Impact of diabetes mellitus on ocular pseudo exfoliation syndrome and open angle glaucoma in Iraqi patients
Keywords:
pseudo exfoliation PEX, open angle glaucoma OAG, pseudo exfoliation open angle glaucoma (XFG), Type 2 diabetes mellitus(T2DM), intraocular pressure (IOP)Abstract
Background: Diabetes mellitus cause wide spectrum of ophthalmic complications including cataract and glaucoma. Pseudo exfoliation (PEX), although it is an age related,can lead to the development of glaucoma (secondary open angle glaucoma), but the exact mechanism is not well understood, and was described to be associated with different causes like ethnic, genetic, environmental and other organic causes, and a controversy exist about its relation with diabetes mellitus. Aim: To the impact or the association of state of diabetes mellitus with psudoexfoliation (PEX) and open angle glaucoma (OAG). Methodology: This is an observational descriptive cross sectional, case control study included; 214 type 2 diabetes mellitus patients aged 45–72 years, and 214 as control non diabetic persons attending The Specialized Center for Endocrinology and Diabetes – Baghdad, the capital of Iraq between May2020– Jan 2021. Results: Of the 214 diabetic patients 66 (30.84%) were having PEX, versus 12(5.6%), in the control group, with p value < 0,001, and of these 66 patients 44(67.5%) were females and 22 (32.5%) males with ratio 2:1, p value non-significant. Mean age for PEX group was 40.36 ± 4.2 SD, versus 52.43±3.2 SD in non-PEX, with significant p value.
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Henrik Forsius, Eva Forsman, Johan Fellman and AldurW. Eriksson, Exfoliation syndrome:Frequency, gender distribution and association with climatically induced alterations of the cornea and conjunctiva,; Acta Ophthalmol Scand (Suppl) : 202.
Jeng SM,Karger RA,Hodge DO,Burke JP,Johnson DH,Good MS, The risk of glaucoma in pseudoexfoliation syndrome. Journal of glaucoma. 2007 Jan.
C Schweitzer, Pseudoexfoliation syndrome and pseudoexfoliation glaucoma , J Fr Ophtalmol . 2018 Jan;41(1):78-90.
Pasutto F., Zenkel M., Hoja U., Berner D., Uebe S., Ferrazzi F., Schödel J., Liravi P., Ozaki M., Paoli D., et al. Pseudoexfoliation syndrome-associated genetic variants affect transcription factor binding and alternative splicing of LOXL1. Nat. Commun. 2017;8:15466.
Ritch R. Systemic Associations of Exfoliation Syndrome. Asia Pac J Ophthalmol (Phila) 2016 Jan-Feb;5(1):45–50.
Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2021, Diabetes Care 2021;44(Supplement_1):S15–S33.
Mihaela Sollosy , Incidence of the uveal pseudoexfoliation syndrome in patients with diabetes mellitus ,Oftalmologia 2004, 48 (1): 76-80 .
Martynas Spečkauskas, Abdonas Tamošiūnas, Vytautas Jašinskas Association of ocular pseudoexfoliation syndrome with ischaemic heart disease, arterial hypertension and diabetes mellitus , Acta Ophthalmologica 2012, 90 (6).
J B Jonas , A E Gründler,Prevalence of diabetes mellitus and arterial hypertension in primary and secondary open-angle glaucomas, Graefes Arch Clin Exp Ophthalmol. 1998 Mar;236(3):202-6.
Mukharram M Bikbov, Rinat M Zainullin, Timur R Gilmanshin, Gyulli M Kazakbaeva, Dilya F Yakupova, Ildar F Nuriev, Artur F Zaynetdinov, Timur A Khalimov, Songhomitra Panda-Jonas, Yulia V Uzianbaeva, Ellina M Rakhimova, Iulia A Rusakova, Venera F Salavatova, Inga I Arslangareeva, Guzel M Bikbova, Nikolay A Nikitin, Jost B Jonas. Prevalence and Associated Factors of Pseudoexfoliation in a Russian Population: The Ural Eye and Medical Study, American Journal of Ophthalmology 2020, 210: 158-166.
