The incidence of myocarditis and pericarditis in post COVID-19 unvaccinated patients

https://doi.org/10.53730/ijhs.v6nS5.11049

Authors

  • Sanyamee Patel MBBS, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
  • Prashilkumar Patel MBBS, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
  • Ayushi Mehta MBBS, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
  • Ishan Patel MBBS, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India
  • Shubham Thakor MBBS, Tutor, Department of Anatomy, Smt. B. K. Shah Medical Institute & Research Centre, Waghodia, Vadodara, Gujarat, India
  • Om Lumbhani MBBS, Smt. NHL Municipal Medical College, Ahmedabad, Gujarat, India

Keywords:

acute coronary syndrome, COVID-19, myocarditis, pericarditis

Abstract

Background and Aim: Viral infections have also been associated with the presence of autoimmune diseases such as systemic lupus disease, rheumatoid arthritis, and diabetes mellitus. SARS-CoV-2 gains entry into human cells by binding its spike protein to the membrane protein angiotensinconverting enzyme 2 (ACE2). It has recently been reported that the incidence of myocarditis and pericarditis is increased in COVID-19 patients during the acute illness. However; whether or not myocarditis and pericarditis after the recovery period are a part of the long COVID-19 syndrome is yet unknown. Hence, we studied the incidence of myocarditis and pericarditis in COVID-19 patients after recovering from the acute infection. Material and Methods: We retrieved records of all adult patients (age ≥ 18 years) who had a documented positive COVID-19 PCR test (n = 500) for the period of 1 year. A control group was created from a cohort of adult patients with at least one negative COVID-19 From this pool of patients, the control cohort was created by 3:1 matching of age (±2 years) and gender. Total 1000 patients in control group were selected. 

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References

Pal R, Banerjee M. COVID-19 and the endocrine system: exploring the unexplored. J Endocrinol Invest. 2020;43: 1027-1031.

Lopez-Leon, S.; Wegman-Ostrosky, T.; Perelman, C.; Sepulveda, R.; Rebolledo, P.A.; Cuapio, A.; Villapol, S. More than 50 long-term effects of COVID-19: A systematic review and meta-analysis. Sci. Rep. 2021, 11, 16144. [CrossRef] [PubMed]

Raveendran, A.V.; Jayadevan, R.; Sashidharan, S. Long COVID: An overview. Diabetes Metab. Syndr. Clin. Res. Rev. 2021, 15, 869–875. [CrossRef] [PubMed]

Shuwa, H.A.; Shaw, T.N.; Knight, S.B.; Wemyss, K.; McClure, F.A.; Pearmain, L.; Prise, I.; Jagger, C.; Morgan, D.J.; Khan, S.; et al. Alterations in T and B cell function persist in convalescent COVID-19 patients. Med 2021, 2, 720–735.e4. [CrossRef] [PubMed]

McElvaney, O.J.; McEvoy, N.L.; McElvaney, O.F.; Carroll, T.P.; Murphy, M.P.; Dunlea, D.M.; Ni Choileain, O.; Clarke, J.; O’Connor, E.; Hogan, G.; et al. Characterization of the Inflammatory Response to Severe COVID-19 Illness. Am. J. Respir. Crit. Care Med. 2020, 202, 812–821. [CrossRef]

Tang, N.; Li, D.; Wang, X.; Sun, Z. Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J. Thromb. Haemost. 2020, 18, 844–847. [CrossRef]

Ercolini, A.M.; Miller, S.D. The role of infections in autoimmune disease. Clin. Exp. Immunol. 2009, 155, 1–15. [CrossRef]

Yazdanpanah, N.; Rezaei, N. Autoimmune complications of COVID-19. J. Med. Virol. 2021, 94, 54–62. [CrossRef]

Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020;181:271–280.e8.

Qian Z, Travanty EA, Oko L, et al. Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus. Am J Respir Cell Mol Biol 2013;48:742–748.

Goulter AB, Goddard MJ, Allen JC, Clark KL. ACE2 gene expression is upregulated in the human failing heart. BMC Med 2004;2:19.

Guo J, Wei X, Li Q, et al. Single-cell RNA analysis on ACE2 expression provides insight into SARS-CoV-2 blood entry and heart injury. Preprint. Posted online April 2020;4 https://doi.org/10.1101/2020.03.31.20047621. medRxiv 2020.03.31.20047621.

Weiss SR. Forty years with coronaviruses. J Exp Med 2020;217:e20200537

Barda, N.; Dagan, N.; Ben-Shlomo, Y.; Kepten, E.; Waxman, J.; Ohana, R.; Hernán, M.A.; Lipsitch, M.; Kohane, I.; Netzer, D.; et al. Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting. N. Engl. J. Med. 2021, 385, 1078–1090. [CrossRef] [PubMed]

Abu Mouch S, Roguin A, Hellou E, Ishai A, Shoshan U, Mahamid L, et al. Myocarditis following COVID-19 mRNA vaccination. Vaccine. 2021;39(29):3790–3. https://doi.org/10.1016/j.vaccine.2021.05.087.

