Chitosan and Hydroxypropyl Methylcellulose as release retardant for Aceclofenac
Keywords:
chitosan, HPMC K 15 M, tablet, drug releaseAbstract
Plenty of natural polymers has been found effective to modulate the drug release. Numerous natural polymers either alone or in combination with other polymers were found effective in controlling the drug release. In the current study attempts were made to combine chitosan (degree of deacetylation 88.42 %, Molecular weight 50,000 Da, and viscosity 93 CPS) and HPMC K 15M to retard the release of aceclofenac in tablet formulation. The tablets were prepared by wet granulation method and evaluated for pre and post- compression parameters. All the pre-compression parameters were found within the limit. The mechanical strength was determined in terms of hardness and friability values these were found in the range of 4.16-5.22 kg/cm2 and 0.1-0.75% respectively. The drug content was found in the range of 97.51 – 99.66 %. Weight variation test complied the official limit as per Indian Pharmacopoeia. With increasing the concentration of both the polymers the swelling index was increased and drug release decrease. Highest concentration of both the polymers was found to retard the drug release up to 8 h.
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References
Nagashree K, Solid dosage forms: Tablets,Research and Reviews: Journal of Pharmaceutical Analysis, 2015, 4(2), 60-71
Agarwal G, Agarwal S, Karar PK andGoyal S, Oral sustained release tablets: An overview with a special emphasis on matrix tablet,American Journal of Advanced Drug Delivery, 2017, 5(2), 64-76.
Zalte H D andSaudagar R B, Review on sustained release matrix tablet,Int J Pharm BiolSci, 2013, 3(4), 17-29.
Menkudale A, Khuspe P, Otari K, Khemnar M and Kulkarni V, An updated review on applications of natural polymers in sustained release drug delivery system, 2020, 2(1), 43-47.
Kadam VS andShendarkar G R, Role of natural polymer in sustained and controlled release,Indo American journal of pharmaceutical research. 2017, 7(01), 7390-7400.
Enayatifard R, Saeedi M, Akbari J andTabatabaee Y H,Effect of hydroxypropyl methylcellulose and ethyl cellulose content on release profile and kinetics of diltiazem HCL from matrices, Tropical Journal of Pharmaceutical Research, 2009, 8(5), 425-432.
Bhardwaj TR, Kanwar M, Lal R, et al., Natural gums and modified natural gums as sustained-release carriers,Drug Development and Industrial Pharmacy, 2000, 26(10), 1025- 1038.
Faiyaz S, Wafa R and Sheikh S, Solubility and dissolution improvement of aceclofenac using different nanocarriers,J BioequivAvailab, 2009, 1, 39-43.
Kandekar U Y, Tapkir M H, Bhalerao PH, Rukhe N B and Kad S K,Colocasiaesculenta starch: Novel alternative disintegrant for pharmaceutical application, Indian Drugs, 2021.
Koirala S, NPrabin, GhimireG, BasnetR, RawatIet al. Formulation and evaluation of mucoadhesivebuccal tablets of aceclofenac,Heliyon, 7 (3), e06439.
Kandekar UY, AbhangT R, PujariRR and Khandelwal K R, Exploration of Elephant Foot Yam (Amorphophallus paeoniifolius) Starch: An Alternative natural disintegrant for pharmaceutical application,Indian Journal of Pharmaceutical Education and Research, 2021, 55 (1), S209-S219.
Katedeshmukh, Ramesh G, and YadavA V, Development of matrix tablet of Aceclofenac with chitosan and hydroxypropyl methyl cellulose (HPMC) as co-polymer,American Journal of PharmTech Research, 2013, 3 (6), 638-658.
Elgaied-Lamouchi D, DescampsN, LefevreP, RamburI, PierquinJ Y, SiepmannF, SiepmannJ, MuschertS, Starch-based controlled release matrix tablets: Impact of the type of starch, Journal of Drug Delivery Science and Technology,2021, 61, 102-152.
Giri B R, Jaewook K,VoA Q, BhagurkarA M, BandariS, Dong W K, Hot-melt extruded amorphous solid dispersion for solubility, stability, and bioavailability enhancement of Telmisartan, Pharmaceuticals,2021, 14 (1), 73.
Blanco D, Osmo A, Heikki R, Jouko Y, and Anne M J, Effect of colloidal silicon dioxide and moisture on powder flow properties: Predicting in-process performance using image-based analysis,International Journal of Pharmaceutics,2021, 597, 120344.
Paul S and Changquan C. Dependence of friability on tablet mechanical properties and a predictive approach for binary mixtures. Pharmaceutical Research2017, 34 (12), 2901-2909.
Goh HP, Paul W S H and Celine V L, Understanding die fill variation during mini-tablet production,International Journal of Pharmaceutics,2017, 534 (1-2), 279-286.
Nunthanid J M, Luangtana A P,Sriamornsak S L, HuanbuttaKand PuttipipatkhachornS, Use of spray-dried chitosan acetate and ethylcellulose as compression coats for colonic drug delivery: Effect of swelling on triggering in vitro drug release, European Journal of Pharmaceutics and Biopharmaceutics,2009,71(2), 56-361.
Barba AAa, d’AmoreM, ChiricoS, LambertiG and TitomanlioG, Swelling of cellulose derivative (HPMC) matrix systems for drug delivery, Carbohydrate Polymers, 2009, 78 (3), 469-474.
Mamani P L, Roberto RC and VeigaMD, Matrix tablets: the effect of hydroxypropyl methylcellulose/anhydrous dibasic calcium phosphate ratio on the release rate of a water-soluble drug through the gastrointestinal tract I. In vitro tests,AapsPharmscitech,. 2012, 13 (4), 1073-1083.
Roy, Harekrishna, and BhabaniNayak. 2017. "Formulation and design of sustained release matrix tablets of lamivudine: Combination of chitosan and HPMC." American Journal of Pharmacy and Health Research 5 (2):1-10.
HuanbuttaK, Kamonrak C, Katsuhide T, Jurairat N and Pornsak S, Impact of salt form and molecular weight of chitosan on swelling and drug release from chitosan matrix tablets,Carbohydrate polymers,2013, 97 (1), 26-33.
Sriamornsak P, Nartaya T and Kingkarn K, Swelling, erosion and release behavior of alginate-based matrix tablets, European Journal of Pharmaceutics and Biopharmaceutics, 2007, 66 (3), 435-450.
Rao TV, Kiran KumarGB, Mohammed GA and JoshiV, Development and evaluation of chitosan based oral controlled matrix tablets of losartan potassium,International Journal of Pharmaceutical Investigation2012, 2 (3), 157-161.
Leon H A L, and Joseph L K. The theory and practice of industrial pharmacy: Lea & Febiger.1986.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Mustafa, A. R., Ramadany, S., Sanusi, Y., Made, S., Stang, S., & Syarif, S. (2020). Learning media applications for toddler midwifery care about android-based fine motor development in improving midwifery students skills. International Journal of Health & Medical Sciences, 3(1), 130-135. https://doi.org/10.31295/ijhms.v3n1.290
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