A clinical study on biochemical profile of neonatal seizures in a medical college hospital

https://doi.org/10.53730/ijhs.v6nS6.10857

Authors

  • Mahaboob Basha Kallur Professor & HOD, Department of Paediatrics, Mamata Academy of Medical Sciences, Bachupally, Hyderabad, Telangana
  • Keziah Joseph Associate Professor, Department of Paediatrics, Mamata Academy of Medical Sciences, Bachupally, Hyderabad, Telangana

Keywords:

neonatal seizures, biochemical abnormalities, anticonvulsants

Abstract

Background: Neonatal seizures are one of the most common and distinctive clinical manifestations of dysfunction of neurological system. Neonatal seizures represent non-specific responses of the immature nervous system to varied insults and result in considerable neonatal mortality and long- term morbidity including motor and cognitive disabilities in the childhood. OBJECTIVES: To study the biochemical abnormalities associated with neonatal seizures. To study the clinical presentation, time of onset and its relation to the neonatal seizures in new-born unit. Material & Methods: Study Design: Prospective hospital based observational study. Study area: Dept. of. Paediatrics, Mamata Academy of Medical Sciences, Bachupally, Hyderabad, Telangana. Study Period: June 2021 – May 2022. Study population: All the neonates from birth to 28 days of life satisfying the inclusion and exclusion criteria who got admitted in the Neonatal Intensive Care Unit of Department of Pediatrics. Sample size: study consisted a total of 80 cases. Study tools and Data collection procedure: Written informed consent was taken from the parent or caregivers prior to the enrolment of neonate for the study. 

Downloads

Download data is not yet available.

References

Aziz A. Gattoo, M Aziz, G Rasool. Clinical and etiological profile of neonatal seizures: A tertiary care hospital based study Int J Res Med Sci. 2015 Sep; 3(9): 2198-2203.

Das, Dinesh, and Sanjib Kumar Debbarma. "A Study on Clinico- Biochemical Profile of Neonatal Seizure." Journal of Neurology Research 6.5-6 (2016): 95-101.

Davis AS, Hintz SR, Van KP, LiL, Das A, Stoll BJ et al. Seizures in extremely low birth weight infants are associated with adverse outcome.JPediatr.2010;157(5):720-5.

Dwijayanti, N., Mufdlilah, M., & Suryaningsih, E. K. (2022). The role of midwives in the application of classroom services for pregnant women during the COVID-19 pandemic period. International Journal of Health & Medical Sciences, 5(3), 228-239. https://doi.org/10.21744/ijhms.v5n3.1918

Holanda MRR, Melo AN. Comparative clinical study of preterm and full- term newborn neonatal seizures. Arq Neuropsiquiatr2006;64:282–8.

Kumar A, Gupta V, Kachhawaha JS, Singla PN. Biochemical Abnormalities in neonatal seizures. Indian Pediatr.1995;32(4):424-428.

Madhusudhan K, Nadavapalli Suresh S, Babu TR, Rao JV, Kumar S B. Study of biochemical abnormalities in neonatalseizures with specialreferencetohyponatremia.IntJContempPediatr2016;3:730-4.

Mikati MA, Kliegman RM, Behrman RE, Stanton BF. Seizures in childhood; Nelson textbook of Paediatrics,19th edition. Philadelphia. 2011: WB Saunders [586]:2013-2037.

MillerSP, WeissJ, BarnwallA, Ferriero DM, Latal HB, Ferrer RA et al.

Nawab T, Lakshmipathy NS. Clinical profile of neonatal seizures with special reference to biochemical abnormalities. Int J ContempPediatr2016;3:183-8.

Oden J, Bourgeois M. Neonatal endocrinology. Indian J Pediatr2000;67:217-23

Park, Weon, et al. "Clinical study of neonatal seizure." Journal of the Korean Child Neurology Society 6.1 (1998): 71-82.

Seizure-associated brain injury in term newborn with perinatal asphyxia. Neurology.2002;58(4):542-8.

Sood A, Grover N, Sharma R. Biochemical abnormalities in neonatal seizures. Indian Journal of Paed. 2003;70(3):221-4.

Sudia S, Berwal PK, NagarajN, Jeavaji P, Swami S, Berwal A.Clinicoetiologicalprofile and outcome of neonatal seizures. Int JContempPediatr2015;2:389-90.

Sudia, Sanjeev, et al. "Clinicoetiological profile and outcome of neonatal seizures." International Journal of Contemporary Pediatrics 2.4 (2017): 389-394.

Suganthi V, Vikneshwari K, Thivya G. Prevalence of hypomagnesemia in neonatal seizures in a tertiary care hospital inSouth India. J PediatrRes.2017;4(01):64-68.doi:10.17511/ijpr.2017.01.13.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

Tekgul H, Gauvreau K, Soul J, et al. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics 2006;117:1270 –1280.

William W, Hay Jr, Tonse NK Raju, et al. Knowledge gaps and research needs for understanding and treating neonatal hypoglycemia: Workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development. J Pediatr 2009; 155: 612-17.

Yadav R K, Sharma I K, Kumar D, Shukla K M, Jawwad K , Chaturvedi V. Clinicoetiological and Biochemical Profile Of Neonatal Convulsions.Int J Med Res Rev 2015;3(9):1057-1063. doi: 10.17511/ijmrr.2015.i9.193.

Published

20-07-2022

How to Cite

Kallur, M. B., & Joseph, K. (2022). A clinical study on biochemical profile of neonatal seizures in a medical college hospital. International Journal of Health Sciences, 6(S6), 4701–4710. https://doi.org/10.53730/ijhs.v6nS6.10857

Issue

Section

Peer Review Articles