A comprehensive ethnopharmacological review on onion, garlic and ginger

https://doi.org/10.53730/ijhs.v6nS5.10830

Authors

  • Sanjita Das HOD and Assistant Professor, Noida Institute of Engineering & Technology (Pharmacy Institute)
  • Km. Renu Singh Master of Pharmacy, Noida Institute of Engineering & Technology (Pharmacy Institute)
  • Shivani Shrivastava Master of Pharmacy, Noida Institute of Engineering & Technology (Pharmacy Institute)
  • Irfan Khan Master of Pharmacy, Noida Institute of Engineering & Technology (Pharmacy Institute)
  • Shruti Dhasmana Master of Pharmacy, Noida Institute of Engineering & Technology (Pharmacy Institute)

Keywords:

Ginger, antioxidants, garlic, onion, therapeutic activity, bioactive constituents

Abstract

It is a therapeutic aspect of medicinal herbs present in the kitchen for immediate treatment. Herbal plants can treat various diseases and ailments. It would be of great benefit in medical and surgical treatment. The promotion of the health system is easier, with medicinal plants than synthetic drugs. This study reviewed the medicinal properties of some of important spices generally found in every kitchen; onion, ginger and garlic. These commonly used spices are important in medicine due to the presence of many bioactive constituents and nutrients. Some chemical constituents of these medicinal plants have been reported in various literatures to contribute to the prevention and treatment of various diseases and ailments. In literatures, some of the documented properties of onion, garlic and ginger include antioxidant, anti-inflammatory, rheumatologic, blood circulation and anticramp, anti-ulcer, anticholinergic, analgesic, antimicrobial, anti-stress, anti-cancer, immunity booster, anti-diabetic, regulation of blood pressure and treatment of cardiovascular diseases. The use of these medicinal plant materials as potent neutraceuticals will aid the promotion of human health system in socioeconomic aspects.

Downloads

Download data is not yet available.

References

Adetumbi, M. A., & Lau, B. H. (1986). Inhibition of in vitro germination and spherulation of Coccidioides immitis by Allium sativum. Current Microbiology, 13(2), 73-76.

Afzal, Μ., Al-Hadidi, D., Menon, M., Pesek, J., & Dhami, M. S. I. (2001). Ginger: an ethnomedical, chemical and pharmacological review. Drug metabolism and drug interactions, 18(3-4), 159-190.

Ahmed, R. S., Suke, S. G., Seth, V., Chakraborti, A., Tripathi, A. K., & Banerjee, B. D. (2008). Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane‐induced oxidative stress in rats. Phytotherapy Research, 22(7), 902-906.

Ajith, T. A., Aswathy, M. S., & Hema, U. (2008). Protective effect of Zingiber officinale roscoe against anticancer drug doxorubicin-induced acute nephrotoxicity. Food and chemical toxicology, 46(9), 3178-3181.

Ankri, S., Miron, T., Rabinkov, A., Wilchek, M., & Mirelman, D. (1997). Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrobial agents and chemotherapy, 41(10), 2286-2288.

Benavides, G. A., Squadrito, G. L., Mills, R. W., Patel, H. D., Isbell, T. S., Patel, R. P., ... & Kraus, D. W. (2007). Hydrogen sulfide mediates the vasoactivity of garlic. Proceedings of the National Academy of Sciences, 104(46), 17977-17982.

Bhushan, S. (1984). Effect of oral administration of raw onion on glucose tolerance test of diabetics: a comparison with tolbutamide. Current medical practice, 28, 712-5.

Block, E. (2010). Allium botany and cultivation, ancient and mdern. Garlic and other alliums: the lore and the science, 1-32.

Block, E. (2010). Garlic and Other Alliums. Allium Botany and Cultivation, Ancient and Modern. Royal Society of Chemistry (http://www. springer. com/978-0-85404-190-9), 11, 4-6.

Bordia, A. M. K. H. (1981). Effect of garlic on blood lipids in patients with coronary heart disease. The American journal of clinical nutrition, 34(10), 2100-2103.