Pepe S, Gregory AT, Denniss AR. Myocarditis, pericarditis and cardiomyopathy after COVID-19 vaccination. Heart Lung Circ. 2021;30(10):1425–9. https://doi.org/10.1016/j.hlc.2021.07.011.

Hung YP, Sun KS. A case of myopericarditis with pleuritis following AstraZeneca COVID-19 vaccination. QJM. 2021. https://doi.org/10.1093/ qjmed/hcab278.

Rodríguez RM, Herraiz ATI, González MJG. Cardiogenic shock due to acute myocarditis following AZD1222 vaccine administration: a case report. IJCR. 2021;5:235. https://doi.org/10.28933/ijcr-2021-07-2605.

Lo, A.W.; Tang, N.L.; To, K.-F. How the SARS coronavirus causes disease: Host or organism? J. Pathol. 2006, 208, 142–151. [CrossRef] [PubMed]

Kyuwa, S.; Yamaguchi, K.; Toyoda, Y.; Fujiwara, K. Induction of self-reactive T cells after murine coronavirus infection. J. Virol. 1991, 65, 1789–1795. [CrossRef] [PubMed]

Peretto G, Sala S, Rizzo S, et al. Ventricular arrhythmias in myocarditis: characterization and relationships with myocardial inflammation. J Am Coll Cardiol 2020;75:1046–1057.

Late-Breaking Science Abstracts and Featured Science Abstracts From the American Heart Association’s Scientific Sessions 2020 and Late-Breaking Abstracts in Resuscitation Science From the Resuscitation Science Symposium 2020. Circulation 2020, 142, e470–e500. [CrossRef]

Montero, F.; Martínez-Barrio, J.; Serrano-Benavente, B.; González, T.; Rivera, J.; Collada, J.M.; Castrejón, I.; Álvaro-Gracia, J. Coronavirus disease 2019 (COVID-19) in autoimmune and inflammatory conditions: Clinical characteristics of poor outcomes. Rheumatol. Int. 2020, 40, 1593–1598. [CrossRef]

Tan, C.; Zheng, X.; Sun, F.; He, J.; Shi, H.; Chen, M.; Tu, C.; Huang, Y.; Wang, Z.; Liang, Y.; et al. Hypersensitivity may be involved in severe COVID-19. Clin. Exp. Allergy 2021, 52, 324–333. [CrossRef] [PubMed]

Yu, L.; Feng, Z. The Role of Toll-Like Receptor Signaling in the Progression of Heart Failure. Mediat. Inflamm. 2018, 2018, 9874109. [CrossRef] [PubMed]

Saad, M.A.; Alfishawy, M.; Nassar, M.; Mohamed, M.; Esene, I.N.; Elbendary, A. COVID-19 and Autoimmune Diseases: A Systematic Review of Reported Cases. Curr. Rheumatol. Rev. 2021, 17, 193–204.

Puntmann, V.O.; Carerj, M.L.; Wieters, I.; Fahim, M.; Arendt, C.; Hoffmann, J.; Shchendrygina, A.; Escher, F.; Vasa-Nicotera, M.; Zeiher, A.M.; et al. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020, 5, 1265–1273.

Xie, Y.; Xu, E.; Bowe, B.; Al-Aly, Z. Long-term cardiovascular outcomes of COVID-19. Nat. Med. 2022, 28, 583–590.

HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19. ACC New Story. March 28, 2020, https://www.acc.org/latest-incardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concernsre-using-raas-antagonists-in-covid-19.

Barda, N.; Dagan, N.; Ben-Shlomo, Y.; Kepten, E.; Waxman, J.; Ohana, R.; Hernán, M.A.; Lipsitch, M.; Kohane, I.; Netzer, D.; et al. Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting. N. Engl. J. Med. 2021, 385, 1078–1090.

Intriago, C. Z., & Posligua, T. I. Q. (2020). Telecommunications and virtualization in times of pandemic: impact on the electrical engineering career. International Journal of Physical Sciences and Engineering, 4(3), 38–44. https://doi.org/10.29332/ijpse.v4n3.630

Yuliartini, N. P. R., Putra, I. B. W., Atmaja, G. M. W., & Mangku, D. G. S. (2022). The quality of health services during COVID-19 pandemic in Indonesia. International Journal of Health Sciences, 6(2), 627–638. https://doi.org/10.53730/ijhs.v6n2.7511

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937

Published

31-07-2022

How to Cite

Patel, S., Patel, P., Mehta, A., Patel, I., Thakor, S., & Lumbhani, O. (2022). The incidence of myocarditis and pericarditis in post COVID-19 unvaccinated patients. International Journal of Health Sciences, 6(S5), 11743–11751. https://doi.org/10.53730/ijhs.v6nS5.11049

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Section

Peer Review Articles