that lower vitamin D levels are associated with the acquired PE. The result of our study showed that the role of serum vitamin D levels should be investigated in the etiology of acquired PE. Perhaps supplementation of vitamin D in men with acquired PE will ameliorate the sexual health of these patients.
Downloads
References
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5). American Psychiatric Association, WashingtonReturn to ref 7 in article, 2013.
Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J. The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking. Eur Urol. 2007; 51:816-23.
Godpodinoff ML. Premature ejaculation: clinical subgroups and etiology. J Sex Marital Ther. 1989; 15: 130-4.
Waldinger MD, Schweitzer DH. Changing paradigms from a historical DSM-III and DSM-IV view toward an evidencebased definition of premature ejaculation. Part I--validity of DSM-IV-TR. J Sex Med. 2006; 3: 682-92.
Serefoglu EC, McMahon CG, Waldinger MD, Althof SE, Shindel A, Adaikan G, et al. An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second international society for sexual medicine ad hoc committee for the definition of premature ejaculation. Sex Med. 2014; 2: 41-59.
Groves NJ, Kesby JP, Eyles DW, McGrath JJ, Mackay-Sim A, Burne TH. Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice. Behav Brain Res. 2013; 241: 120-31.
Hartmann U, Schedlowski M, Krüger TH. Cognitive and partner-related factors in rapid ejaculation: differences between dysfunctional and functional men. World J Urol. 2005; 23: 93-101.
Molinari C, Uberti F, Grossini E, Vacca G, Carda S, Invernizzi M, et al. 1α,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem. 2011; 27: 661-8.
Patrick RP, Ames BN. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014; 28: 2398-413.
Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf). 2010; 73: 243-8.
Abd El Aal AM, GamalEl Din SF, Rashed LA, Tawfik AERB, ElSheemy MS. Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study. Int Urol Nephrol. 2018;50:1975-80
Althof SE, McMahon CG, Waldinger MD, Serefoglu EC, Shindel AW, Adaikan PG, et al. An update of the International Society of Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation (PE). The journal of sexual medicine, 2014; 11(6): 1392-1422.
Corona G, Jannini EA, Mannucci E, Fisher AD, Lotti F, Petrone L, et al. Different testosterone levels are associated with ejaculatory dysfunction. The journal of sexual medicine, 2008; 5(8), 1991-1998.
Culha MG, Tuken M, Gonultas S, Cakir OO, Serefoglu EC. Frequency of etiological factors among patients with acquired premature ejaculation: prospective, observational, single-center study. International journal of impotence research, 2020; 32(3), 352-357.
Hewison M, Freeman L, Hughes SV, Evans KN, Bland R, Eliopoulos AG, et al. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. The Journal of Immunology, 2003; 170(11): 5382-5390.
D'Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, et al. Inhibition of IL-12 production by 1, 25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. The Journal of clinical investigation, 1998; 101(1): 252-262.
Din SFG, Rashed LA, ElSheemy M. S. Serum vitamin D level may be a novel potential risk factor for premature ejaculation: a comparative study. International urology and nephrology, 2018; 50(11), 1975-1980.
Horsanali MO, Caglayan A, Issi Y. Association between serum vitamin D levels and acquired premature ejaculation, 2021.
Suryasa, W., Sudipa, I. N., Puspani, I. A. M., & Netra, I. (2019). Towards a Change of Emotion in Translation of Kṛṣṇa Text. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 1221-1231.
Suwija, N., Suarta, M., Suparsa, N., Alit Geria, A.A.G., Suryasa, W. (2019). Balinese speech system towards speaker social behavior. Humanities & Social Sciences Reviews, 7(5), 32-40. https://doi.org/10.18510/hssr.2019.754
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.