Prognostic value of COMP a comparison with ACCP in rheumatoid arthritis patients in Iraq

Ali AbdulAmeer Oglah; Khalil Ismail AbidMohammed; Mohammed Hadi. Alosami

doi:10.53730/ijhs.v6nS6.10362

Authors

Ali AbdulAmeer Oglah Post graduate student in Department of Microbiology, College of Medicine, University of Baghdad
Khalil Ismail AbidMohammed Professor Dr. Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad
Mohammed Hadi. Alosami Professor Dr. of Rheumatology, College of Medicine, University of Baghdad

Keywords:

COMP, ACCP, rheumatoid arthritis patients, biomarkers, Iraq

Abstract

The study aimed To investigate prognostic ability of Cartilage oligomeric matrix protein (COMP)a comparison with Anti citrullinated peptide antibody (ACCP)and explore response to Methotrexate (MTX) , Etanercept and without treatment patients , with disease activity in rheumatoid arthritis Iraqi patients.Method of studywasCasecontrol. Measurement levels of biomarkersby ELISA.Results of ACCP and COMP levelsin RApatients highly significantly thanhealthy controlp< 0.001.highly significant ACCP and COMP levels in active diseasethan moderate and low activityp < 0.001 .Without treatments Patients ACCP and COMPlevels highly significant than onMTXor etanercept p<0.001, Statistically non-significant between on MTX andetanerceptp>0.05 .Significant positive correlation between ACCP and COMP(r =0.53,p<0.001) ACCP and CDAI (r =0.459,p < 0.001) COMP and CDAI(r =0.519, p<0.001) ACCP and COMP cutoff <)13.13 U / ml,< 0.21 ng / ml) Sensitivity (72 %,78 %) Specificity (98%,84%respectively).SuggestionCOMP has potential prognostic abilitya comparison with ACCPand to differentiation between RA patients andhealthyand predict severity of disease with response to MTX or etanercept.

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References

Albarzinji, N., Ismael, S. A.,&Albustany, D. (2022) . Association of rheumatoid arthritis and its severity with human leukocytic antigen-DRB1 alleles in Kurdish region in North of Iraq. BMC Rheumatology, 6(1),4–8. http://doi.org/10.1186/s41927-021-00229-9 .

Alwan, I.,&Ghali, K. H. (2021). The correlation between accp with developing, progression and activity of rheumatoid arthritis. Annals of the Romanian Society for Cell Biology, 25(4), 408–418.

Al -Yasiri, I. K., Al-Mousawi, J. K.,& Al-Mohana, A. M. (2014). Evaluation of Some Genetic Factors in Rheumatoid Arthritis patients in Iraq|Iraqi journal of biotechnology,13(2),66–74.https://jige.uobaghdad.edu.iq/index.php/IJB/article/view/282 .

Andersson, M. L., Svensson, B., Petersson, I. F., Hafström, I., Albertsson, K., Forslind, K., Heinegård, D., &Saxne, T. (2013). Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis. BMC musculoskeletal disorders, 14, 229. https://doi.org/10.1186/1471-2474-14-229.

Aref ,M.,&Ahmed, H.( 2015). Cartilage Oligomeric Matrix Protein as New Marker in Diagnosis of Rheumatoid arthritis . Modern Chemistry and Applications, 3(2),1-5. http://doi.org/10.4172/2329-6798.1000151 .

Bagherniya, M., Darand, M., Askari, G., Guest, P. C., Sathyapalan, T., &Sahebkar, A. (2021). The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials. Advances in experimental medicine and biology, 1291, 251–263. https://doi.org/10.1007/978-3-030-56153-6_15 .

Bullock, J., Rizvi, S., Saleh, A. M., Ahmed, S. S., Do, D. P., Ansari, R. A., & Ahmed, J. (2018). Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 27(6), 501–507. https://doi.org/10.1159/000493390.

Bugatti, S., Vitolo, B., Caporali, R., Montecucco, C., &Manzo, A. (2014). B cells in rheumatoid arthritis: from pathogenic players to disease biomarkers. BioMed research international, 2014, 681678. https://doi.org/10.1155/2014/681678

Chauhan, K.;Jandu, J. S.;Goyal, A.;Bansal, P.&Al-Dhahir,M.A. (2022). Rheumatoid Arthritis.In.StatPearls[Internet].TreasureIsland(FL):StatPearlsPublishing;2022. http://www.ncbi.nlm.nih.gov/books/NBK441999/.

