Estimation of serum homocysteine & lipid profile in chronic kidney disease patients
Keywords:
Chronic Kidney Disease, Homocysteine, Lipid ProfileAbstract
Background: Chronic kidney disease (CKD) is a deterioration of renal function, which results from diminished effective functioning of renal tissue. CKD is associated with dyslipidemia associating hypertriglyceridemia, elevated LDL cholesterol, an accumulation of apolipoprotein B (Apo B) containing lipoproteins, increased concentrations of lipoprotein(a) particles, and low HDL levels. Homocystein is considered as a risk or pathogenic factor in the progression of CKD which has been considered globally as a serious health issue. Aim & Objective: To estimate and compare the levels of serum homocysteine & lipid profile between chronic kidney disease patients and healthy individuals. Materials & Methods: The present case control study was conducted at Dhiraj General hospital, Piparia, Vadodara, Gujarat, India in which 100 age and sex matched subjects were enrolled, out of which 50 were cases of CKD patients and 50 were controls. Approximately 5 ml of fasting blood sample was drawn from the each person with aseptic precautions. Serum was separated which was used for the estimation of serum homocysteine, lipid profile, serum creatinine and blood urea.
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