The incidence of myocarditis and pericarditis in post COVID-19 unvaccinated patients
Keywords:
acute coronary syndrome, COVID-19, myocarditis, pericarditisAbstract
Background and Aim: Viral infections have also been associated with the presence of autoimmune diseases such as systemic lupus disease, rheumatoid arthritis, and diabetes mellitus. SARS-CoV-2 gains entry into human cells by binding its spike protein to the membrane protein angiotensinconverting enzyme 2 (ACE2). It has recently been reported that the incidence of myocarditis and pericarditis is increased in COVID-19 patients during the acute illness. However; whether or not myocarditis and pericarditis after the recovery period are a part of the long COVID-19 syndrome is yet unknown. Hence, we studied the incidence of myocarditis and pericarditis in COVID-19 patients after recovering from the acute infection. Material and Methods: We retrieved records of all adult patients (age ≥ 18 years) who had a documented positive COVID-19 PCR test (n = 500) for the period of 1 year. A control group was created from a cohort of adult patients with at least one negative COVID-19 From this pool of patients, the control cohort was created by 3:1 matching of age (±2 years) and gender. Total 1000 patients in control group were selected.
Downloads
References
Pal R, Banerjee M. COVID-19 and the endocrine system: exploring the unexplored. J Endocrinol Invest. 2020;43: 1027-1031.
Lopez-Leon, S.; Wegman-Ostrosky, T.; Perelman, C.; Sepulveda, R.; Rebolledo, P.A.; Cuapio, A.; Villapol, S. More than 50 long-term effects of COVID-19: A systematic review and meta-analysis. Sci. Rep. 2021, 11, 16144. [CrossRef] [PubMed]
Raveendran, A.V.; Jayadevan, R.; Sashidharan, S. Long COVID: An overview. Diabetes Metab. Syndr. Clin. Res. Rev. 2021, 15, 869–875. [CrossRef] [PubMed]
Shuwa, H.A.; Shaw, T.N.; Knight, S.B.; Wemyss, K.; McClure, F.A.; Pearmain, L.; Prise, I.; Jagger, C.; Morgan, D.J.; Khan, S.; et al. Alterations in T and B cell function persist in convalescent COVID-19 patients. Med 2021, 2, 720–735.e4. [CrossRef] [PubMed]
McElvaney, O.J.; McEvoy, N.L.; McElvaney, O.F.; Carroll, T.P.; Murphy, M.P.; Dunlea, D.M.; Ni Choileain, O.; Clarke, J.; O’Connor, E.; Hogan, G.; et al. Characterization of the Inflammatory Response to Severe COVID-19 Illness. Am. J. Respir. Crit. Care Med. 2020, 202, 812–821. [CrossRef]
Tang, N.; Li, D.; Wang, X.; Sun, Z. Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J. Thromb. Haemost. 2020, 18, 844–847. [CrossRef]
Ercolini, A.M.; Miller, S.D. The role of infections in autoimmune disease. Clin. Exp. Immunol. 2009, 155, 1–15. [CrossRef]
Yazdanpanah, N.; Rezaei, N. Autoimmune complications of COVID-19. J. Med. Virol. 2021, 94, 54–62. [CrossRef]
Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020;181:271–280.e8.
Qian Z, Travanty EA, Oko L, et al. Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus. Am J Respir Cell Mol Biol 2013;48:742–748.
Goulter AB, Goddard MJ, Allen JC, Clark KL. ACE2 gene expression is upregulated in the human failing heart. BMC Med 2004;2:19.
Guo J, Wei X, Li Q, et al. Single-cell RNA analysis on ACE2 expression provides insight into SARS-CoV-2 blood entry and heart injury. Preprint. Posted online April 2020;4 https://doi.org/10.1101/2020.03.31.20047621. medRxiv 2020.03.31.20047621.
Weiss SR. Forty years with coronaviruses. J Exp Med 2020;217:e20200537
Barda, N.; Dagan, N.; Ben-Shlomo, Y.; Kepten, E.; Waxman, J.; Ohana, R.; Hernán, M.A.; Lipsitch, M.; Kohane, I.; Netzer, D.; et al. Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting. N. Engl. J. Med. 2021, 385, 1078–1090. [CrossRef] [PubMed]
Abu Mouch S, Roguin A, Hellou E, Ishai A, Shoshan U, Mahamid L, et al. Myocarditis following COVID-19 mRNA vaccination. Vaccine. 2021;39(29):3790–3. https://doi.org/10.1016/j.vaccine.2021.05.087.
