Recent approaches to combat various infections in eye

Punit Sharma; Anjna Rani

doi:10.53730/ijhs.v6nS5.10842

Authors

Punit Sharma Noida Institute of Engineering and Technology (Pharmacy Institute), knowledge park-II, Institutional area, Greater Noida (UP)-201306
Anjna Rani
anjna.sharma89@gmail.com
Assistant Professor, Noida Institute of Engineering and Technology (Pharmacy Institute), knowledge park-II, Institutional area, Greater Noida (UP)-201306

Keywords:

Ocular drug delivery, nanoparticles, liposomes, ocular implants, intraocular, bacterial infections

Abstract

The prevalence of various eye related disorder is increasing rapidly among the global population and the microorganism borne ocular infections are emerging as biggest threat to the healthy functioning of eye during the past few years. Conjunctivitis, keratitis, endophthalmitis, blepharitis, uveitis, cellulitis, and ocular herpes are a few of the more common ocular illnesses. The arrival of novel technologies including nanotechnology and ocular implant are giving a hope to the healthcare sector via improved therapeutic potential and safety profile in the field of ocular infections treatment. This article enlisted major ocular infections, along with the physiology, prevention and treatment methods. The review article also highlighted information related to the available treatments for various ocular infections and recent patent insight of emerging technologies.

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References

Agarwal R, Gupta SK, Srivastava S, Agrawal SS, Saxena R. Lowering of intraocular pressure by topical application of Daucus carota seed extract in rabbits.

Ahmed SN, Ahmad M, Zafar M, Rashid S, Yaseen G, Ashfaq S, Sultana S. Taxonomical and Phytochemical Characterization of Two Highly Traded Medicinal Species of Genus Berberis: Taxonomical and Phytochemical Characterization of two Medicinal Species of Genus Berberis. Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences. 2019;56(3):121-5.

Allam A, El-Mokhtar MA, Elsabahy M. Vancomycin-loaded niosomes integrated within pH-sensitive in-situ forming gel for treatment of ocular infections while minimizing drug irritation. Journal of Pharmacy and Pharmacology. 2019 Aug;71(8):1209-21.

Argüeso P, Woodward AM, AbuSamra DB. The Epithelial Cell Glycocalyx in Ocular Surface Infection. Front Immunol. 2021 Aug 23;12:729260.

Ashton, P. and H. Guo, Sustained release device and method for ocular delivery of adrenergic agents. 2004, Google Patents.

Baab S, Le PH, Kinzer EE. Allergic Conjunctivitis. 2021 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan

Badiee P. Mycotic keratitis, a state-of-the-art review. Jundishapur Journal of Microbiology. 2013 Jul 1;6(5):1S.

Badri T, Gandhi GR. Molluscum Contagiosum. 2021 Aug 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing

Bannenberg, G.L., C.N. Serhan, and F.M. Egea, Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors. 2020, Google Patents.

Barker NH, Thompson JM, Mullen MG, Weekes MA, Nguyen LN, Haynes CK, Miller D. Rhizobium radiobacter: a recently recognized cause of bacterial keratitis. Cornea. 2016 May 1;35(5):679-82.

Barry P, Cordovés L, Gardner S. ESCRS guidelines for prevention and treatment of endophthalmitis following cataract surgery: data, dilemmas and conclusions. European Society of Cataract and Refractive Surgeons. 2013:1-44.

Batiha GE, Alkazmi LM, Nadwa EH, Rashwan EK, Beshbishy AM, Shaheen H, Wasef L. Physostigmine: A plant alkaloid isolated from Physostigma venenosum: A review on pharmacokinetics, pharmacological and toxicological activities. Journal of Drug Delivery and Therapeutics. 2020 Feb 15;10(1-s):187-90.

Bi W, Gao Y, Shen J, He C, Liu H, Peng Y, Zhang C, Xiao P. Traditional uses, phytochemistry, and pharmacology of the genus Acer (maple): a review. Journal of ethnopharmacology. 2016 Aug 2;189:31-60.

