Evaluation of interleukin 6 (il-6) levels among Iraqi rheumatoid arthritis patients
Keywords:
(IL-6), RA, ELISAAbstract
Rheumatoid arthritis (RA) is complex autoimmune system disease and significant impact on the health of population in our world. Numerous studies confirmed that genetic factors play a crucial role in the pathogenesis of RA. Interleukin-6 (IL-6) is a common pro-inflammatory cytokine with various functions in different pathophysiologic systems, especially in the development of RA. The Interleukin-6 (IL-6)is affected by common, functionally important genetic polymorphisms. Serum Interleukin-6 (IL-6) levels were higher in rheumatoid arthritis subjects than in nonrheumatoid arthritis subjects. (IL-6) may be a potential biomarker in rheumatoid arthritis (IL-6) concentrations in sera were measured by "enzyme-linked immunosorbent assay (ELISA)" technique using Human-Interleukin-6(Bioassay Technology Laboratory). The results of the present study demonstrate that highly significant differences. The aim of this study is to evaluate serum levels of IL-6 among Iraqi RA patients. the IL-6levels in the rheumatoid arthritis patients were higher than that of controls (126.6436± 30.63222), controls (119.0229 ± 54.50154), P= 0.899. It is noteworthy that the (IL-6) levels in the current study were IL-6 levels were higher in males than in females when comparing male patients with female patients (181.7823±117.92967versus 110.4356±34.83798), P= 0.558.We conclude that there may be a correlation between high levels of (IL-6) and rheumatoid arthritis.
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• Hen .J, Zhang. A, Yang .Y, Si .Y, Hao. D.( 2021). Assessment of interleukin 6 gene polymorphisms with rheumatoid arthritis. Gene. Jan 10;765:145070.
• Schotte, H., Schmidt, H., Gaubitz, M., Drynda, S., Kekow, J., Willeke, P., & Schlüter, B. (2015). Interleukin-6 promoter haplotypes are associated with etanercept response in patients with rheumatoid arthritis. Clinical rheumatology, 34(12), 2021-2028.
• Li, B., Xiao, Y., Xing, D., Ma, X. L., & Liu, J. (2016). Circulating interleukin-6 and rheumatoid arthritis: a Mendelian randomization meta-analysis. Medicine, 95(23).
• Gaber, W., Azkalany, G. S., Gheita, T. A., Mohey, A., & Sabry, R. (2013). Clinical significance of serum interleukin-6 and− 174 G/C promoter polymorphism in Rheumatoid arthritis patients. The Egyptian Rheumatologist, 35(2), 107-113.
• Nile, C. J., Read, R. C., Akil, M., Duff, G. W., & Wilson, A. G. (2008). Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis. Arthritis & Rheumatism, 58(9), 2686-2693.
• Chung, S. J., Kwon, Y. J., Park, M. C., Park, Y. B., & Lee, S. K. (2011). The correlation between increased serum concentrations of interleukin-6 family cytokines and disease activity in rheumatoid arthritis patients. Yonsei medical journal, 52(1), 113-120.
• Brandão, F. M., Coelho, P., Pinto, P., & Combe, B. (2010). Tocilizumab-a new step in rheumatoid arthritis treatment. Acta Reumatologica Portuguesa, 35(3), 302-312.
• Panoulas, V. F., Stavropoulos-Kalinoglou, A., Metsios, G. S., Smith, J. P., Milionis, H. J., Douglas, K. M., ... & Kitas, G. D. (2009). Association of interleukin-6 (IL-6)-174G/C gene polymorphism with cardiovascular disease in patients with rheumatoid arthritis: the role of obesity and smoking. Atherosclerosis, 204(1), 178-183.
• Brozik, M., Rosztoczy, I., Meretey, K., Balint, G., Gaal, M., Balogh, Z., ... & Falus, A. (1992). Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production. The Journal of Rheumatology, 19(1), 63-68.
• Houssiau, F. A., Devogelaer, J. P., Damme, J. V., Deuxchaisnes, C. N. D., & Snick, J. V. (1988). Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 31(6), 784-788.
• Sawada, T., Hirohata, S., Inoue, T., & Ito, K. (1991). Correlation between rheumatoid factor and IL-6 activity in synovial fluids from patients with rheumatoid arthritis. Clinical and experimental rheumatology, 9(4), 363-368.
• Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949
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