Pepe S, Gregory AT, Denniss AR. Myocarditis, pericarditis and cardiomyopathy after COVID-19 vaccination. Heart Lung Circ. 2021;30(10):1425–9. https://doi.org/10.1016/j.hlc.2021.07.011.
Hung YP, Sun KS. A case of myopericarditis with pleuritis following AstraZeneca COVID-19 vaccination. QJM. 2021. https://doi.org/10.1093/ qjmed/hcab278.
Rodríguez RM, Herraiz ATI, González MJG. Cardiogenic shock due to acute myocarditis following AZD1222 vaccine administration: a case report. IJCR. 2021;5:235. https://doi.org/10.28933/ijcr-2021-07-2605.
Lo, A.W.; Tang, N.L.; To, K.-F. How the SARS coronavirus causes disease: Host or organism? J. Pathol. 2006, 208, 142–151. [CrossRef] [PubMed]
Kyuwa, S.; Yamaguchi, K.; Toyoda, Y.; Fujiwara, K. Induction of self-reactive T cells after murine coronavirus infection. J. Virol. 1991, 65, 1789–1795. [CrossRef] [PubMed]
Peretto G, Sala S, Rizzo S, et al. Ventricular arrhythmias in myocarditis: characterization and relationships with myocardial inflammation. J Am Coll Cardiol 2020;75:1046–1057.
Late-Breaking Science Abstracts and Featured Science Abstracts From the American Heart Association’s Scientific Sessions 2020 and Late-Breaking Abstracts in Resuscitation Science From the Resuscitation Science Symposium 2020. Circulation 2020, 142, e470–e500. [CrossRef]
Montero, F.; Martínez-Barrio, J.; Serrano-Benavente, B.; González, T.; Rivera, J.; Collada, J.M.; Castrejón, I.; Álvaro-Gracia, J. Coronavirus disease 2019 (COVID-19) in autoimmune and inflammatory conditions: Clinical characteristics of poor outcomes. Rheumatol. Int. 2020, 40, 1593–1598. [CrossRef]
Tan, C.; Zheng, X.; Sun, F.; He, J.; Shi, H.; Chen, M.; Tu, C.; Huang, Y.; Wang, Z.; Liang, Y.; et al. Hypersensitivity may be involved in severe COVID-19. Clin. Exp. Allergy 2021, 52, 324–333. [CrossRef] [PubMed]
Yu, L.; Feng, Z. The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure. Mediat. Inflamm. 2018, 2018, 9874109. [CrossRef] [PubMed]
Saad, M.A.; Alfishawy, M.; Nassar, M.; Mohamed, M.; Esene, I.N.; Elbendary, A. COVID-19 and Autoimmune Diseases: A Systematic Review of Reported Cases. Curr. Rheumatol. Rev. 2021, 17, 193–204.
Puntmann, V.O.; Carerj, M.L.; Wieters, I.; Fahim, M.; Arendt, C.; Hoffmann, J.; Shchendrygina, A.; Escher, F.; Vasa-Nicotera, M.; Zeiher, A.M.; et al. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020, 5, 1265–1273.
Xie, Y.; Xu, E.; Bowe, B.; Al-Aly, Z. Long-term cardiovascular outcomes of COVID-19. Nat. Med. 2022, 28, 583–590.
HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. ACC New Story. March 28, 2020, https://www.acc.org/latest-incardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concernsre-using-raas-antagonists-in-covid-19.
Barda, N.; Dagan, N.; Ben-Shlomo, Y.; Kepten, E.; Waxman, J.; Ohana, R.; Hernán, M.A.; Lipsitch, M.; Kohane, I.; Netzer, D.; et al. Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting. N. Engl. J. Med. 2021, 385, 1078–1090.
Intriago, C. Z., & Posligua, T. I. Q. (2020). Telecommunications and virtualization in times of pandemic: impact on the electrical engineering career. International Journal of Physical Sciences and Engineering, 4(3), 38–44. https://doi.org/10.29332/ijpse.v4n3.630
Yuliartini, N. P. R., Putra, I. B. W., Atmaja, G. M. W., & Mangku, D. G. S. (2022). The quality of health services during COVID-19 pandemic in Indonesia. International Journal of Health Sciences, 6(2), 627–638. https://doi.org/10.53730/ijhs.v6n2.7511
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.