Brandt, C.R., R.E. Kalil, and S. Agarwala, Replication competent, avirulent Herpes simplex virus as a vector for neural and ocular gene therapy. 2000, Google Patents.

Chen, D., Treatment of vascular abnormalities using nanoparticles. 2008, Google Patents.

Chu WK, Cheung SC, Lau RA. Bilberry (Vaccinium myrtillus L.) In: Benzie IFF, Wachtel-Galor S., editors. Herbal Medicine: Biomolecular and Clinical Aspects.

Codreanu M, Istudor V, Dociu N. Acer tataricum L. seeds-a new convenient source of gamma-linolenic acid. Acta Chromatographica. 2007 Jan 1;19:238.

Costa JR, Silva NC, Sarmento B, Pintado M. Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin. European Journal of Clinical Microbiology & Infectious Diseases. 2015 Jun;34(6):1255-62.

Cui M, Zheng M, Wiraja C, Chew SWT, Mishra A, Mayandi V, Lakshminarayanan R, Xu C. Ocular Delivery of Predatory Bacteria with Cryomicroneedles Against Eye Infection. AdvSci (Weinh). 2021 Nov;8(21):e2102327

Dadey, E., et al., Ocular delivery of polymeric delivery formulations. 2006, Google Patents.

Dawson CR, Bowman LM, inventors; Insite Vision Inc, assignee. Topical treatment or prevention of ocular infections. United States patent US 6,569,443. 2003 May 27.

Deepthi KG, Prabagaran SR. Ocular bacterial infections: Pathogenesis and diagnosis. Microbial Pathogenesis. 2020 Aug 1;145:104206.

Deepthi S, Jose J. Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis. International ophthalmology. 2019 Jun;39(6):1355-66.

Devilliers M, Barreau E, Da Cunha E, M’Garrech M, Bénichou J, Labetoulle M, Rousseau A. Atteintesophtalmologiques des infections virales Ocular manifestations of viral diseases. La Revue de Medecine Interne. 2020 Nov 6.

Devilliers MJ, Ben Hadj Salah W, Barreau E, Da Cunha E, M'Garrech M, Bénichou J, Labetoulle M, Rousseau A. Atteintes ophtalmologiques des infections virales [Ocular manifestations of viral diseases]. Rev Med Interne. 2021 Jun;42(6):401-410.

Devrim İ, Kanra G, Kara A, Cengiz AB, Orhan M, Ceyhan M, Seçmeer G. Preseptal and orbital cellulitis: 15-year experience with sulbactam ampicillin treatment. Turkish Journal of Pediatrics. 2008 May 1;50(3).

Donahue SP, Schwartz G. Preseptal and orbital cellulitis in childhood: a changing microbiologic spectrum. Ophthalmology. 1998 Oct 1;105(10):1902-6.

Donnenfeld E, Holland E. Dexamethasone intracameral drug-delivery suspension for inflammation associated with cataract surgery: a randomized, placebo-controlled, phase III trial. Ophthalmology. 2018 Jun 1;125(6):799-806.

Dos Santos GA, Ferreira-Nunes R, Dalmolin LF, dos Santos Ré AC, Anjos JL, Mendanha SA, Aires CP, Lopez RF, Cunha-Filho M, Gelfuso GM, Gratieri T. Besifloxacin liposomes with positively charged additives for an improved topical ocular delivery. Scientific reports. 2020 Nov 6;10(1):1-8.

Durgun ME, Kahraman E, Güngör S, Özsoy Y. Optimization and characterization of aqueous micellar formulations for ocular delivery of an antifungal drug, posaconazole. Current Pharmaceutical Design. 2020 Apr 1;26(14):1543-55.

