Biochemical and molecular study in diabetic infertile males

K. Ranjith Babu; Manibalan Vijayaraman; Deepti Shastri; E. Manivannan

doi:10.53730/ijhs.v6nS5.11364

Authors

K. Ranjith Babu
drranjithbabu@gmail.com
Ph.D. Scholar, Vinayaka Mission’s Research Foundation, Salem, Tamilnadu, INDIA.
Manibalan Vijayaraman Associate Professor of Physiology, Vinayaka Mission’s Medical College, Karaikal, Tamilnadu, INDIA
Deepti Shastri Professor of Anatomy, Vinayaka Mission’s Kirupananda Variyar Medical College, Salem, Tamilnadu, INDIA
E. Manivannan Professor of Pharmacology, Vinayaka Mission’s Kirupananda Variyar Medical College, Salem, Tamilnadu, INDIA

Keywords:

Diabetic infertile, biochemical, semen analysis, FSH, LH, FBS, Prolactin, Testosterone, MTHFR

Abstract

As per the statement by World Health Organization, Infertility is presence of a medical condition of the couple with inability in getting conceived for 1 year or more without usage of any contraception. In the present situation, the incidence of Infertility has increased and it is viewed as a major concern with affecting about 15% to 20% of the couples. A detailed systematic examination of history, investigative protocol is necessary for proper management of infertility. The patients were also advised for blood hormonal analysis tests such as Follicle Stimulation Hormone (FSH), Testosterone, Luteinizing Hormone (LH), Prolactin. Methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the key enzymes in folate metabolism. The enzyme activities of MTHFR and MTRR are influenced by gene polymorphisms. So the polymorphisms of MTHFR and MTRR may be a potential risk factor for male infertility. The present study was done in 100 males, 50 diabetic infertile and 50 non-diabetic fertile men. Semen samples were obtained and analyzed as per the instructions given in the WHO manual for semen analysis [10]. A blood sample was collected and analyzed for the levels of FBS, FSH, LH, Prolactin and Testosterone.

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