Effect of zinc and clomiphene citrate on seminal fluid parameter in subfertile male

Hiba Sattar Jabbar; Hind Hadi Majeed; Rihab Abbas Ali; Maher Abbood Mukheef

doi:10.53730/ijhs.v6nS5.10451

Authors

Hiba Sattar Jabbar College of Medicine, Al-Muthanna University
Hind Hadi Majeed Jabir ibn hayyan medical university, college of medicine, department of human anatomy, Iraq
Rihab Abbas Ali University of Kerbala, College of medicine, department of anatomy
Maher Abbood Mukheef University of Kerbala, College of medicine, department of anatomy

Keywords:

Zinc, clomiphene citrate, testosterone, LH, FSH, spermatogenesis

Abstract

Subfertility is a universal, general problem of male and females factor. Zinc is one of the most important trace mineral, that plays an essential and necessary role in sperm generation and normal, physiological male reproduction. Pituitary Gonadotropins (FSH) and (LH) are basic for reproduction, FSH is a crucial role for sperm production and LH energize synthesis and production of testosterone Hormone. Currently, the most common therapy used in case of male subfertility clomiphene citrate, the study show significant increase in semen parameter and hormonal status after treatment with zinc 50 mg once/day and clomiphene citrate 50 mg twice/day for at least 2- 3 months. The aim of this research is. To evaluate the role of the zinc and clomiphene citrate on male subfertility case.

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References

Abed AA, Jarad A. Significance of Some Trace Elements in Semen of Infertile Men. Ibnosina Journal of Medicine and Biomedical Sciences, 2014;6(3):145-51.

Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative stress in male factor infertility: an update. Am J Reprod Immunol. 2008;59(1):2-11. Review. PubMed PMID: 18154591.

Ali H, Ahmed M, Baig M, et al. Relationship of zinc concentration in blood and seminal plasma with various semen parameters in infertile subjects. Pak J Med Sci. 2007:23111–4.

Batra, N., Nehru, B., & Bansal, M. P. (2004). Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status. British journal of nutrition, 91(3), 387-391.

Brandao-Neto, J., Madureira, G., Mendonca, B.B., Bloise, W. and Castro, A.V. Endocrine interaction between zinc and prolactin. An interpretive review. Biol. Trace Elem. Res.1995; 49:139-149.

Cheah Y, Yang W. Functions of essential nutrition for high quality spermatogenesis. BioScience. 2011;2(4):182-197. doi: 10.4236/abb.2011.24029.

Cousins RJ, Liuzzi JP, Lichten LA. Mammalian zinc transport, trafficking, and signals. J Biol Chem. 2006;281(34):24085-9. Epub 2006 Jun 22. Review. PubMed PMID:16793761.

Garg, H., & Kumar, R. (2016). An update on the role of medical treatment including antioxidant therapy in varicocele. Asian journal of andrology, 18(2), 222.

Hamada AJ, Esteves SC, Agarwal A. A comprehensive review of genetics and genetic testing in azoospermia. Clinics (Sao Paulo), 2013;68(1):39-60.

Heller CG, Rowley MH, Heller GV. Clomiphene citrate: a correlation of its effect on sperm concentration and morphology,total gonadotropins, ICSH, estrogen and testosterone excretion,and testicular cytology in normal men. J Clin Endocrinol Metab.1969;29(5):638-649.

Helo, S., Ellen, J., Mechlin, C., Feustel, P., Grossman, M., Ditkoff, E., & McCullough, A. (2015). A randomized prospective double‐blind comparison trial of clomiphene citrate and anastrozole in raising testosterone in hypogonadal infertile men. The journal of sexual medicine, 12(8), 1761-1769.

Henkel R, Bittner J, Weber R, et al. Relevance of zinc in human sperm flagella and its relation to motility. Fertil Steril. 1999;71:1138–43. [PubMed]

Henkel, R., Defosse, K., and Koyro, H. W. Estmate of oxygen consumption and intercellular zinc concentration of human spermatozoa in relation to motility: Asian, J. Anodrol.2003;5:3-8.

Katz, D. J., Nabulsi, O., Tal, R., & Mulhall, J. P. (2012). Outcomes of clomiphene citrate treatment in young hypogonadal men. BJU international, 110(4), 573-578.

Mellinger RC, Thompson RJ. The effect of clomiphene citrate in male infertility. Fertil Steril. 1966;17(1):94-103.

Ring, J. D., Lwin, A. A., & Köhler, T. S. (2016). Current medical management of endocrine-related male infertility. Asian journal of andrology, 18(3), 357–363.

Rowe, P. J., Comhaire, F., & World Health Organization. (1992). A double blind trial of clomiphene citrate for the treatment of idiopathic male infertility. International Journal of Andrology, 15(4), 299-307.

Ruwanpura SM, McLachlan RI, Meachem SJ. Hormonal regulation of male germ cell development. J Endocrinol. 2010;205:117–31.

Ruwanpura, S. M., McLachlan, R. I., & Meachem, S. J. (2010). Hormonal regulation of male germ cell development. The Journal of endocrinology, 205(2), 117-131.

Santi, L. K. S., Sudewi, A. A. R., Duarsa, D. P., & Lesmana, C. B. J. (2021). The effect of pregnancy massage on level of depression, anxiety and stress in pregnant women. International Journal of Health & Medical Sciences, 4(2), 220-225. https://doi.org/10.31295/ijhms.v4n2.1692

Showell, M. G., Mackenzie‐Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014). Antioxidants for male subfertility. Cochrane Database of Systematic Reviews, (12).

Soares, A. H., Horie, N. C., Chiang, L., Caramelli, B., Matheus, M. G., Campos, A. H., Marti, L. C., Rocha, F. A., Mancini, M. C., Costa, E., & Cercato, C. (2018). Effects of clomiphene citrate on male obesity-associated hypogonadism: a randomized, double-blind, placebo-controlled study. International journal of obesity (2005), 42(5), 953–963.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Taylor, F., & Levine, L. (2010). Clomiphene citrate and testosterone gel replacement therapy for male hypogonadism: efficacy and treatment cost. The journal of sexual medicine, 7(1), 269-276.

Tenover JS, Bremner WJ. The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men. J Androl 1991;12:258–63.

Vallee, B. L., & Falchuk, K. H. (1993). The biochemical basis of zinc physiology. Physiological reviews, 73(1), 79-118.

Wong WY, Mercus MW, Thomas CM, et al. Effect of folic acid and zinc sulfate on male factor subfertility; a double blind randomized placebo-controlled trial. Fertil Steril 2002;77(3):491-8. PubMed PMID:11872201.

Wong WY, Thomas CM, Merkus JM, et al. Male factor subfertility: possible causes and the impact of nutritional factors. Fertil Steril. 2000;73(3):435-42. Review. PubMed PMID: 10688992.

Wu, F. C. (2006). Hormonal approaches to male contraception: approaching reality. Molecular and cellular endocrinology, 250(1-2), 2-7.

Yunsang, C., & Wanxi, Y. (2011). Functions of essential nutrition for high quality spermatogenesis. Advances in Bioscience and Biotechnology, 2011.

Zegers‑Hochschild F, Adamson GD, de Mouzon J, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril 2009;92:1520‑4.

Zhang D, Gao J, Zhang K, Liu X, Li J. Effects of chronic cadmium poisoning on Zn, Cu, Fe, Ca, and metallothionein in liver and kidney of rats. Biological trace element research. 2012;149(1):57-63.