Duxfield L, Sultana R, Wang R, Englebretsen V, Deo S, Swift S, Rupenthal I, Al-Kassas R. Development of gatifloxacin-loaded cationic polymeric nanoparticles for ocular drug delivery. Pharmaceutical Development and Technology. 2016 Feb 17;21(2):172-9.

Eberhardt M, Rammohan G. Blepharitis. 2022 Feb 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.

Fischetti V, Loomis L, inventors; New Horizons Diagnostics Corp, assignee. Composition for treatment of an ocular bacterial infection. United States patent US 6,406,692. 2002 Jun 18.

Gaibullaeva, N. N. (2021). The role of clinical examination early diagnosis of glaucoma. International Journal of Health & Medical Sciences, 4(3), 333-337. https://doi.org/10.31295/ijhms.v4n3.1745

GASCÓN, A.R., et al., Lipid nanoparticles for treating ocular diseases. 2013, Google Patents.

Gorle AP, Gattani SG. Development and evaluation of ocular drug delivery system. Pharmaceutical development and technology. 2010 Feb 1;15(1):46-52.

Gwon, A.E. and D. Meadows, Subconjunctival implants for ocular drug delivery. 1995, Google Patents.

Haji-Ali-Nili N, Khoshzaban F, Karimi M, Rahimi R, Ashrafi E, Ghaffari R, Ghobadi A, Behrouz MJ. Effect of a Natural Eye Drop, Made of Plantago Ovata Mucilage on Improvement of Dry Eye Symptoms: A Randomized, Double-blind Clinical Trial. Iranian Journal of Pharmaceutical Research: IJPR. 2019;18(3):1602.

Halasz, K.E.-A., Y.V. Pathak, and V.B. Sutariya, Nanoparticles for treatment of posterior segment ocular diseases and conditions. 2020, Google Patents.

Head K. Natural therapies for ocular disorders part two: cataracts and glaucoma. Alternative Medicine Review. 2001 Apr 1;6(2)

Hsiao CH, Sun CC, Yeh LK, Ma DH, Chen PY, Lin HC, Tan HY, Chen HC, Chen SY, Huang YC. Shifting trends in bacterial keratitis in Taiwan: a 10-year review in a tertiary-care hospital. Cornea. 2016 Mar 1;35(3):313-7.

Inana, G. and M. McLaren, Methods and compositions for detecting and treating retinal diseases. 2009, Google Patents.

Ismaiel AA, Rabie GH, Kenawey SE, EL-Aal MA. Efficacy of aqueous garlic extract on growth, aflatoxin B1 production, and cyto-morphological aberrations of Aspergillus flavus, causing human ophthalmic infection: topical treatment of A. flavus keratitis. Brazilian Journal of Microbiology. 2012 Dec;43(4):1355-64.

JONG SK. The study of chronic dacryocystitis: identification of pathogenic organism and histopathological findings. Journal of the Korean Ophthalmological Society. 1999:652-6.

Josyula A, Omiadze R, Parikh K, Kanvinde P, Appell MB, Patel P, Saeed H, Sutar Y, Anders N, He P, McDonnell PJ. An ion‐paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection. Bioengineering & translational medicine. 2021 Sep;6(3):e10238.

Kabir MH, Hasan N, Rahman MM, Rahman MA, Khan JA, Hoque NT, Bhuiyan MR, Mou SM, Jahan R, Rahmatullah M. A survey of medicinal plants used by the Deb barma clan of the Tripura tribe of Moulvibazar district, Bangladesh. Journal of Ethnobiology and Ethnomedicine. 2014 Dec;10(1):1-28.

Kalin-Hajdu E, Bernier-Turmel F, Frost É, Labbé AC, Couture S, Wong J, Boulos PR, Codère F, Hardy I. Helicobacter pylori Infection of the Gastric Mucosa and Ocular Adnexa-Lack of Association With Ocular Adnexal Lymphoma. Ophthalmic PlastReconstr Surg. 2021 May-Jun 01;37(3S):S1-S5.