Capraz, M., Dilek, M., & Akpolat, T. (2007). Garlic, hypertension and patient education. International journal of cardiology, 121(1), 130-131.

Chaiyakunapruk, N., Kitikannakorn, N., Nathisuwan, S., Leeprakobboon, K., & Leelasettagool, C. (2006). The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. American journal of obstetrics and gynecology, 194(1), 95-99.

Chen, B. H., Wu, P. Y., Chen, K. M., Fu, T. F., Wang, H. M., & Chen, C. Y. (2009). Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger). Journal of natural products, 72(5), 950-953.

Choi, Y. Y., Kim, M. H., Hong, J., Kim, S. H., & Yang, W. M. (2013). Dried ginger (Zingiber officinalis) inhibits inflammation in a lipopolysaccharide-induced mouse model. Evidence-based Complementary and Alternative Medicine, 2013.

Connell, D. W., & Sutherland, M. D. (1969). A re-examination of gingerol, shogaol, and zingerone, the pungent principles of ginger (Zingiber officinale Roscoe). Australian Journal of Chemistry, 22(5), 1033-1043.

Dini, C., Fabbri, A., & Geraci, A. (2011). The potential role of garlic (Allium sativum) against the multi-drug resistant tuberculosis pandemic: a review. Annali dell'Istituto superiore di sanità, 47, 465-473.

Dorant, E., van den Brandt, P. A., & Goldbohm, R. A. (1996). A prospective cohort study on the relationship between onion and leek consumption, garlic supplement use and the risk of colorectal carcinoma in The Netherlands. Carcinogenesis, 17(3), 477-484.

Duarte, M. C., Tavares, G. S., Valadares, D. G., Lage, D. P., Ribeiro, T. G., Lage, L. M., ... & Coelho, E. A. (2016). Antileishmanial activity and mechanism of action from a purified fraction of Zingiber officinalis Roscoe against Leishmania amazonensis. Experimental parasitology, 166, 21-28.

Dugasani, S., Pichika, M. R., Nadarajah, V. D., Balijepalli, M. K., Tandra, S., & Korlakunta, J. N. (2010). Comparative antioxidant and anti-inflammatory effects of [6]-gingerol,[8]-gingerol,[10]-gingerol and [6]-shogaol. Journal of ethnopharmacology, 127(2), 515-520.

Eidi, A., Eidi, M., & Esmaeili, E. (2006). Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine, 13(9-10), 624-629.

Eldin, I. M. T., Ahmed, E. M., & Abd Elwahab, H. M. (2009). Hypoglycemic activity and regeneration of pancreatic beta-cells produced by Allium cepa in alloxan-induced diabetic rats. Omdurman Journal of Pharmaceutical, 1(5), 562-8.

Everett, T. H. (1982). The New York botanical garden illustrated encyclopedia of horticulture (Vol. 10). Taylor & Francis.

Galeone, C., Pelucchi, C., Levi, F., Negri, E., Franceschi, S., Talamini, R., & La Vecchia, C. (2006). Onion and garlic use and human cancer. The American journal of clinical nutrition, 84(5), 1027-1032.

Gebreyohannes, G., & Gebreyohannes, M. (2013). Medicinal values of garlic: A review. International Journal of Medicine and Medical Sciences, 5(9), 401-408.

Griffiths, G., Trueman, L., Crowther, T., Thomas, B., & Smith, B. (2002). Onions—a global benefit to health. Phytotherapy research, 16(7), 603-615.

Gull, I., Saeed, M., Shaukat, H., Aslam, S. M., Samra, Z. Q., & Athar, A. M. (2012). Inhibitory effect of Allium sativum and Zingiber officinale extracts on clinically important drug resistant pathogenic bacteria. Annals of clinical microbiology and antimicrobials, 11(1), 1-6.

Ha, S. K., Moon, E., Ju, M. S., Kim, D. H., Ryu, J. H., Oh, M. S., & Kim, S. Y. (2012). 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology, 63(2), 211-223.

