Formulation and evaluation of meloxicam loded liposomal gel as vesicular carriers for enhanced skin delivery
Keywords:
Vesicle, meloxicam, in-vitro release, transmission electron microscopy, topical deliveryAbstract
Background and objective: Applying liposomal gels in transdermal drug delivery system has evoked considerable interest because of their good activity for osteoarthritis. The aim of present study was to prepare and characterize liposomes of NSAIDS drug meloxicam, which may deliver these drugs to the target site more efficiently and also overcome the problem related with oral drug delivery of the drug. Methodology: In the present investigation efficiency of liposomes as a novel lipid for topical delivery of meloxicam has been evaluated. Liposomes were optimize by varying concentration of phospholipids cholesterol and ethanol. Liposomes formulation with soya lecithin, cholesterol and ethanol was optimized. Result: On characterization spherical, unilamellar vesicle with smooth surface were observed under Scanning electron microscopy and F4 formulation shows the best result. Conclusion: Suggested as liposomes as an efficient carriers for meloxicam topical drug delivery.
Downloads
References
A.D.BanghamandR.W.Horne(1964),Negativestainingofphospholipidsandtheirstructuremodificationbysurfaceactiveagentsasobservedintheelectronmicroscope,J.Mol.Biol.8,660–668
A.Sharma,U.S.Sharma,(1997),Liposomesindrugdelivery:progressandlimitations,Internationaljournalofpharmaceutics154(1997)123-140.
Available from www.pharmainfo.net/reviews/topical-drug- delivery-system-review. Shailesh, Topical preparations are used for the localized effects at the site of their application by virtue of drug penetration into the underlying layers of skin or mucous membranes, 2008, 1-13.
Bangham A.D., editor. The Liposome Letters. Academic Press; 1983.
Barner A. Review of clinical trials and benefit/risk ratio of Meloxicam. Scandinavian J ofRheumatology. 1996; 25(102):29-37.
Barry BW, Novel mechanism and devices to enable successful transdermal drug delivery, Eur J Pharm Sci, 2001; 14: 101-14.
Barry BW. Is transdermal drug delivery research still important today, Drug Discover Today. 2001; 6(19):967-71.
Biju SS, Sushama T, Mishra PR, Khar RK. Vesicular systems: An overview, Ind. J. Pharma Sci. 2006; 68(2):141-53.
Cevc G, Blume G, Schatzlein A, Gebauer D, Paul A. The skin pathway for systemic treatment patches and lipid based agent carriers, Advanced Drug Delivery Reviews. 1996; 18:349-78.
CJ Beukelman, MJ Hoekstra, K Reimer, S Mueller. Anti- inflammatory properties of a liposomal hydrogel with povidone- iodine for wound healing in vitro burns, International Journal of Pharmaceutics. 2008; 34(6):845-55.
D.A.White,C.BAnsell,J.N.HawthorneR.M.CDawson,Eds.1973,ThephospholipidscompositionofmammaliantissueIn:FormandFunctionofphospholipids.
D.D.Lasic,(1992),Liposomes,Am.Sci.80,20–31.
Dinesh D, Amit AR, Maria S, Awaroop RL, Mohd Hassan GD. Drug vehicle based approaches of penetration enhancement, International Journal of Pharmaceutical Sciences. 2009; 1(1):24-45.
Dusane Abhijit Ratilal, Gaikwad Priti D, Bankar Vidyadhar H, Pawar Sunil P. A Review on: Sustained Released Technology, IJRAP. 2011; 2(6):1701-08.
Dwijaya, A., & Atmaja, M. H. S. (2022). Clinical and imaging findings of klippel-trenaunay syndrome: A case report. International Journal of Health & Medical Sciences, 5(1), 145-149. https://doi.org/10.21744/ijhms.v5n1.1860
Ehrlich, P. The relations existing between chemical constitution, distribution and pharmacological action. In Ehrlich, P. (Ed.), Collected Studies on Immunity, Vol. 2, Wiley, New York, 1906, pp. 404 443.
Elsayed MM, Ossama YA, Naggar VF, Khalafallah NM. Deformable liposomes and ethosomes: Mechanism of enhanced skin delivery, International Journal of Pharmaceutics. 2006; 322:60-66.
Evans,D.F.,Wennerström,H.Thecolloidaldomain:wherephysics,chemistry,biologyandtechnologymeet,VCHPublishersInc.,1994
F.Comby,J.F.Lagorce,J.Buxeraud,andC.Raby.(1994).Antithyroidactionofketoconazole:in-vitro studiesandratin-vivostudies.JPharmPharmacol.46:50-53
Finney,J.L.,Soper,A.K.Chem.Soc.Rev.1994,1,1.
Ganesan MG, Weiner ND, Flynn GL, Ho NFH. Influence of liposomal drug entrapment on percutaneous absorption, International Journal of Pharmaceutics. 1984; 20:139-154.
