Estimation of serum calcium and phosphorus levels in male cataract patients
A case control study
Keywords:
cataract, G-protein, Na -K ATPase, calcium, phosphorusAbstract
Introduction: Cataract is vision-impairing disease marked by incremental, progressive lens thickening. The lens is composed of G-protein receptors that are linked to intracellular calcium release. Through the activation of calcium dependent proteases, elevated calcium levels can indicate metabolic disturbances and cell component disruption. The Na+-K+ ATPase pump’s activity in maintaining a low cytoplasm Ca2+ concentration increases calcium levels significantly, causing rapid lens fibre breakdown, uncontrolled protein breakdown, cell swelling, and opacification. Phosphorus is involved in membrane permeability of the lens. The objective of the present study was to estimate and compare the serum calcium and phosphorus levels in males diagnosed with cataract and without cataract. Methodology: A total of 110 subjects were studied, of which 55 were diagnosed cataract patients and 55 were controls with no signs of cataract on ophthalmologic examination. Serum calcium and phosphorus were estimated. The obtained data was analysed statistically. Independent t test was used to associate the parameters. Results: In our study we found significantly increased levels of serum calcium in cataract patients (p<0.05) as compared to controls. Serum phosphorus concentration in cataract patients (p<0.05) was significantly increased as compared to controls.
Downloads
References
Katta AV, Suryakar AN, Katkam RV, Shaikh K, Ghodake SR. Glycation of lens crystalline protein in the pathogenesis of various forms of cataract.
Khurana AK. Comprehensive ophthalmology. Diseases of lens. 7th edition. Jaypee Brothers Medical Publishers; 2019 Jun 30. 184-196.
Li H. Free radicals and cataract. Spring. 2003;222(77):1-23.
Prajna NV. Peyman's Principles & Practice of Ophthalmology: Volume01 chapter3 occular biochemistry JP Medical Ltd; 2019 Apr 30: 78.
Hightower KR. Cytotoxic effects of internal calcium on lens physiology: a review. Current eye research. 1985 Jan 1;4(4):453-9.
Duindam JJ, Vrensen GF, Otto C, Greve J. Cholesterol, phospholipid, and protein changes in focal opacities in the human eye lens. Investigative ophthalmology & visual science. 1998 Jan 1; 39(1):94-103.
Duncan G, Webb SF, Dawson AP, Bootman MD, Elliott AJ. Calcium regulation in tissue-cultured human and bovine lens epithelial cells. Investigative ophthalmology & visual science. 1993 Sep 1;34(10):2835-42.
Stern J, Lewis WH. The colorimetric estimation of calcium in serum with O-cresolphthalein complexone. Clinica Chimica Acta. 1957 Dec 1; 2(6):576-80.
Fiske CH, Subbarow Y. The colorimetric determination of phosphorus. J. biol. Chem. 1925 Dec 1; 66(2):375-400.
Italian-American Cataract Study Group. Risk factors for age-related cortical, nuclear, and posterior subcapsular cataracts. American Journal of Epidemiology. 1991 Mar 15;133(6):541-53.
Consul BN, Charan SS, Sharma RG. A study of inter relationship between the lenticular and blood calcium contents in various types of human cataractous lenses. Indian Journal of Ophthalmology. 1970 Jul 1;18(3):99.
Clark JI, Mengel L, Bagg A, Benedek GB. Cortical opacity, calcium concentration and fiber membrane structure in the calf lens. Experimental eye research. 1980 Oct 1;31(4):399-410.
Aniqa M, Roquyya G, Tayyaba Gul M, Muhammad K, Rabail A. Senile cataract patients; serum electrolytes and calcium.
Altouhami RO, Ali AE. Assessment of serum zinc, calcium and magnesium among Sudanese patients with senile cataract in Khartoum State-Sudan. Ophthalmol Case Rep. 2018; 2 (2): 1-3. Ophthalmol Case Rep 2018 Volume 2 Issue.;2.
Mirsamadi M, Nourmohammadi I. Correlation of human age-related cataract with some blood biochemistry constituents. Ophthalmic research. 2003;35(6):329-34.
Deokar S, Rai P, Rai A, Sundharan S, Bakshi A. Serum calcium and phosphorus levels: a marker of disease activity in senile cataract patients. International Journal of Advances in Medicine. 2018;5:371-4.
Kim CJ, Choi SK. Analysis of aqueous humour calcium and phosphate from cataract eyes with and without diabetes mellitus. Korean journal of ophthalmology: KJO. 2007 Jun;21(2):90.
Tang D, Borchman D, Yappert MC, Vrensen GF, Rasi V. Influence of age, diabetes, and cataract on calcium, lipid-calcium, and protein-calcium relationships in human lenses. Investigative ophthalmology & visual science. 2003 May 1;44(5):2059-66.
Klein BE, Klein R, Ritter LL. Is there evidence of an estrogen effect on age-related lens opacities?: The Beaver Dam Eye Study. Archives of Ophthalmology. 1994 Jan 1;112(1):85-91.
del Castillo JM, del Rio T, Garcia-Sanchez J. Effects of estrogen use on lens transmittance in postmenopausal women. Ophthalmology. 1997 Jun 1;104(6):970-3.
Erdem, S. Diseases associated with age-related cataract: a health-board-based retrospective study focusing on common physiopathological mechanisms. J Public Health (Berl.) 29, 163–167 (2021). https://doi.org/10.1007/s10389-019-01113-0
Afshari NA, Afshari MA, Foster CS. Inflammatory conditions of the eye associated with rheumatic diseases. Curr Rheumatol Rep. 2001 Oct;3(5):453-8. doi: 10.1007/s11926-996-0017-3. PMID: 11564378
Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
