Predictive correlation of adverse clinical outcomes with thrombocytopenia in dengue fever: A single center experience

Anurag Singh Chauhan; Manisha Thakur; Kishori Lal Meena; Kavita Yadav; Ghanshyam Gahlot

doi:10.53730/ijhs.v6nS5.10514

Authors

Anurag Singh Chauhan Senior Advisor (Medicine) from Indian Navy, INHS Kalyani, Gandhigram, Tamil Nadu, India
Manisha Thakur Classified Specialist (Paediatric) from Indian Navy, INHS Kalyani, Gandhigram, Tamil Nadu, India
Kishori Lal Meena Assistant Professor, Department of Biochemistry, Govt. Medical College and Associated Group of Hospitals, Barmer, India
Kavita Yadav
kavita2529@gmail.com
Associate Professor, Department of Physiology, S.K. Govt. Medical College and Hospitals, Sikar, India
Ghanshyam Gahlot Senior Demonstrator, Department of Biochemistry, Govt. Medical College and Associated Group of Hospitals, Barmer, India

Keywords:

thrombocytopenia, dengue fever, mortality

Abstract

Background: Dengue fever is the most widely distributed viral infection in the world with more than 100 million people affected. In this study we attempt to study the co-relation between the nadir of the plateletcount and the onset of warning signs (persistent pain abdomen and vomiting, mucocutaneous bleed or clinical fluid accumulations). A positive co-relation in between these two elements could help predict onset of shock and third spacing and facilitate prognostication and early intervention. Methods: We studied 82 patients with a diagnosis of dengue fever, the basis of which was clinical signs and symptoms with a positive NS1 antigen test. The nadir of thrombocytopenia and rise in transaminases were studied along with onset of various warning signs. Results: The nadir of thrombocytopenia correlates with onset of warning signs such as clinical fluid accumulation (two tailed P value <0.002) and mucosal bleed (two tailed P value <0.001). However, the rising value of transaminases does not co-relate statistically with onset of warning signs in Dengue fever. Conclusions: The age of patients ranged from 18 to 60 with 23 out of 83 (27.7%) being in the 30-40 years age group.

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