11.K G Psilas, M J Stefaniotou, M B Aspiotis Pseudoexfoliation syndrome and diabetes mellitus, Acta Ophthalmologica 1991, 69 (5): 664-6.
Qi Sheng You, Liang Xu, Ya Xing Wang, Hua Yang, Ke Ma, Jian Jun Li, Li Zhang, Jost B Jonas, Pseudo exfoliation: normative data and associations: The Beijing eye study 2011, Ophthalmology 2013, 120 (8): 1551-8.
R Allingham, M Loftsdottir, M S Gottfredsdottir, E Thorgeirsson, F Jonasson, T Sverisson, W G Hodge, K F Damji, E Stefánsson Pseudoexfoliation syndrome in Icelandic families, British Journal of Ophthalmology 2001, 85 (6): 702-7.
K G Psilas, M J Stefaniotou, M B Aspiotis, Pseudoexfoliation syndrome and diabetes mellitus , Acta Ophthalmologica 1991, 69 (5): 664-6 ,1776424.
Ali A Taqi, University of Sulaimaniya, Iraq, A clinical survey of pseudo exfoliation syndrome in Sulaimaniya city- Kurdistan Iraq, 3rd International Conference on Eye and Vision, August 21-23, 2017 | Toronto, Canada.
Hani Mahmood Mansoor & Hayder Adnan Fawzi, Clinical Survey of Pseudoexfoliation Syndrome, Global Journal of Health Science; Vol. 11, No. 5; 2019,ISSN 1916-9736 E-ISSN 1916-9744,Published by Canadian Center of Science and Education.
Konstas, Anastasios , Ringvold, Amund ,Epidemiology of Exfoliation Syndrome, Journal of Glaucoma: July 2018 – Vol. 27 - Issue - p S4-S11.
Amund Ringvold, Epidemiology of the pseudo-exfoliation syndrome, Acta Ophthalmol Scand . 1999 Aug;77(4):371-375.
Tiliksew Teshome , Kefyalew Regassa, Prevalence of pseudoexfoliation syndrome in Ethiopian patients scheduled for cataract surgery, Acta Ophthalmol Scand,Volume82, Issue3p1,June 2004 ,Pages 254-258.
Konstas AG, Allan D. Pseudoexfoliation glaucoma in Greece. Eye. 1989;3:747–753.
Ekström C. Incidence of open-angle glaucoma in central Sweden. Acta Ophthalmol. 2008;86:747–754.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Arnarsson AM. Epidemiology of exfoliation syndrome in the Reykjavik Eye Study. Acta Ophthalmol. 2009;87(thesis 3):1–17.
Forsius H, Forsman E, Fellman J, et al. Exfoliation syndrome: frequency, gender distribution and association with climatically induced alterations of the cornea and conjunctiva. Acta Ophthalmol.2002;80:478–484.
Vesti E, Kivelä T. Exfoliation syndrome and exfoliation glaucoma. Prog Ret Eye Res. 2000;19:345–368.
Saraswati, P. A. I. ., Gunawan, I. M. K., & Budiyasa, D. G. A. (2021). Overview of glomerulus filtration in type 2 of diabetes mellitus at Sanjiwani Gianyar hospital year of 2018-2019. International Journal of Health & Medical Sciences, 4(1), 50-55. https://doi.org/10.31295/ijhms.v4n1.726
Ritch R. Exfoliation syndrome. Curr Opin Ophthalmol. 2001;12:124–130.
Ringvold A, Blika S, Elsas T, et al. The Middle-Norway eye-screening study. II. Prevalence of simple and capsular glaucoma. Acta Ophthalmol. 1991;69:273–280.
Konstas AG, Allan D. Pseudoexfoliation glaucoma in Greece. Eye. 1989;3:747–753.
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