Potential oncogenic role of human cytomegalovirus in colorectal cancer

Heba F. Hassan; Basim Mohammed Khashman; Hujaz Ismail Abdulrazzaq Alqirbi

doi:10.53730/ijhs.v6nS6.11459

Authors

Heba F. Hassan Department of Basic Sciences. College of Dentistry. University of Baghdad, Iraq
Basim Mohammed Khashman
basim@bccru.uobaghdad.edu.iq
National cancer research center (NCRC), University of Baghdad, Iraq
Hujaz Ismail Abdulrazzaq Alqirbi Department of Microbiology, Al-kindy College of Medicine, Baghdad University, Iraq

Keywords:

CMV, CRC, HDAC3, IHC, oncogenesis

Abstract

Aims: This study was conducted to investigate whether there is a link between HDAC3 expression and clinical characteristics in colorectal cancer (CRC) patients and to detect the oncopotenial role of HCMV in colorectal cancer (CRC). Material and methods: 30 samples of formalin fixed-Paraffin embedded archival tissues were collected from patient suffering of CRC , In addition to 10 samples of free cancer tissue for determine of expression of HDAC3 and CMV by using immunohistochemistry. Results: HDAC3 expression by Immunohisto-chemical (IHC) staining was found in 19 samples (63. 3%) of CRC. While There is no expression of CMV in all samples of CRC and control groups. Conclusion: This study proved HDAC3 expression pattern in CRC, and the findings support HDAC3 as a supplementary marker to known histopathological diagnostic components; it could potentially be used in prognosis and targeted therapy. We also found that there is no correlation of the CMV infection and CRC as a pro-tumorigenic factor.

Downloads

Download data is not yet available.

References

Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA: Cancer J Clin. 2014;64(1):9–29.

Ferlay J, Soerjomataram I, Dikshit R, et al. 2015.Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer.;136(5):E359–386.

World Health Organization. Early detection of cancers common in the Eastern Mediterranean Region. (2018).

Brenner, H.; Kloor, M. & Pox, CP. Colorectal cancer. (2014). Lancet., 383: 14901502..

Soreide K, Nedrebo BS, Knapp JC, Glomsaker TB, Soreide JA, Korner H. Evolving molecular classification by genomic and proteomic biomarkers in colorectal cancer.(2009): Potential implications for the surgical oncologist. Surg Oncology;18(1):31–50.

Sabine Becke, Ve´ ronique Fabre-Mersseman, Steffi Aue, Sabrina Auerochs, Tina Sedmak, UweWolfrum, Dennis Strand, Manfred Marschall, BodoPlachter and Sabine Reyda.( 2010). Modification of the major tegument protein pp65 of human cytomegalovirus inhibits virus growth and leads to the enhancement of a protein complex with pUL69 and pUL97 in infected cells. Journal of General Virology; 91(): DOI 10.1099/vir.0.022293-0 022293 G.

Kalejta RF.(2008)Functions of human cytomegalovirus tegument proteins prior to immediate early gene expression. Curr Top MicrobiolImmunol,325:101- 116.

Martin Michaelis, Hans W. Doerr and JindrichCinatlJr.(2009). The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions. Neoplasia; 11(1): .

Basim Mohammed Khashman.(2017).Study the Oncomodulation Potential of Human Cytomegalovirus and its Correlation with TGF-β1 in a Group of Iraqi Patients with OSCC. International Journal of Science and Research (IJSR), Volume 6 Issue 5.

Marongiu L. and Allgayer H(2022) Viruses in colorectal cancer. REVIEW. Molecular Oncology 16 1423–1450.

Chiopris G, Veronese P, Cusenza F, Procaccianti M, Perrone S, Dacco V, Colombo C & Esposito S . (2020).Congenital cytomegalovirus infection: update on diagnosis and treatment. Microorganisms. 8, 1516.

Britt W . (2008) . Manifestations of human cytomegalovirus infection: proposed mechanisms of acute and chronic disease. Curr Topic Microbiol Immunol 325, 417–470.

Cobbs C . (2019) .Cytomegalovirus is a tumor-associated virus: armed and dangerous. Curr Opin Virol. 39, 49–59.

Huang E & Roche J. (1978) . Cytomegalovirus D.N.A. and adenocarcinoma of the colon: evidence for latent viral infection. Lancet 1, 957–960.

Basim M. Khashman, Suhad K. Karim and Ghada Nazar Al-Jussani.(2020). The oncogenic effect of EBV/HPV co infection in group of Iraqi women with cervical carcinoma. Biochemical and Cellular Archives, 20(2), pp. 6037–6040.

Machery, E. (2012). Power and Negative Results. Philosophy of Science, 79(5), 808–820. https://doi.org/10.1086/667877.

Jiang Y, Hsieh J.(2014). HDAC3 controls gap 2/mitosis progression in adult neural stem/progenitor cells by regulating CDK1 levels. Proc NatlAcad Sci U S A.;111(37):13541–1356.

La Rosa, C., & Diamond, D. J. (2012). The immune response to human CMV. Future virology, 7(3), 279–293. https://doi.org/10.2217/fvl.12.8

Akintola-Ogunremi O, Luo Q, He T & Wang H (2005). Is cytomegalovirus associated with human colorectal tumorigenesis? Am J Clin Pathol 123, 244–249.

B, Wang X, Chen E & Zhu H .(2016). Human cytomegalovirus infection and colorectal cancer risk: a meta-analysis. Oncotarget 7, 76735–76742.

Chen H, Jiang J, Chen C, Chou T, Chen Y, Chang Y, Lin S, Chan C, Yang C, Lin C-H et al. (2012) . Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: a quantitative and histological analysis. J Clin Virol 54, 240–244.

Bender C, Zipeto D, Bidoia C, Costantini S, Zamo A, Menestrina F & Bertazzoni U .(2009) Analysis of colorectal cancers for human cytomegalovirus presence. Infect Agent Cancer 4, 6.