Evaluation of 25-hydroxy vitamin d3 levels in patients with small uterine myomas
Keywords:
25-OH-D3, fibroids, myomas, supplementation, vitamin DAbstract
Background; Uterine fibroid are the most frequent benign pelvic tumors between women in reproductive period group that has multifactorial pathogenesis. Modern ideas of uterine fibroid pathogenesis have included vitamin D as a vital component. Aim and objectives; was to study the link between 25-hydroxy vitamin D3 levels in cases having small uterine myomas. Subjects and methods; This is a case-control study, was conducted at the Gynecology and Obstetrics department outpatient clinic at Al Zahraa University Hospitals, on 60 women divided into two groups: (Study group); included Thirty cases having fibroid uterus, (Control group); included Thirty women who had no fibroid uterus. Result; When compared to controls, vitamin D3 levels in cases were considerably lower. Conclusion; Vitamin D looks to be a promising and valuable anti-UF treatment. More large, well-designed randomized clinical trials are needed to look into the effectiveness of vitamin D in females with UFs of all ethnicities, especially those of color who are at higher risk of vitamin D deficiency. As a result, vitamin D may become a viable treatment choice for UF, with the added benefit of its pleiotropic impact.
Downloads
References
Singh, V., Barik, A., & Imam, N. Vitamin D 3 Level in Women with Uterine Fibroid: An Observational Study in Eastern Indian Population. The Journal of Obstetrics and Gynecology of India. 2019; 69(2), 161-165.
Holick, M. F. Vitamin D: its role in cancer prevention and treatment. Progress in biophysics and molecular biology. 2006; 92(1), 49-59.
Ciebiera, M., Włodarczyk, M., Ciebiera, M., Zaręba, K., Łukaszuk, K., & Jakiel, G. Vitamin D and uterine fibroids—review of the literature and novel concepts. International journal of molecular sciences. 2018; 19(7), 2051- 2068.
Ciebiera, M., Ali, M., Zgliczyńska, M., Skrzypczak, M., & Al-Hendy, A. Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance. International Journal of Molecular Sciences. 2020; 21(15), 5528-5552.
Donnez, J., & Dolmans, M. M. Uterine fibroid management: from the present to the future. Human Reproduction Update. 2016; 22(6), 665-686.
Rubisz, P., Ciebiera, M., Hirnle, L., Zgliczynska, M., Lozinski, T., Dziegiel, P., et al. The usefulness of immunohistochemistry in the differential diagnosis of lesions originating from the myometrium. Int. J. Mol. Sci. 2019; 20, 1136.
Stewart, E.A., Laughlin-Tommaso, S.K., Catherino, W. H., Lalitkumar, S., Gupta, D., Vollenhoven, B. Uterine fibroids. Nat. Rev. Dis. Primers. 2016; 2, 16043.
Stewart, E.A., Cookson, C.L., Gandolfo, R.A., Schulze-Rath, R. Epidemiology of uterine fibroids: A systematic review. BJOG. 2017; 124, 1501–1512.
Munusamy, M. M., Sheelaa, W. G., Lakshmi, V. P., Clinical presentation and prevalence of uterine fibroids: a 3-year study in 3-decade rural South Indian women. Int J Reprod Contracept Obstet Gynecol. 2017; 6:5596–601.
Srivastava, P., Gupta, H. P., Singhi, S., Khanduri, S., & Rathore, B. Evaluation of 25-hydroxy vitamin D3 levels in patients with a fibroid uterus. Journal of Obstetrics and Gynaecology. 2020; 40(5), 710-714.
Paffoni, A., Somigliana, E., Vigano, P., Vitamin D status in women with uterine leiomyomas. J Clin Endocrinol Metab. 2013; 98 (8): E1374–8.
Mohammadi, R., Tabrizi, R., Hessami, K., Ashari, H., Nowrouzi-Sohrabi, P., Hosseini-Bensenjan, M., et al. Correlation of low serum vitamin-D with uterine leiomyoma: A systematic review and meta-analysis. Reprod. Biol. Endocrinol. 2020; 18, 1–8.
Baird, D. D, Hill, M. C., Schectman, J. M., et al. Vitamin D and the risk of uterine fibroids. Epidemiology. 2013; 24: 447–53.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
