Assessment of outcome of regenerative endodontics for treatment of periapical lesions
Keywords:
allogenic umbilical cord, stem cells, periapical pathologyAbstract
Background: Three key elements are essential for performing REPs: stem cells, scaffolds, and activators. The present study was conducted to assess outcome of regenerative endodontics for treatment of periapical lesions. Materials & Methods: 40 patients with mature incisors, canines, or mandibular premolars showing pulp necrosis and apical periodontitis were divided into group I (REP) and conventional root canal treatment (ENDO) group II. Calcium hydroxide medication was used, and the cavity was sealed. 3 weeks later, patients were treated following their assigned protocol of ENDO or REP. Clinical follow-up examinations were performed at 6 months and 12 months. Results: At 6 months, success was seen in 20 teeth in group I and 18 in group II and failure in 2 in group II. At 12 months, success was seen in 20 in each group. The mean height (mm) at 6 months was 2.5 and 2.8 in group I and II, at 12 months was 1.6 and 1.9. Anterior-posterior dimension at 6 months was 2.6 and 2.7 and at 12 months was 1.8 and 2.2. Mesiodistal dimension at 6 months was 3.1 and 2.5 and at 12 months was 1.8 and 2.1 in group I and II respectively.
Downloads
References
Arora, A.; Bhesania, D.; Kapoor, S. A 5 years’ follow-up of root anatomy-based maturogenesis achieved in infected immature molars using regenerative techniques—A case series. J. Conserv. Dent. 2020, 23, 422–427.
Arslan, H.; ¸Sahin, Y.; Topçuo ˘glu, H.S. Histologic Evaluation of Regenerated Tissues in the Pulp Spaces of Teeth with Mature Roots at the Time of the Regenerative Endodontic Procedures. J. Endod. 2019, 45, 1384–1389.
Arslan, H.; Ahmed, H.M.A.; ¸Sahin, Y. Regenerative Endodontic Procedures in Necrotic Mature Teeth with Periapical Radiolucencies: A Preliminary Randomized Clinical Study. J. Endod. 2019, 45, 863–872.
Brizuela, C.; Meza, G.; Urrejola, D.; Quezada, M.A.; Concha, G.; RamÕrez, V.; Angelopoulos, I.; Cadiz, M.I.; Tapia-Limonchi, R.; Khoury, M. Cell-Based Regenerative Endodontics for Treatment of Periapical Lesions: A Randomized, Controlled Phase I/II Clinical Trial. Journal of Dental Research 2020;002203452091324.
Cordero, C.B.; Santander, G.M.; González, D.U. Allogeneic Cellular Therapy in a Mature Tooth with Apical Periodontitis and Accidental Root Perforation: A Case Report. J. Endod. 2020, 46, 1920–1927.e1
Djuraev, A. M., Alpisbaev, K. S., & Tapilov, E. A. (2021). The choice of surgical tactics for the treatment of children with destructive pathological dislocation of the hip after hematogenous osteomyelitis. International Journal of Health & Medical Sciences, 5(1), 15-20. https://doi.org/10.21744/ijhms.v5n1.1813
Garrido-Parada, S Castelo-Baz, P., Feijoo-Pato, N.; Gaviño-Orduña, J.; Martín-Biedma, B. Endodontic Regenerative Procedures in Necrotic Adult Teeth. Appl. Sci. 2022, 12, 4212.
Kandemir, G.; Güneri, P.; Çalı¸skan, M.K. Regenerative Endodontic Therapy with Platelet Rich Fibrin: Case Series. J. Clin. Pediatr. Dent. 2020, 44, 15–19.
Nagas, E.; Uyanik, M.O.; Cehreli, Z.C. Revitalization of necrotic mature permanent incisors with apical periodontitis: A case report. Restor. Dent. Endod. 2018, 43, e31.
Nagaveni, N.B.; Poornima, P.; Mathew, M.G. A Comparative Evaluation of Revascularization Done in Traumatized Immature, Necrotic Anterior Teeth with and without Platelet-rich Fibrin: A Case Report. Int. J. Clin. Pediatr. Dent. 2020, 13, 98–102.
Nangia D, Saini A, Sharma S, Kumar V, Chawla A, Perumal V, Logani A. Treatment outcome of regenerative endodontic procedures in mature permanent teeth compared to nonsurgical endodontic treatment: A systematic review and meta-analysis. Journal of Conservative Dentistry: JCD. 2021 Nov;24(6):530.
Nivedhitha, M.S.; Jacob, B.; Ranganath, A. Concentrated Growth Factor: A Novel Platelet Concentrate for Revascularization of Immature Permanent Teeth-A Report of Two Cases. Case Rep. Dent. 2020, 2020, 1329145.
Prasad, M.G.S.; Ramakrishna, J.; Babu, D.N. Allogeneic stem cells derived from human exfoliated deciduous teeth (SHED) for the management of periapical lesions in permanent teeth: Two case reports of a novel biologic alternative treatment. J. Dent. Res. Dent. Clin. Dent. Prospect. 2017, 11, 117–122.
Saoud, T.M.; Mistry, S.; Kahler, B. Regenerative Endodontic Procedures for Traumatized Teeth after Horizontal Root Fracture, Avulsion, and Perforating Root Resorption. J. Endod. 2016, 42, 1476–1482.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.