Formulation and evaluation of meloxicam loded liposomal gel as vesicular carriers for enhanced skin delivery

Priyanka Maurya; Ashutosh Kushwaha; Jai Narayan Mishra; Pooja Kumari; Saman Fatma

doi:10.53730/ijhs.v6nS5.10434

Authors

Priyanka Maurya
priyankamauryapharma@gmail.com
Assistant Professor, Kailash institute of pharmacy and management gida, Gorakhpur, India
Ashutosh Kushwaha Associate Professor, Kailash institute of pharmacy and management gida, Gorakhpur, India
Jai Narayan Mishra Director, Kailash institute of pharmacy and management gida, Gorakhpur, India
Pooja Kumari Research Scholer, Kailash institute of pharmacy and management gida, Gorakhpur, India
Saman Fatma Research Scholer, Kailash institute of pharmacy and management gida, Gorakhpur, India

Keywords:

Vesicle, meloxicam, in-vitro release, transmission electron microscopy, topical delivery

Abstract

Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked considerable interest because of their good activity for osteoarthritis. The aim of present study was to prepare and characterize liposomes of NSAIDS drug meloxicam, which may deliver these drugs to the target site more efficiently and also overcome the problem related with oral drug delivery of the drug. Methodology: In the present investigation efficiency of liposomes as a novel lipid for topical delivery of meloxicam has been evaluated. Liposomes were optimize by varying concentration of phospholipids cholesterol and ethanol. Liposomes formulation with soya lecithin, cholesterol and ethanol was optimized. Result: On characterization spherical, unilamellar vesicle with smooth surface were observed under Scanning electron microscopy and F4 formulation shows the best result. Conclusion: Suggested as liposomes as an efficient carriers for meloxicam topical drug delivery.

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