Garcia MS, Sanchez- Pedreno C., Albero MI and Marti J. Spectrophotometric methods fordetermining Meloxicam in pharmaceuticals using batch and flow-injection procedures. European J of Pharmaceutical Sciences. 2000; 9(3):311-316.
H.A.H Rongen, A. Bult and W.P van Bennekom. J. Immuno. Methods, (1997) 204:105-133.
Hadgraft J. Passive enhancement strategies in topical and transdermal drug delivery, Int J Pharm. 1999; 184:1-6.
HimanshuA,SitasharanP,SinghaiAK:Liposomesasdrugcarriers.IJPLS2011,2(7):945–95
http://www.essentialdayspa.com/epidermis- c17. httm, Skin anatomy and physiology. (Online), 2009.
Jafar M and Ali S. Development and evaluation of Meloxicam solid dispersion loaded buccal patches. J of Applied Pharmaceutical Sciences. 2011; 01(03):77-82.
Jain NK. Advances in Controlled and Novel Drug delivery Systems. New Delhi: CBS Publisher and distributors, 2009, 278- 283.
Jr. F. Szoka and D. Papahadjopoulos. Proc. Natl. Acad. Sci. USA, (1978) 60:4194-4198.
KD Tripathi. Essentials of Medical Pharmacology, Jaypee Brothers Medical Publishers (P) LTD., 6th edition reprint. 2010; 757:763-764.
Kimball's Biology Pages, "Cell Membranes." Stryer S. Biochemistry, 1981, 213.
Lasic DD, Frederick PM, Stuart MCA, Barenholz Y, Mclntosh TJ. Gelation of liposomes interior-A novel method for drug encapsulation, International Journal of Pharmaceutics. 1992; 312:255-58.
Maghraby GM, Williams AC, Barry BW. Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes, International Journal of Pharmaceutics. 2004; 276:143-61.
Mezei M, Gulasekharam V. Liposomes - a selective drug delivery system for the topical route of administration, Life Sci. 1980; 26:1473-77.
Mohammed MN. In vitro release of hydrophilic and hydrophobic drugs from liposomal dispersions and gels, Act. Pharm. 2006; 56:311-24.
Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: Reviewing three decades of research, International Journal of Pharmaceutics. 2007; 332(1-2):1-16.
New, R.R.C., Preparation of liposomes. In: New, R.R.C.(Ed.), Lipsomes: a practical approach, IRL Press, Oxford,1990, pp. 33 104.
Peppas NA. Characterization of cross-linked structure of hydrogels, Med. Pharm. 1986; 1:27-56.
RogersandK.E.Anderson,Crit.Rev.Ther.DrugCarrierSyst.15,421(1998)
Schreier H, Bovwstra J. Liposomes and niosomes as topical drug carriers: dermal and transdermal drug delivery, Journal of Control Release. 1994; 30:1-15.
Schreier,R.Gonzalez-Rothib,andA.Stecenkoc,J.ControlRel.24,209(1993).
Seddon,J.M.Biochim.Biophys.Acta1990,1031,1.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Touitou E. Composition of applying active substance to
Touitou E. Composition of applying active substance to or through the skin, US Patent: 5,716,638, 1998.
Touitou E. Drug delivery across skin, Expert opinion on Biological Therapy. 2002; 2:723-33.
Usha Rai, Dinesh Chandra, Shaundarya Kumar. Ethosomal gel: a novel tool for topical drug delivery, International Journal of Universal Pharmacy and Life Sciences. 2013; 3(2):349-65.
Vermorken AJ, Hukkelhoven MW, Vermeesch AM, Goos CM, Wirtz P. The use of liposomes in the topical application of steroids, J. Pharm. Pharmacol. 1983; 36:334-36.
Vimal kumar Shahwal, Ajay Samnani, Dr. BK Dubey, Mithun Bhowmick. Ethosomes: An Overview, International Journal of Biomedical and Advance Research. 2011; 2(5):159-68.
Vyas S.P. & Khar R.K. “Targeted & controlled drug delivery: Novel carrier system”. CBS publishers and distributors, 2007.
Vyas SP, Khar RK. Targeted and controlled drug delivery: Novel carrier systems in liposomes. New Delhi: CBS Publisher and distributors, 2002, 196-197.
Wollenberg B, Lang S, Schmitt B, Kastenbauer E, Zeidler R. In vitro studies of liposome-mediated gene transfer into head and neck cancer cell lines, Eur. Arch. Otorhinolaryngol. 1997; 1(S130-2):254.
Xi Chen, Lihua Peng, Jianqing Gao. Novel topical drug delivery systems and their potential use in scars treatment, Asian Journal of Pharmaceutical Sciences, 2012; 7(3):155-67.
Yan Chen, Qingqing Wu, Zhenghai Zhang, Ling Yuan, Xuan Liu and Lei Zhou “Preparation of CurcuminLoaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics “ Molecules 2012, 17, 5972-5987.
Yuan Y, Chen X and Zhong D. Determination of meloxicam in human plasma by liquidchromatography-tandem mass spectroscopy following transdermal administration. J of Chromatography. 2007; 852:650-654.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.