Evaluation of antiulcer, antioxidant potency of manuka honey and cinnamon powder mixture in Wistar rats using experimental rat models

Saumya Das; Veena D. Singh; Amit Bind; Anamika Anamika; Satya Prakash Gupta; Roshan Kumar

doi:10.53730/ijhs.v6nS6.10979

Authors

Saumya Das Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area Greater Noida- 201306 Uttar Pradesh, India
Veena D. Singh Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area Greater Noida- 201306 Uttar Pradesh, India
Amit Bind
bindamit04@gmail.com
Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area Greater Noida- 201306 Uttar Pradesh, India
Anamika Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-II, Institutional Area Greater Noida- 201306 Uttar Pradesh, India
Satya Prakash Gupta Sardar Patel Post Graduate Institute of Dental and Medical Science Lucknow, Uttar Pradesh, India
Roshan Kumar Dev Bhoomi Institute of Pharmacy and Research, Dehradun, Uttarakhand, India

Keywords:

antioxidant, gastrointestinal, natural active component, complementary drug, rodent animal

Abstract

Inflammation of the lining of the stomach is one of the most prevalent health problems that people face. In this study, the effects of herbal medication on the digestive system were examined in relation to the use of the cold-water immersion technique. Material & Methods: Male albino 6-week-old albino rats weighing 200-250 g each were used in the investigation. For three months, the animals were housed in the animal facility of the NIET Pharmacy Institute at 20°C (3°C) and 50-60% relative humidity. Researchers discovered non-lethal cold-water immersion in a small sample of six rats that caused stomach ulcers. After an 18-hour fasting, rats were immersed in ice-cold water. Researchers were able to examine the mucosa by isolating the stomach of rats. Result: In a model of cold-water immersion, honey has a unique effect on ulcer severity. esomeprazole is a medication used to treat acid reflux. According to phytochemical screening, the presence of flavonoids, triterpenes, and the anti-oxidant capacity of the crude drug mixture enhances antioxidant status and promotes mucus production. These elements may be responsible for the protective effect on stomach ulcer treatment. Conclusion: The content of flavonoids and triterpenes of honey and cinnamon powder mixture should be analyzed.

Downloads

Download data is not yet available.

References

H. P. Rang, Pharmacology, Churchill Livingstone, Edinburgh, UK, 2003.

K. R. DeVault and N. J. Talley, “Insights into the future of gastric acid suppression,” Nature Reviews Gastroenterology and Hepatology, vol. 6, no. 9, pp. 524–532, 2009.

K. S. Mota, G. E. N. Dias, M. E. F. Pinto et al., “Flavonoids with gastroprotective activity,” Molecules, vol. 14, no. 3, pp. 979–1012, 2009.

Kusumawati, A. H., Wulan, I. R., & Ridwanuloh, D. (2020). Formulation and physical evaluation sheet mask from red rice (Oryza Nivara) and virgin coconut oil (Cocos Nucifera L). International Journal of Health & Medical Sciences, 3(1), 60-64. https://doi.org/10.31295/ijhms.v3n1.148

M. C. Brucker and M. A. Faucher, “Pharmacologic management of common gastrointestinal health problems in women,” Journal of Nurse-Midwifery, vol. 42, no. 3, pp. 145–162, 1997.

P. Arda-Pirincci, S. Bolkent, and R. Yanardag, “The role of zinc sulfate and metallothionein in protection against ethanolic induced gastric damage in rats,” Digestive Diseases and Sciences, vol. 51, no. 12, pp. 2353–2360, 2006.

S. Patel and S. Cichello, “Manuka honey: an emerging natural food with medicinal use,” Natural Products and Bioprospecting, vol. 3, pp. 121–128, 2013.

S. W. Park, T. Y. Oh, Y. S. Kim et al., “Artemisia asiatica extracts protect against Cold water injury in gastric mucosa of rats,” Journal of Gastroenterology and Hepatology, vol. 23, no. 6, pp. 976–984, 2008.

S.-H. Chen, Y.-C. Liang, J. C. J. Chao et al., “Protective effects of Ginkgo biloba extract on the Coldwater gastric ulcer in rats,” World Journal of Gastroenterology, vol. 11, no. 24, pp. 3746– 3750, 2005. [5] S. I. Abdelwahab, M. M. E. Taha, M. A. Abdulla et al., “Gastroprotective mechanism of Bauhinia thonningii Schum,” Journal of Ethnopharmacology, vol. 148, no. 1, pp. 277–286, 2013.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Y. Du, W. Zhao, L. Lu et al., “Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced based on tumor necrosis factor-???? (TNF- ????) and endothelin-1 (ET-1),” Asian Pacific Journal of Tropical Biomedicine, vol. 3, no. 12, pp. 925–930, 2013.

Y. Kato, N. Umeda, A. Maeda, D. Matsumoto, N. Kitamoto, and H. Kikuzaki, “Identification of a novel glycoside, leptosin, as a chemical marker of manuka honey,” Journal of Agricultural and Food Chemistry, vol. 60, no. 13, pp. 3418–3423, 2012.