Kalogeropoulos D, Kalogeropoulos C, Sakkas H, Mohammed B, Vartholomatos G, Malamos K, Sreekantam S, Kanavaros P, de-la-Torre A. Pathophysiological Aspects of Ocular Toxoplasmosis: Host-parasite Interactions. OculImmunolInflamm. 2021 Jul 9:1-10.

Karti O, Karahan E, Acan D, Kusbeci T. The natural process of congenital nasolacrimal duct obstruction and effect of lacrimal sac massage. International ophthalmology. 2016 Dec;36(6):845-9.

Koganti R, Yadavalli T, Naqvi RA, Shukla D, Naqvi AR. Pathobiology and treatment of viral keratitis. Exp Eye Res. 2021 Apr;205:108483.

Kraft, E.R., et al., Photokinetic ocular drug delivery methods and apparatus. 2015, Google Patents.

Lalitha P, Manoharan G, Karpagam R, Prajna NV, Srinivasan M, Mascarenhas J, Das M, Porco 7TC, Lietman TM, Cevallos V, Keenan JD. Trends in antibiotic resistance in bacterial keratitis isolates from South India. British Journal of Ophthalmology. 2017 Feb 1;101(2):108-13.

Larsen BH, Soelberg J, Jäger AK. COX-1 inhibitory effect of medicinal plants of Ghana. South African Journal of Botany. 2015 Jul 1;99:129-31.

Lawrence R, Jeyakumar E, Gupta A. Antibacterial Activity of Acacia arabica (Bark) Extract against selected multi drug resistant pathogenic bacteria. Int J Curr Microbiol App Sci. 2015;1:213-2.

Lee S, Yen MT. Management of preseptal and orbital cellulitis. Saudi Journal of Ophthalmology. 2011 Jan 1;25(1):21-9.

Leffler CT, Schwartz SG, Wainsztein RD, Pflugrath A, Peterson E. Ophthalmology in North America: early stories (1491-1801). Ophthalmology and eye diseases. 2017 Jul 25;9:1179172117721902.

Lemp MA, Nichols KK. Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment. The ocular surface. 2009 Apr 1;7(2):S1-4.

Leonardi A. Vernal keratoconjunctivitis: pathogenesis and treatment. Progress in retinal and eye research. 2002 May 1;21(3):319-39.

Li JJ, Yi S, Wei L. Ocular Microbiota and Intraocular Inflammation. Frontiers in Immunology. 2020:3388.

Liu J, Sheha H, Tseng SC. Pathogenic role of Demodex mites in blepharitis. Current opinion in allergy and clinical immunology. 2010 Oct;10(5):505.

Magwa ML, Gundidza M, Gweru N, Humphrey G. Chemical composition and biological activities of essential oil from the leaves of Sesuvium portulacastrum. Journal of Ethnopharmacology. 2006 Jan 3;103(1):85-9.

Makwana SB, Patel VA, Parmar SJ. Development and characterization of in-situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Results in pharma sciences. 2016 Jan 1;6:1-6.

Mandal B, Alexander KS, Riga AT. Sulfacetamide loaded Eudragit RL100 nanosuspension with potential for ocular delivery. J Pharm Pharm Sci. 2010 Jan 1;13(4):510-23.

Marasini S, Swift S, Dean SJ, Ormonde SE, Craig JP. Spectrum and sensitivity of bacterial keratitis isolates in Auckland. Journal of ophthalmology. 2016 Jan 1;2016.

Maroyi A. Use of herbal formulations for the treatment of circumcision wounds in Eastern and Southern Africa. Plant Science Today. 2021 Jul 1;8(3):517-27.

Matoba AL. Ocular viral infections. Pediatric infectious disease. 1984 Jul 1;3(4):358-68

Meher B, Dash DK, Roy A. A review on: Phytochemistry, pharmacology and traditional uses of Tamarindus indica L. WJPPS. 2014 Jul 20;3(10):229-40.

