Study of midkine protein as prognostic marker for thyroid disease in Al-Najaf City

Murtadha M. Jawad; Asmaa H. Hussein

doi:10.53730/ijhs.v6nS5.10928

Authors

Murtadha M. Jawad
kuh.dr.mur@atu.edu.iq
College of Health and Medical Techniques, Kufa, Al-Furat Al-Awsat University
Asmaa H. Hussein College of Health and Medical Techniques, Kufa, Al-Furat Al-Awsat University

Keywords:

Hyperthyroidism, Hypothyroidism, MidKine

Abstract

Objectives: The aim of this study is to detection of various thyroid diseases in the early stages and their impact on the metabolic state of the body through the estimation of the Midkine by using ELISA method. Methadology: The current study was conducted on 45 patients with thyroid disease was attending in endocrine and diabetic center in the Al-Sadder Teaching Hospital and Al-Hakim General Hospital in AL-Najaf Province, and 45 healthy person, the samples collected during the period from September 2021 to 2`January. Results: The result of hormonal markers shows high significant with p-value = <0.001 in the level of T3 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. On the other hand, this result was high significant with p-value = <0.001 in the level of T4 was higher in Hypothyroidism compared to Hyperthyroidism and the control group. In addition, this result was high significant with p-value = <0.001 in the level of TSH was higher in Hyperthyroidism compared to Hypothyroidism and the control group. The results of biochemical marker of Midkine was higher in Hyperthyroidism and Hypothyroidism (499.6 ± 120.2 and 489.1 ± 108.1 respectively) compared to and the control group (372.9 ± 92.5).

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References

Anchundia, M. J. L., Gámez, M. R., Quiroz, A. M. V., Miles, G. M., & Molina, L. A. V. (2022). Energy efficiency and the link with society. International Research Journal of Management, IT and Social Sciences, 9(4), 398-404. https://doi.org/10.21744/irjmis.v9n4.2094

Anwar, S., & Anwar, A. (2016). Infertility: A review on causes, treatment and management. Womens Health Gynecol, 5, 2-5.‏

Asmelash, D., Tesfa, K., & Biadgo, B. (2019). Thyroid dysfunction and cytological patterns among patients requested for thyroid function test in an endemic goiter area of Gondar, North West Ethiopia. International Journal of Endocrinology, 2019.‏

Åsvold, B. O., Vatten, L. J., Midthjell, K., & Bjøro, T. (2012). Serum TSH within the reference range as a predictor of future hypothyroidism and hyperthyroidism: 11-year follow-up of the HUNT Study in Norway. The Journal of Clinical Endocrinology & Metabolism, 97(1), 93-99.‏

Beynon, M. E., & Pinneri, K. (2016). An overview of the thyroid gland and thyroid-related deaths for the forensic pathologist. Academic forensic pathology, 6(2), 217-236.‏

Cai, Y. Q., Lv, Y., Mo, Z. C., Lei, J., Zhu, J. L., & Zhong, Q. Q. (2020). Multiple pathophysiological roles of midkine in human disease. Cytokine, 135, 155242.‏

Carlé, A., Pedersen, I. B., Knudsen, N., Perrild, H., Ovesen, L., & Laurberg, P. (2015). Gender differences in symptoms of hypothyroidism: a population-based DanThyr study. Clinical endocrinology, 83(5), 717-725.‏

Castello, R., & Caputo, M. (2019). Thyroid diseases and gender. Italian Journal of Gender-Specific Medicine, 5(3), 136-141.‏

Corio, L. (2013). The change before the change: Everything you need to know to stay healthy in the decade before menopause.

