The associations between serum dihydrotestosterone levels, lipid parameters & anthropometric measurements in male patients with type 2 diabetes mellitus
Keywords:
dihydrotestosterone, type 2 diabetes mellitus, lipid profile, wasit hip ratio, BMIAbstract
Background: Male fertility is affected by the metabolic and hormonal dysregulation brought on by Diabetes Mellitus, a metabolic illness, particularly in the hypothalamus-pituitary testicular axis. However, there is little proof that endocrinopathy causes diabetic men's infertility and low testosterone levels. It is well established that Type 2 Diabetes causes dyslipidemia & obesity by lowering serum testosterone levels. However, there isn't much research on DHT, the most potent androgen, and its relationship to male lipid profiles. Methods: The study was carried out at Teerthanker Mahaveer Medical College and Research Centre, Moradabad, in the Department of Physiology and Medicine & Department of Physiology Santosh Medical College, Ghaziabad. A total of 210 samples—105 from type 2 diabetics and 105 from controls—were included in the study. Using conventional biochemical techniques, Lipid parameters [HDL, LDL, VLDL &TC], serum DHT, Data analysis was done with SPSS 26. [ trial version]. Results: The levels of serum dihydrotestosterone were significantly lower in diabetic cases than in healthy controls [439.26 ± 257.87pg/ml vs 230.66 ± 182.02pg/ml, p=0.001]. 90 percent of Type 2 diabetics were found to have subnormal levels, as opposed to just 10 percent of controls.
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