Status of vitamin D level in newly diagnosed pemphigus vulgaris patients
A case–control study from tertiary care centre of Eastern India
Keywords:
Pemphigus vulgaris, Vitamin D, Calcitriol, Autoimmune diseaseAbstract
Background: Pemphigus vulgaris (PV), one common type of pemphigus, that affects the skin and mucous membranes, produce keratinocyte acantholysis by desmoglein-3 autoantibodies. Many medical conditions, including autoimmune illnesses, have been linked to vitamin D deficiency. Aim of study: To measure vitamin D level of Pemphigus Vulgaris patients and compare that with healthy controls& severity of disease. Material and Methods: Newly diagnosed PV patients (44) were compared to 50 healthy controls in this case-control study on vitamin D levels. At S.C.B. Medical College & Hospital, Odisha, the dermatology department chose all patients over a two-year period (2017-2019). Pemphigus vulgaris lesion severity ratings were used to measure the disease severity. The 25(OH) D levels in the blood were determined using the ECLIA method (Electro chemiluminescence immunoassay) in Cobas e411 analyzer. Analyses of the data included independent t-tests and pearson correlations. Results: Gender, age, and other characteristics of both groups were virtually identical. The study comprised 44 patients (27 females and 17 males) and 50 controls (including 19 men and 31 women). Eighty-six percent of patients had moderate to severe involvement, whereas 11% had minor lesions. Patients had Vitamin D levels of 14.44±9.03, compared to 32.88±15.66 for controls (p<0.05).
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