Hahn, G. (1996). History, folk medicine, and legendary uses of garlic. Garlic: the science and therapeutic application of Allium sativum L. and related species. Williams & Wilkins, Baltimore, Md, 1-24.

Hsing, A. W., Chokkalingam, A. P., Gao, Y. T., Madigan, M. P., Deng, J., Gridley, G., & Fraumeni Jr, J. F. (2002). Allium vegetables and risk of prostate cancer: a population-based study. Journal of the National Cancer Institute, 94(21), 1648-1651.

Imo, C., & Uhegbu, F. O. (2015). Phytochemical analysis of Gongronema latifolium Benth leaf using gas chromatographic flame ionization detector. Int J Chem Biomol Sci, 1(2), 60-68.

Imo, C., & Za’aku, J. S. (2019). Medicinal properties of ginger and garlic: A review. Curr Trends Biomedical Eng & Biosci, 18(2), 47-52.

Imo, C., Arowora, K. A., Awache, I., & Abdullahi, Z. R. (2016). Haematological Effects of Ethanolic Leaf, Seed and Fruit Extracts of Datura metel on Male Albino Rats. FUW Trends Sci. Tech. J, 1(2), 509-512.

Jabar, M. A., & Al-Mossawi, A. (2007). Susceptibility of some multiple resistant bacteria to garlic extract. African Journal of Biotechnology, 6(6).

Jeyaraj, S., Shivaji, G., Jeyaraj, S. D., & Vengatesan, A. (2006). Effect of combined supplementation of fish oil with garlic pearls on the serum lipid profile in hypercholesterolemic subjects. Alternative Medicine Review, 11(1), 65-66.

Josling, P. (2001). Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Advances in therapy, 18(4), 189-193.

Kasuga, S., Ushijima, M., Morihara, N., Itakura, Y., & Nakata, Y. (1999). Effect of aged garlic extract (AGE) on hyperglycemia induced by immobilization stress in mice. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 114(3), 191-197.

Kumar, A., Goyal, R., Kumar, S., Jain, S., Jain, N., & Kumar, P. (2015). Estrogenic and anti-Alzheimer’s studies of Zingiber officinalis as well as Amomum subulatum Roxb.: the success story of dry techniques. Medicinal Chemistry Research, 24(3), 1089-1097.

Lantz, R. C., Chen, G. J., Sarihan, M., Solyom, A. M., Jolad, S. D., & Timmermann, B. N. (2007). The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine, 14(2-3), 123-128.

Lanzotti, V. (2006). The analysis of onion and garlic. Journal of chromatography A, 1112(1-2), 3-22.

Lau, B. H. (2006). Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. The Journal of nutrition, 136(3), 765S-768S.

Lau, B. H., Lam, F., & Wang-Cheng, R. (1987). Effect of an odor-modified garlic preparation on blood lipids. Nutrition Research, 7(2), 139-149.

Ledezma, E., & Apitz-Castro, R. (2006). Ajoene the main active compound of garlic (Allium sativum): a new antifungal agent. Revista iberoamericana de micologia, 23(2), 75-80.

Li, Q. Q., Zhou, S. D., He, X. J., Yu, Y., Zhang, Y. C., & Wei, X. Q. (2010). Phylogeny and biogeography of Allium (Amaryllidaceae: Allieae) based on nuclear ribosomal internal transcribed spacer and chloroplast rps16 sequences, focusing on the inclusion of species endemic to China. Annals of botany, 106(5), 709-733.

Lim, T. K. (2012). Quercus infectoria. In Edible Medicinal And Non-Medicinal Plants (pp. 16-26). Springer, Dordrecht.

Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S., & Patapoutian, A. (2005). The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Current Biology, 15(10), 929-934.

Marrelli, M., Amodeo, V., Statti, G., & Conforti, F. (2019). Biological properties and bioactive components of Allium cepa L.: Focus on potential benefits in the treatment of obesity and related comorbidities. Molecules, 24(1), 119.

