Biofilm aggravates antibiotic resistance
Molecular mechanisms behind
Keywords:
biofilm, planktonic cells, group behavior, drug resistanceAbstract
It is possible for a variety of bacteria, including pathogens, to form biofilms, which serve as a mechanism for these organisms to defend themselves against antimicrobial agents in the environment.In order to explain this phenomenon of resistance within biofilms, several mechanisms have been proposed.These include delayed penetration of the antimicrobial into the biofilm extracellular matrix, slowing of the growth rate of organisms within the biofilm, and other physiologic changes brought about by interaction of the organisms with a surface.The existence of bacteria within a self-produced polymeric matrix, known as a biofilm, is another old survival strategy that is still used to this day. Biofilms, in a similar way, enable bacteria to adapt to their environment and promote the transfer of antibiotic resistance genes between different bacterial species.Because of its ability to spread antibiotic resistance genes as well as its innate phenotypic tolerance to antibiotics, biofilm must be considered synonymous with antibiotic resistance. Despite the fact that environmental biofilm does not fall under the current definition of antimicrobial stewardship, increased awareness of the existence, prevalence, and consequences of environmental biofilm among healthcare practitioners is critical to improving hygiene practises and preventing the emergence and spread of antibiotic resistance in healthcare facilities.
Downloads
References
Admassie M. Current review on molecular and phenotypic mechanism of bacterial resistance to antibiotic. Sci J Clin Med. 2018 May 8;7:13.
Aeschlimann JR. The role of multidrug efflux pumps in the antibiotic resistance of Pseudomonas aeruginosa and other gram‐negative bacteria: insights from the Society of Infectious Diseases Pharmacists. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2003 Jul;23(7):916-24.
Alamsyah, T., Marianthi, D., Hayati, W., & Usrina, N. (2021). Drug user behavior about the development and rehabilitation process in Banda Aceh correctional institution. International Journal of Health & Medical Sciences, 4(1), 88-94. https://doi.org/10.31295/ijhms.v4n1.1348
Bagge AM, Sasal P, Valtonen ET, Karvonen A. Infracommunity level aggregation in the monogenean communities of crucian carp (Carassius carassius). Parasitology. 2005 Sep;131(3):367-72.
Bisht K, Wakeman CA. Discovery and therapeutic targeting of differentiated biofilm subpopulations. Frontiers in Microbiology. 2019:1908.
Borges A, Abreu AC, Dias C, Saavedra MJ, Borges F, Simões M. New perspectives on the use of phytochemicals as an emergent strategy to control bacterial infections including biofilms. Molecules. 2016 Jul;21(7):877.
Brauner A, Fridman O, Gefen O, Balaban NQ. Distinguishing between resistance, tolerance and persistence to antibiotic treatment. Nature Reviews Microbiology. 2016 May;14(5):320-30.
Cepas V, López Y, Muñoz E, Rolo D, Ardanuy C, Martí S, Xercavins M, Horcajada JP, Bosch J, Soto SM. Relationship between biofilm formation and antimicrobial resistance in gram-negative bacteria. Microbial Drug Resistance. 2019 Jan 1;25(1):72-9.
Constantinescu CS, Farooqi N, O'Brien K, Gran B. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). British journal of pharmacology. 2011 Oct;164(4):1079-106.
Dewasthale S, Mani I, Vasdev K. Microbial biofilm: current challenges in health care industry. J Appl Biotechnol Bioeng. 2018;5(3):160-4.
Dincer S, Uslu FM, Delik A. Antibiotic resistance in biofilm. InBacterial biofilms 2020 May 12. IntechOpen.
Dincer S, Uslu FM, Delik A. Antibiotic resistance in biofilm. InBacterial biofilms 2020 May 12. IntechOpen.
Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clinical microbiology reviews. 2002 Apr;15(2):167-93.
Donlan RM. Role of biofilms in antimicrobial resistance. ASAIO journal. 2000 Nov 1;46(6):S47-52.
Evans WC. Trease and evans. Pharmacognosy, 9th Edition published by Saunders Elsevier. 2002;553.
Grant CA, Clarke JM, Duguid S, Chaney RL. Selection and breeding of plant cultivars to minimize cadmium accumulation. Science of the total environment. 2008 Feb 15;390(2-3):301-10.
Grkovic S, Brown MH, Skurray RA. Transcriptional regulation of multidrug efflux pumps in bacteria. InSeminars in cell & developmental biology 2001 Jun 1 (Vol. 12, No. 3, pp. 225-237). Academic Press.
Hall CW, Mah TF. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS microbiology reviews. 2017 May 1;41(3):276-301.
Hall CW, Mah TF. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS microbiology reviews. 2017 May 1;41(3):276-301.
Hall CW, Mah TF. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS microbiology reviews. 2017 May 1;41(3):276-301.
Harms A, Maisonneuve E, Gerdes K. Mechanisms of bacterial persistence during stress and antibiotic exposure. Science. 2016 Dec 16;354(6318):aaf4268.
Hobbs JK, Boraston AB. (p) ppGpp and the stringent response: an emerging threat to antibiotic therapy. ACS infectious diseases. 2019 Jul 9;5(9):1505-17.
Høiby N, Bjarnsholt T, Givskov M, Molin S, Ciofu O. Antibiotic resistance of bacterial biofilms. International journal of antimicrobial agents. 2010 Apr 1;35(4):322-32.
Jolivet-Gougeon A, Bonnaure-Mallet M. Biofilms as a mechanism of bacterial resistance. Drug Discovery Today: Technologies. 2014 Mar 1;11:49-56.
Kassahn KS, Crozier RH, Pörtner HO, Caley MJ. Animal performance and stress: responses and tolerance limits at different levels of biological organisation. Biological Reviews. 2009 May;84(2):277-92.
Kornelsen V, Kumar A. Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp. Antimicrobial Agents and Chemotherapy. 2021 Jul 1;65(7):e00514-21.
Kostakioti M, Hadjifrangiskou M, Hultgren SJ. Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harbor perspectives in medicine. 2013 Apr 1;3(4):a010306.
Lee KY, Lee BJ. Structure, biology, and therapeutic application of toxin–antitoxin systems in pathogenic bacteria. Toxins. 2016 Oct;8(10):305.
Maquelin K, Kirschner C, Choo-Smith LP, van den Braak N, Endtz HP, Naumann D, Puppels GJ. Identification of medically relevant microorganisms by vibrational spectroscopy. Journal of microbiological methods. 2002 Nov 1;51(3):255-71.
Mishina Y, Duguid EM, He C. Direct reversal of DNA alkylation damage. Chemical reviews. 2006 Feb 8;106(2):215-32.
Poole K. Stress responses as determinants of antimicrobial resistance in Gram-negative bacteria. Trends in microbiology. 2012 May 1;20(5):227-34.
Singh S, Singh SK, Chowdhury I, Singh R. Understanding the mechanism of bacterial biofilms resistance to antimicrobial agents. The open microbiology journal. 2017;11:53.
Soto SM. Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm. Virulence. 2013 Apr 1;4(3):223-9.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
Tseng BS, Zhang W, Harrison JJ, Quach TP, Song JL, Penterman J, Singh PK, Chopp DL, Packman AI, Parsek MR. The extracellular matrix protects P seudomonas aeruginosa biofilms by limiting the penetration of tobramycin. Environmental microbiology. 2013 Oct;15(10):2865-78.
Vasudevan R. Biofilms: microbial cities of scientific significance. J Microbiol Exp. 2014 Jun;1(3):00014.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