Chiad, I. A.,Yossef, H. S., Al-Saidi, M. A.,& Abbas, M. A.(2015). Evaluation of Some Immunological Markers in the Rheumatoid Arthritis Patients. Iraqi Journal of Science, 56(3C), 2488–2493.https://www.iasj.net/iasj/pdf/03946ceb3f6b0809 .‬‬‬‬

El Defrawy, A. O., Gheita, T. A., Raslan, H. M., El Ansary, M. M., & El Awar, A. H. (2016). Serum and synovial cartilage oligomeric matrix protein levels in early and established rheumatoid arthritis. Oligomeres Knorpelmatrix protein in Serum und Synovialflüssigkeit – Konzentrationenbeifrüher und etablierterrheumatoiderArthritis. Zeitschrift fur Rheumatologie, 75(9), 917–923. https://doi.org/10.1007/s00393-015-1647-5.

Ge, C., Tong, D., Lönnblom, E., Liang, B., Cai, W., Fahlquist-Hagert, C., Li, T., Kastbom, A., Gjertsson, I., Dobritzsch, D., &Holmdahl, R. (2022). Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.), 74(6), 961–971. https://doi.org/10.1002/art.42072.

Han, R.(2020). Relationship Between Cartilage Oligomeric Matrix Protein Level and Helper T Cell 17/regulatory T Cell Balance in Patients With Rheumatoid Arthritis.PREPRINT (Version 1) . Research Square.https://doi.org/10.21203/rs.3.rs-46077/v1 .

Huang, J., Fu, X., Chen, X., Li, Z., Huang, Y., & Liang, C. (2021). Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis. Frontiers in immunology, 12, 686155. https://doi.org/10.3389/fimmu.2021.686155 .

Hussein, R. H.,MezherAl-Rayahi, I. A.,&Taha, K.( 2018). Rheumatoid factor isotypes in a sample of Iraqi rheumatoid arthritis patients. Journal of Global Pharma Technology, 10(8), 141–145.

Imari, M. J., Al, Al-Kaif, L. A., Hassan, F. G.,Jaafar, S. A., Al-Asady, H. A., Marwa, A. F.,Hameed, W. E.,&Trik, Z. (2021) . Evaluation Of Vitamin D Level In Serum Blood Of Rheumatoid Arthritis Patients In Babylon Province. Systematic Reviews in Pharmacy, 2(1), 268–271.

Jura-Półtorak, A., Szeremeta, A., Olczyk, K., Zoń-Giebel, A., &Komosińska-Vassev, K. (2021). Bone Metabolism and RANKL/OPG Ratio in Rheumatoid Arthritis Women Treated with TNF-α Inhibitors. Journal of clinical medicine, 10(13), 2905. https://doi.org/10.3390/jcm10132905 .

Kawashiri, S. Y., Kawakami, A., Ueki, Y., Imazato, T., Iwamoto, N., Fujikawa, K., et al. (2010). Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment: comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab. Joint bone spine, 77(5), 418–420. https://doi.org/10.1016/j.jbspin.2010.01.016 .

Khadim, R. M.,& Al-Fartusie, F. S.( 2021). Evaluation of Liver Function and Lipid profiles in Iraqi patients with Rheumatoid Arthritis. Journal of Physics: Conference Series, 1853,(012040). https://doi.org/10.1088/1742-6596/1853/1/012040.

Kwon, E. J., &Ju, J. H. (2021). Impact of Posttranslational Modification in Pathogenesis of Rheumatoid Arthritis: Focusing on Citrullination, Carbamylation, and Acetylation. International journal of molecular sciences, 22(19), 10576. https://doi.org/10.3390/ijms221910576.

Lamers-Karnebeek, F., Jacobs, J., Radstake, T., van Riel, P., & Jansen, T. L. (2019). Adalimumab drug and antidrug antibody levels do not predict flare risk after stopping adalimumab in RA patients with low disease activity. Rheumatology (Oxford, England), 58(3), 427–431. https://doi.org/10.1093/rheumatology/key292.

Liu, F., Wang, X., Zhang, X., Ren, C., &Xin, J. (2016). Role of Serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case-control study. The Journal of international medical research, 44(4), 940–949. https://doi.org/10.1177/0300060516639504 .

Maranini, B., Bortoluzzi, A., Silvagni, E., &Govoni, M. (2022). Focus on Sex and Gender: What We Need to Know in the Management of Rheumatoid Arthritis. Journal of personalized medicine, 12(3), 499. https://doi.org/10.3390/jpm12030499 .

Ma, S., Wang, C., Mao, X., & Hao, Y. (2019). B Cell Dysfunction Associated With Aging and Autoimmune Diseases. Frontiers in immunology, 10, 318. https://doi.org/10.3389/fimmu.2019.00318.

Marcucci, E., Bartoloni, E., Alunno, A., Leone, M. C., Cafaro, G., Luccioli, F., et al. (2018). Extra-articular rheumatoid arthritis. Reumatismo, 70(4), 212–224. https://doi.org/10.4081/reumatismo.2018.1106.