Mehdizadeh, M., Dabaghian, F., Nejhadi, A., Fallah-Huseini, H., Choopani, S., Shekarriz, N., ... & Asl, S. S. (2012). Zingiber officinale alters 3, 4-methylenedioxymethamphetamine-induced neurotoxicity in rat brain. Cell Journal (Yakhteh), 14(3), 177.

Mirelman, D., Monheit, D., & Varon, S. (1987). Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic extract (Allium sativum). Journal of Infectious Diseases, 156(1), 243-244.

Moghaddasi, M. S., & Kashani, H. H. (2012). Ginger (Zingiber officinale): A review. Journal of Medicinal Plants Research, 6(26), 4255-4258.

Morbidoni, L., Arterburn, J. M., Young, V., Mullins, D., Mulrow, C., & Lawrence, V. (2001). Garlic: Its history and adverse effects. Journal of Herbal Pharmacotherapy, 1(1), 63-83.

Morihara, N., Ushijima, M., Kashimoto, N., Sumioka, I., Nishihama, T., Hayama, M., & Takeda, H. (2006). Aged garlic extract ameliorates physical fatigue. Biological and Pharmaceutical Bulletin, 29(5), 962-966.

Morihara, N., Ushijima, M., Kashimoto, N., Sumioka, I., Nishihama, T., Hayama, M., & Takeda, H. (2006). Aged garlic extract ameliorates physical fatigue. Biological and Pharmaceutical Bulletin, 29(5), 962-966.

Morioka, N., Sze, L. L., Morton, D. L., & Irie, R. F. (1993). A protein fraction from aged garlic extract enhances cytotoxicity and proliferation of human lymphocytes mediated by interleukin-2 and concanavalin A. Cancer Immunology, Immunotherapy, 37(5), 316-322.

Nasri, H., Nematbakhsh, M., Ghobadi, S., Ansari, R., Shahinfard, N., & Rafieian-Kopaei, M. (2013). Preventive and curative effects of ginger extract against histopathologic changes of gentamicin-induced tubular toxicity in rats. International journal of preventive medicine, 4(3), 316.

Newall, C. A., Anderson, L. A., & Phillipson, J. D. (1996). Herbal medicines. A guide for health-care professionals. The pharmaceutical press.

Ohaeri, O. C. (2001). Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Bioscience reports, 21(1), 19-24.

Ozgoli, G., Goli, M., & Simbar, M. (2009). Effects of ginger capsules on pregnancy, nausea, and vomiting. The Journal of Alternative and Complementary Medicine, 15(3), 243-246.

Pecoraro, A., Patel, J., Guthrie, T., & Ndubisi, B. (1998, December). Efficacy of ginger as an adjunctive anti-emetic in acute chemotherapy-induced nausea and vomiting. In ASHP Midyear Clinical Meeting (Vol. 33, p. 429E).

Petchdee, S. (2012). Cardioprotective effects of garlic. KKU Veterinary Journal, 22(2), 242-254.

Prasad, K., Laxdal, V. A., Yu, M., & Raney, B. L. (1995). Antioxidant activity of allicin, an active principle in garlic. Molecular and Cellular Biochemistry, 148(2), 183-189.

Primatanti, P. A., & Jawi, I. M. (2019). Anthocyanin as neuroprotector for methamphetamine-induced neurotoxicity. International Journal of Health & Medical Sciences, 3(1), 11-16. https://doi.org/10.31295/ijhms.v3n1.101

Qureshi, S., Shah, A. H., Tariq, M., & Ageel, A. M. (1989). Studies on herbal aphrodisiacs used in Arab system of medicine. The American journal of Chinese medicine, 17(01n02), 57-63.

Raj, R. K. (1975). Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part--II. Indian Journal of Physiology and Pharmacology, 19(1), UNKNOWN-UNKNOWN.

Sabayan, B., Foroughinia, F., & Chohedry, A. (2007). A postulated role of garlic organosulfur compounds in prevention of valproic acid hepatotoxicity. Medical hypotheses, 68(3), 512-514.