Miller D, Iovieno A. The role of microbial flora on the ocular surface. Current opinion in allergy and clinical immunology. 2009 Oct 1;9(5):466-70.

Minor M, Payne E. Herpes Zoster Ophthalmicus. 2021 Aug 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing

Mowery, B.P., et al., Ocular microcurrent stimulation therapy method and system. 2021, Google Patents.

Naash, M.I. and M.J. Cooper, Use of compacted nucleic acid nanoparticles in non-viral treatments of ocular diseases. 2009, Google Patents.

Ozkan J, Willcox MD. The ocular microbiome: molecular characterisation of a unique and low microbial environment. Current eye research. 2019 Jul 3;44(7):685-94.

Patel D, Wairkar S. Recent advances in cyclosporine drug delivery: Challenges and opportunities. Drug Delivery and Translational Research. 2019 Dec;9(6):1067-81.

Pattanayak S. Alternative to antibiotics from herbal origin–outline of a comprehensive research project. Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics). 2018 Apr 1;16(1):9-62.

Perween N, Bisht D, Aggarwal P. Bacterial conjunctivitis: microbiological profile, antimicrobial susceptibility patterns and recommendations for treatment. J. Commun. Dis. 2016;48:1.

Petropoulos SA, Plexida S, Tzortzakis N, Ferreira IC. Phytochemicals Content and Health Effects of Abelmoschus esculentus (Okra). Phytochemicals in Vegetables: A Valuable Source of Bioactive Compounds. 2018 Nov 15:404.

Poddar S, Sarkar T, Choudhury S, Chatterjee S, Ghosh P. Indian traditional medicinal plants: A concise review. International Journal of Botany Studies. 2020;5(5):174-90.

Pradeep AV, Patil SS, Koti SV, Arunkumar JS, Garag SS, Hegde JS. Clinico-bacteriological study of chronic dacryocystitis cases in northern karnataka, India. Journal of Clinical and Diagnostic Research: JCDR. 2013 Nov;7(11):2502.

Prausnitz, M.R., N. Jiang, and H.F. Edelhauser, Method for drug delivery to ocular tissue using microneedle. 2011, Google Patents.

Putnam CM. Diagnosis and management of blepharitis: an optometrist’s perspective. Clinical Optometry. 2016;8:71.

Roy, P., Irritation-reducing ocular iontophoresis device. 2009, Google Patents.

Salvi V, Pawar P. Eudragit RL100 Based Moxifloxacin Hydrochloride and Ketorolac Tromethamine Combination Nanoparticulate System for Ocular Drug Delivery. Pharmaceutical Nanotechnology. 2020 Apr 1;8(2):133-47.

Sandhu PS, Singh B, Gupta V, Bansal P, Kumar D. Potential herbs used in ocular diseases. Journal of pharmaceutical sciences and research. 2011 Apr 1;3(4):1127.

Shikamura Y, Yamazaki Y, Matsunaga T, Sato T, Ohtori A, Tojo K. Hydrogel ring for topical drug delivery to the ocular posterior segment. Current Eye Research. 2016 May 3;41(5):653-61.

Singh P, Gupta A, Tripathy K. Keratitis. 2022 Feb 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan

Slade DS, Friday JW, Snyder RW, Nix DE, Kleinert LB, Patula VB. Prophylactic gatifloxacin therapy in prevention of bacterial keratitis in a rabbit laser in situ keratomileusis model. Journal of Cataract & Refractive Surgery. 2007 May 1;33(5):888-92.

Smith RE, Flowers Jr CW. Chronic blepharitis: a review. CLAO Journal-Contact Lens Assn of Ophthalmologists. 1995 Jul 1;21(3):200-7.

Sobolewska B, Doycheva D, Deuter C, Pfeffer I, Schaller M, Zierhut M. Treatment of ocular rosacea with once-daily low-dose doxycycline. Cornea. 2014 Mar 1;33(3):257-60.

