The relationship between GSH enzyme with risk of childhood acute lymphoblastic leukemia ALL

Maryam Isam Abdullah; Alaa Shakir Al-Nahi

doi:10.53730/ijhs.v6nS6.10909

Authors

Maryam Isam Abdullah Department of Biology, Faculty of Science, University of Kufa, Iraq
Alaa Shakir Al-Nahi Department of Biology, Faculty of Science, University of Kufa, Iraq

Keywords:

GSH enzyme, childhood, acute, lymphoblastic, leukemia

Abstract

Total sample number 90 were 60 children diagnosed with Acute lymphoblastic leukemia (ALL) collect form Center Tumor cancer in Najaf , Warith international cancer institute in Karbala and select 30 children normal heath ( control) from Amir al-Muminin Hospital and study conduct with molecular lab biology in the Department of Biology / Faculty of Science – University of Kufa, during the period from November 2021 to April 2022, The study demonstrated that there are highly significant differences in the enzyme GSH between those who carry the allele null in patients and control GSTT1, GSTM1and GSTT1&GSTM1 (2.05±1.40 , 2.27±1.73,2.21±1.5) and (3.7±1.9, 3.2±1.8, 3.86±1.7) respectively , the allele present in patients and control GSTT1, GSTM1,and GSTT1&GSTM1 (5.33±0.38 ,4.78±0.68, 5.03±0.7) , (10.64±1.7 , 9.73±2.7 , 9.9±2.5) respectively.

Downloads

Download data is not yet available.

References

Abdalhabib, E. K., Alzahrani, B., Alanazi, F., Algarni, A., Ibrahim, I. K., Mohamed, H. A., ... & Saboor, M. (2022). Increased risk of acute lymphoblastic leukemia in adult patients with gstm1 null genetic polymorphism. Pharmacogenomics and personalized medicine, 15, 227.

Anantharaman, D., Chaubal, P. M., Kannan, S., Bhisey, R. A., & Mahimkar, M. B. (2007). Susceptibility to oral cancer by genetic polymorphisms at cyp1a1, gstm1 and gstt1 loci among indians: tobacco exposure as a risk modulator. Carcinogenesis, 28(7), 1455-1462.

Aziz, I. H. (2010). Screening for Genetic Polymorphisms of Glutathione-S-Transferase Genes and Risk Factors Among Breast Cancer Patients in Iraq. Iraqi Journal of Cancer and Medical Genetics, 3(2).

Baba, S. M., Pandith, A. A., Shah, Z. A., Geelani, S. A., Bhat, J. R., Gul, A., ... & Mansoor, S. (2021). Gstt1 null and rs156697 polymorphism in gsto2 influence the risk and therapeutic outcome of b-acute lymphoblastic leukemia patients. Frontiers in oncology, 11, 714421

Cameron, J. K., & Baade, P. (2021). Projections of the future burden of cancer in australia using bayesian age-period-cohort models. Cancer epidemiology, 72, 101935.

Cerliani, M. B., Pavicic, W., Gili, J. A., Klein, G., Saba, S., & Richard, S. (2016). Cigarette smoking, dietary habits and genetic polymorphisms in gstt1, gstm1 and cyp1a1 metabolic genes: a case-control study in oncohematological diseases. World journal of clinical oncology, 7(5), 395

Dusinska, M., Staruchova, M., Horska, A., Smolkova, B., Collins, A., Bonassi, S., & Volkovova, K. (2012). Are glutathione s transferases involved in dna damage signalling? Interactions with dna damage and repair revealed from molecular epidemiology studies. Mutation research/fundamental and molecular mechanisms of mutagenesis, 736(1-2), 130-137.

Hollman, A. L., Tchounwou, P. B., & Huang, H. C. (2016). The association between gene-environment interactions and diseases involving the human gst superfamily with snp variants. International journal of environmental research and public health, 13(4), 379.

Huang, G. Z., Shan, W., Zeng, L., & Huang, L. G. (2013). The gstp1 a1578g polymorphism and the risk of childhood acute lymphoblastic leukemia: results from an updated meta-analysis. Genet mol res, 12(3), 2481-2491.

Karaca, S., Karaca, M., Cesuroglu, T., Erge, S., & Polimanti, R. (2015). Gstm1, gstp1, and gstt1 genetic variability in t urkish and worldwide populations. American journal of human biology, 27(3), 310-316.

Ma, D. Q. (2019). Gstt1 null genotype and susceptibility to children acute leukemia in chinese population: evidence from a meta-analysis. Technology in cancer research & treatment, 18, 1533033819867361

Mohseni, M., Uludag, H., & Brandwein, J. M. (2018). Advances in biology of acute lymphoblastic leukemia (all) and therapeutic implications. American journal of blood research, 8(4), 29.

Moulik, N. R., Parveen, F., Kumar, A., & Agrawal, S. (2014). Glutathione-s-transferase polymorphism and acute lymphoblastic leukemia (all) in north indian children: a case–control study and meta-analysis. Journal of human genetics, 59(9), 529-535.

Safitri, Y. D., Atho'illah, M. F., Nur'aini, F. D., Widyarti, S., & Rifa'i, M. (2018). The effects of elicited soybean (glycine max) extract on hematopoietic cells of high fat-fructose diet balb/c mice model. Jordan journal of biological sciences, 11(3).

Singh, R. R., & Reindl, K. M. (2021). Glutathione s-transferases in cancer. Antioxidants, 10(5), 701.

Strange, R. C., Spiteri, M. A., Ramachandran, S., & Fryer, A. A. (2001). Glutathione-s-transferase family of enzymes. Mutation research/fundamental and molecular mechanisms of mutagenesis, 482(1-2), 21-26.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

Yarmukhamedova, N. F., Matkarimova, D. S., Bakieva, S. K., & Salomova, F. I. (2021). Features of the frequency of distribution of alleles and genotypes of polymorphisms of the gene Tnf-A (G-308a) in patients with rhinosinusitis and the assessment of their role in the development of this pathology. International Journal of Health & Medical Sciences, 4(1), 164-168. https://doi.org/10.31295/ijhms.v4n1.1671

Yaya, K., Hind, D., Meryem, Q., Asma, Q., Said, B., & Sellama, N. (2014). Single nucleotide polymorphisms of multidrug resistance gene 1 (mdr1) and risk of chronic myeloid leukemia. Tumor biology, 35(11), 10969-10975.