Sabitha, P., Adhikari, P. M., Shenoy, S. M., Kamath, A., John, R., Prabhu, M. V., ... & Padmaja, U. (2005). Efficacy of garlic paste in oral candidiasis. Tropical doctor, 35(2), 99-99.

Salman, H., Bergman, M., Bessler, H., Punsky, I., & Djaldetti, M. (1999). Effect of a garlic derivative (alliin) on peripheral blood cell immune responses. International journal of immunopharmacology, 21(9), 589-597.

Shams-Ghahfarokhi, M., Shokoohamiri, M. R., Amirrajab, N., Moghadasi, B., Ghajari, A., Zeini, F., ... & Razzaghi-Abyaneh, M. (2006). In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia, 77(4), 321-323.

Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., ... & Steward, W. P. (2004). Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clinical Cancer Research, 10(20), 6847-6854.

Singh, D. K., & Singh, V. K. (2008). Pharmacological Effects of Allium Sativum L.(Garlic. Annual Review of Biomedical Sciences, 10, 6-26.

Steinmetz, K. A., Kushi, L. H., Bostick, R. M., Folsom, A. R., & Potter, J. D. (1994). Vegetables, fruit, and colon cancer in the lowa women's health study. American journal of epidemiology, 139(1), 1-15.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

Teshika, J. D., Zakariyyah, A. M., Zaynab, T., Zengin, G., Rengasamy, K. R., Pandian, S. K., & Fawzi, M. M. (2019). Traditional and modern uses of onion bulb (Allium cepa L.): a systematic review. Critical reviews in food science and nutrition, 59(sup1), S39-S70.

Török, B., Belagyi, J., Rietz, B., & Jacob, R. (1994). Effectiveness of garlic on the radical activity in radical generating systems. Arzneimittel-forschung, 44(5), 608-611.

Török, B., Belágyi, J., Rietz, B., & Jacob, R. (1994). Effectiveness of garlic on the radical activity in radical generating systems. Arzneimittel-Forschung, 44(5), 608–611.

Tsao, S. M., & Yin, M. C. (2001). In-vitro antimicrobial activity of four diallyl sulphides occurring naturally in garlic and Chinese leek oils. Journal of medical microbiology, 50(7), 646-649.

Uz, E., Karatas, O. F., Mete, E., Bayrak, R., Bayrak, O., Atmaca, A. F., ... & Akcay, A. (2009). The effect of dietary ginger (Zingiber officinals Rosc) on renal ischemia/reperfusion injury in rat kidneys. Renal failure, 31(4), 251-260.

Verma, S. K., Singh, J., Khamesra, R., & Bordia, A. (1993). Effect of ginger on platelet aggregation in man. The Indian journal of medical research, 98, 240-242.

Waggas, A. M. (2009). Neuroprotective evaluation of extract of ginger (Zingiber officinale) root in monosodium glutamate-induced toxicity in different brain areas male albino rats. Pakistan journal of biological sciences: PJBS, 12(3), 201-212.

Wojdyło, A., Oszmiański, J., & Czemerys, R. (2007). Antioxidant activity and phenolic compounds in 32 selected herbs. Food chemistry, 105(3), 940-949.

Wojdyło, A., Oszmiański, J., & Czemerys, R. (2007). Antioxidant activity and phenolic compounds in 32 selected herbs. Food chemistry, 105(3), 940-949.

Yeh, G. Y., Davis, R. B., & Phillips, R. S. (2006). Use of complementary therapies in patients with cardiovascular disease. The American journal of cardiology, 98(5), 673-680.

Published

14-08-2022

How to Cite

Das, S., Singh, K. R., Shrivastava, S., Khan, I., & Dhasmana, S. (2022). A comprehensive ethnopharmacological review on onion, garlic and ginger. International Journal of Health Sciences, 6(S5), 8584–8598. https://doi.org/10.53730/ijhs.v6nS5.10830

Issue

Section

Peer Review Articles