Srikanth M. In Vitro Anticataract Activity of Tamarindus Indica Linn. Againest Glucose-Induced Cataractogenisis (Doctoral dissertation, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore).

Srivastava D, Shukla K. Viral Diseases on Medicinal Plants of North-Eastern Uttar Pradesh. InPlant Viruses: Evolution and Management 2016 (pp. 89-129). Springer, Singapore.

Stimes GT, Girotto JE. Applying pharmacodynamics and antimicrobial stewardship to pediatric preseptal and orbital cellulitis. Pediatric Drugs. 2019 Dec;21(6):427-38.

Sultana Y, Aqil M, Ali A. Ocular inserts for controlled delivery of pefloxacin mesylate: Preparation and evaluation. Acta pharmaceutica. 2005 Sep 1;55(3):305-14.

Surse Sunita N. Celosia cristata: Potent Pharmacotherapeutic Herb–A Review.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Tareen RB, Bibi T, Khan MA, Ahmad M, Zafar M, Hina S. Indigenous knowledge of folk medicine by the women of Kalat and Khuzdar regions of Balochistan, Pakistan. Pak J Bot. 2010 Jun 1;42(3):1465-85.

Taylor RS, Ashurst JV. Dacryocystitis. 2022 Feb 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan

Teh SW, Mok PL, Abd Rashid M, Bastion ML, Ibrahim N, Higuchi A, Murugan K, Mariappan R, Subbiah SK. Recent updates on treatment of ocular microbial infections by stem cell therapy: a review. International journal of molecular sciences. 2018 Feb;19(2):558.

Ugandar RE, Sharma DK, Krishnan D, Nilu KC. TRANSCORNEAL PERMEATION OF OFLOXACIN BY AMINO ACID TRANSPORTERS. International Journal of Pharmaceutical Sciences and Research. 2016 Jan 1;7(1):363.

Varela-Garcia A, Concheiro A, Alvarez-Lorenzo C. Soluplus micelles for acyclovir ocular delivery: Formulation and cornea and sclera permeability. International Journal of Pharmaceutics. 2018 Dec 1;552(1-2):39-47.

Venkatesh A, Patel R, Goyal S, Rajaratnam T, Sharma A, Hossain P. Ocular manifestations of emerging viral diseases. Eye (Lond). 2021 Apr;35(4):1117-1139.

Vickers NJ. Animal communication: when i’m calling you, will you answer too?. Current biology. 2017 Jul 24;27(14):R713-5.

Vonk AG, Netea MG, Van Krieken JH, Iwakura Y, Van Der Meer JW, Kullberg BJ. Endogenous interleukin (IL)–1α and IL-1β are crucial for host defense against disseminated candidiasis. The Journal of infectious diseases. 2006 May 15;193(10):1419-26.

Whitcher JP, Srinivasan M, Upadhyay MP. Corneal blindness: a global perspective. Bulletin of the world health organization. 2001;79:214-21.

X3 Tummanapalli SS, Willcox MD. Antimicrobial resistance of ocular microbes and the role of antimicrobial peptides. ClinExpOptom. 2021 Apr;104(3):295-307

Xia, E. and R.V. Smerbeck, Reversible gelling system for ocular drug delivery. 2004, Google Patents.

Yadav DK. Pharmacognostical, phytochemical and pharmacological profile of Colebrookea oppositifolia Smith. Journal of Drug Delivery and Therapeutics. 2019 Dec 15;9(6-s):233-7.

Yang X, Wang L, Li L, Yu Z, Xiao C. The Imbalance of Lymphocyte Subsets and Cytokines: Potential Immunologic Insights into the Pathogenesis of Chronic Dacryocystitis. Investigative Ophthalmology & Visual Science. 2018 Apr 1;59(5):1802-9.

Yin D, Ling S, Wang D, Dai Y, Jiang H, Zhou X, Paludan SR, Hong J, Cai Y. Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice. Nat Biotechnol. 2021 May;39(5):567-577