Devereaux, D., & Tewelde, S. Z. (2014). Hyperthyroidism and thyrotoxicosis. Emergency Medicine Clinics, 32(2), 277-292.‏

Filippou, P. S., Karagiannis, G. S., & Constantinidou, A. (2020). Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target. Oncogene, 39(10), 2040-2054.‏

Gowhari Shabgah, A., Ezzatifar, F., Aravindhan, S., Olegovna Zekiy, A., Ahmadi, M., Gheibihayat, S. M., & Gholizadeh Navashenaq, J. (2021). Shedding more light on the role of Midkine in hepatocellular carcinoma: New perspectives on diagnosis and therapy. IUBMB life, 73(4), 659-669.‏

H Mosli, H., & M Attar, S. (2014). Prevalence and patterns of thyroid dysfunction in patients with rheumatoid arthritis. The Open Endocrinology Journal, 7(1).‏

Hennessey, J. V. (2015). Historical and current perspective in the use of thyroid extracts for the treatment of hypothyroidism. Endocrine practice, 21(10), 1161-1170.‏

Kabra, R., & Fisher, M. (2022). Abnormal uterine bleeding in adolescents. Current Problems in Pediatric and Adolescent Health Care, 101185.‏

Khizroeva, J., Nalli, C., Bitsadze, V., Lojacono, A., Zatti, S., Andreoli, L., ... & Makatsariya, A. (2019). Infertility in women with systemic autoimmune diseases. Best Practice & Research Clinical Endocrinology & Metabolism, 33(6), 101369.‏

Krassas, G. E., & Markou, K. B. (2019). The impact of thyroid diseases starting from birth on reproductive function. Hormones, 18(4), 365-381.‏

Kravets, I. (2016). Hyperthyroidism: diagnosis and treatment. American family physician, 93(5), 363-370.‏

Livingston, E. H. (2019). Subclinical hypothyroidism. Jama, 322(2), 180-180.‏

Meng, Z., Liu, M., Zhang, Q., Liu, L., Song, K., Tan, J., ... & Zhang, J. (2015). Gender and age impacts on the association between thyroid function and metabolic syndrome in Chinese. Medicine, 94(50).‏

Miharja, M. ., Setiawati, S. ., & Lubis, A. L. P. . (2020). How dangerous the Indonesian recession due to COVID-19 pandemic: review policy and strategy to recovery. International Journal of Social Sciences and Humanities, 4(3), 121–129. https://doi.org/10.29332/ijssh.v4n3.470

Mohammadi, S., Dolatshahi, M., & Rahmani, F. (2021). Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors. Journal of Endocrinological Investigation, 44(1), 1-13.‏

Nazarpour, S., Tehrani, F. R., Simbar, M., & Azizi, F. (2015). Thyroid dysfunction and pregnancy outcomes. Iranian journal of reproductive medicine, 13(7), 387.‏

Schellack, N., Schellack, G., & Esterhuizen, A. (2020). Shifting the paradigm in the management of conditions affecting the thyroid gland. Journal of Endocrinology, Metabolism and Diabetes of South Africa, 25(1), 28-34.‏

Seviyeleri, P. H. S. M. (2020). Serum Midkine Levels in Patients with Psoriasis. Turkiye Klinikleri J Dermatol, 30(1), 1-5.‏

Sheriba, N. A., Mahdy, M. M., Elattary, R. H. I., & El-Nabarawy, M. M. (2019). Assessment of serum midkine level in benign and malignant thyroid nodules. Can midkine be a marker of thyroid malignancy?. Thyroid Research and Practice, 16(3), 95.‏

Stahlman, S., & Oh, G. T. (2018). Thyroid disorders, active component, US Armed Forces, 2008-2017. MSMR, 25(12), 2-9.‏

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

Wang, W., Chang, J., Jia, B., & Liu, J. (2020). The blood biomarkers of thyroid cancer. Cancer Management and Research, 12, 5431.‏

Yadav, N. K., Thanpari, C., Shrewastwa, M. K., Sathian, B., & Mittal, R. K. (2013). Socio demographic wise risk assessment of thyroid function abnormalities in far western region of Nepal: A hospital based descriptive study. Asian pacific journal of tropical disease, 3(2), 150-154.‏

Zhang, D., Ding, L., Li, Y., Ren, J., Shi, G., Wang, Y., ... & Hou, Y. (2017). Midkine derived from cancer-associated fibroblasts promotes cisplatin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells. Scientific reports, 7(1), 1-11.‏