Effects of chemotherapy on antioxidant enzymes activities and lipid peroxide levels in the blood of women with breast cancer

Raghad Obead AbdulAL-Abass; Hadi Sajid Abdulabbas; Yasir Haider Al-Mawlah; Mohammed Abdullah Jebor

doi:10.53730/ijhs.v6nS7.11497

Authors

Raghad Obead AbdulAL-Abass Department of Nursing, Al-Mustaqbal University College, Babylon, 51001, Iraq.
Hadi Sajid Abdulabbas Continuous Education Department, Faculty of Dentistry, University of Al-Ameed, Karbala, 56001, Iraq.
Yasir Haider Al-Mawlah 3DNA Research Center, University of Babylon, Babylon, Hillah-Najaf Street, 51001, Iraq.
Mohammed Abdullah Jebor Department of Biology, College of Sciences, Babylon University, Babylon, 51001, Iraq.

Keywords:

Breast Cancer, Antioxidant Enzyme, Chemotherapy

Abstract

Breast cancer is the most frequent cancer among women around the world. Various studies have looked into the causes of that cancer in order to find a technique to diagnose it early and treat it effectively. The current study investigated the relationship between the decrease of an antioxidant enzyme among breast cancer patients and the effect of chemotherapy on it. This study investigated the relationship between the reduction of antioxidant enzymes and the effect of chemotherapy in breast cancer patients. The survey was conducted on 70 histopathologically diagnosed breast cancer patients (all women) from the Babylon Mirjan Medical City Oncology Centre, with 30 apparently healthy women serving as controls. The current study found differences in some biochemical markers between controls and cases with breast cancer. The Superoxide dismutase (SOD) activity in the control was (64.4023.76) U/ml, while its activity in the case was significantly decreased to reach (9.516.59) U/ml in the first group (1–5 doses) and (9.254.62) U/ml in the second group (6–10), and the GSH concentration in the control was (17.579.09), whereas its activity in the case was significantly reduced to reach (2.070.88) umol/ml in the first group (1–5), (2.341.65).

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