Natural bioactives in the management of hyperuricemia
A challenge to gout therapy
Keywords:
hyperuricemia, gout, bioactives, serum uric acid, xanthine oxidaseAbstract
Hyperuricemia, also known as gout, has been identified as a well-known metabolic disorder associated with an elevated uric acid level in serum. Gout is commonly associated with various chronic disorders like hypertension, obesity, hyperlipidemia, cardiovascular disorders, and diabetes. Drugs, like nonsteroidal anti-inflammatory medications [NSAIDs] and glucocorticoids, are shown to exhibit serious side effects, when used in this therapy, although they are the first-line of treatment options available to date. Bioactive compounds have been explored for the management of hyperuricemia for their effectiveness and ability to minimize complications. Related research have reported the use of plant-based bioactives on hyperuricemia. The objective of the present review is to highlight the therapeutic effect of the naturally occurring phytochemicals and the pharmacology of the compounds involved in the same. These phytochemicals are categorized into five classes, namely alkaloids, flavonoids, saponins, and phenolic acids, that describe their anti-gout activity. Additionally, the mechanism of action by which these bioactive compounds display the hypouricemic consequences has been divided into three parts, namely, the inhibition of the production of uric acid, lowering of intestinal uric acid secretion, and enhancement of elimination of renal uric acid.
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