Machado-Alba, J. E., Ruiz, A. F.,& Morales, D. A. M. (2015). The epidemiology of rheumatoid arthritis in a cohort of Colombian patients. RevistaColombiana de Reumatologia, 22(3),148–152.

Ngo, S. T., Steyn, F. J., &McCombe, P. A. (2014). Gender differences in autoimmune disease. Frontiers in neuroendocrinology, 35(3), 347–369. https://doi.org/10.1016/j.yfrne.2014.04.004.

Posey, K. L., Coustry, F., & Hecht, J. T. (2018). Cartilage oligomeric matrix protein: COMPopathies and beyond. Matrix biology : journal of the International Society for Matrix Biology, 71-72, 161–173. https://doi.org/10.1016/j.matbio.2018.02.023 .

Qabulio, S.,Shaikh, F.,Mirza, A. I.,Shahid, M. A.,& Kumar, S.(2020) . Diagnostic Accuracy of Cartilage Oligomeric Matrix Protein (COMP), for Cartilage Damage in Rheumatoid Arthritis. Journal of Advances in Medicine and Medical Research,2456-8899, 62–69. https://doi.org/10.9734/jammr/2020/v32i1630631 .

Regueiro, C., Rodriguez-Rodriguez, L., Lopez-Mejias, R., Nuño, L., Triguero-Martinez, A., et al. (2020). A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis. Scientific reports, 10(1), 3355. https://doi.org/10.1038/s41598-020-60305-x.

Saghafi, M., Khodashahi, M., Saadati, N., Azarian, A., Rezaieyazdi, Z., Salehi, M., &Sahebari, M. (2017). Relationship between cartilage oligomeric matrix protein (COMP) and rheumatoid arthritis severity. Electronic physician, 9(12), 5940–5947. https://doi.org/10.19082/5940.

Sakthiswary, R., Rajalingam, S., Hussein, H., Sridharan, R., &Asrul, A. W. (2017). Cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and its correlation with sonographic knee cartilage thickness and disease activity. Clinical rheumatology, 36(12), 2683–2688. https://doi.org/10.1007/s10067-017-3817-0.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Smolen, J. S., Aletaha, D., Barton, A., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., & Yamamoto, K. (2018). Rheumatoid arthritis. Nature reviews. Disease primers, 4, 18001. https://doi.org/10.1038/nrdp.2018.1

Sweilam, M. A.,Attia, M. A., El-Saadany, H. M.,& Ibrahim, A. S. (2018) . Study the role of serum cartilage oligomericmatrix protein (COMP) in the diagnosis of rheumatoid arthritis patients. The Egyptian Journal of Hospital Medicine, 73(11), 8061–8073.

Tawfik, N. A., Abdul-mohymen, A. M., Ramadan, M. M.,& El-Nasser, A. M. (2019).Serum Cartilage Oligomeric Matrix Protein (COMP) a Biomarker of Rheumatoid Arthritis. Disease Activity and Knee Cartilage Thickness. International Journal of Internal Medicine, 8(2), 25–35.

Testa, D., Calvacchi, S., Petrelli, F., Giannini, D., Bilia, S., Alunno, A., &Puxeddu, I. (2021). One year in review 2021: pathogenesis of rheumatoid arthritis. Clinical and experimental rheumatology, 39(3), 445–452. https://doi.org/10.55563/clinexprheumatol/j1l5l3 .

Torrente-Segarra, V., Bergstra, S. A., Solomon-Escoto, K., Da Silva, J., Veale, D. J., Al-Emadi, S., & Huizinga, T. (2018). Is current smoking status and its relationship to anti-cyclic citrullinated peptide antibodies a predictor of worse response to biological therapies in rheumatoid arthritis patients?. Scandinavian journal of rheumatology, 47(5), 360–363. https://doi.org/10.1080/03009742.2017.1418423 .

Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202

Xu, Y., & Wu, Q. (2021). Prevalence Trend and Disparities in Rheumatoid Arthritis among US Adults, 2005-2018. Journal of clinical medicine, 10(15), 3289. https://doi.org/10.3390/jcm10153289 .

Yap, H. Y., Tee, S. Z., Wong, M. M., Chow, S. K., Peh, S. C., &Teow, S. Y. (2018). Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development. Cells, 7(10), 161. https://doi.org/10.3390/cells7100161.

Yu, C., Liu, C., Jiang, J., Li, H., Chen, J., Chen, T., & Zhan, X. (2020). Gender Differences in Rheumatoid Arthritis: Interleukin-4 Plays an Important Role. Journal of immunology research, 2020, 4121524. https://doi.org/10.1155/2020/4121524.