To study the estrogen (ER) and progesterone (PR) receptor in case of primary and metastatic breast cancer

Parul Rao; Ravikant Ravikant; Srishti Soni; Davendra Kumar Singh

doi:10.53730/ijhs.v6nS8.11577

Authors

Parul Rao Associate Professor, Department of Pathology, K D Medical College and Research Centre, Akbarpur, Mathura, UP
Ravikant Assistant Professor, Department of Orthopedics, SN Medical College, Agra, UP
Srishti Soni Associate Professor, Department of Pathology, GMC, Orai, Jalaun, UP
Davendra Kumar Singh
dr_priyasingh@rediffmail.com
Professor & Head, Department of Respiratory Medicine, School of Medical Science & Research, Sharda University Gautam Budh Nagar, UP India 201306

Keywords:

estrogen receptor, progesterone receptor, immunocytochemistry, breast carcinoma

Abstract

Background: Worldwide, breast cancer is the most common invasive cancer in women.It comprises 22.9% of invasive cancers in women and 16% of all female cancers. It accounts for 15% of cancer deaths worldwide.Objective: to study the expression of ER/PR on breast cancer by immunocytochemistry on fine needle aspiration smears. Material and Methods: A prospective study was carried out on 120 cases of breast lump, referred from various clinical Departments to cytopathology lab of a tertiary care center in North India, during September 2018 to March 2020. Two sets of Fine Needle Aspirate smears were obtained from breast lump and palpable lymph node, if present. Both sets of smear were air dried and fixed in propyl alcohol for 1-2 hours.First set of smear was used for cytology, in which cytology was positive, the second set of smear were packed in aluminum foil and preserved at -20 degree Celsius. Slides were then stained for ER and PR receptor. Later on when patient undergone surgery findings were correlated with histopathology. Results : The most common symptom was breast lump (87.5%) with tumour size of 2.0-5.0 cm. ER were positive in 65.0% cases, PR were positive in 57.5% and ER+/PR+ in 55.0% of cases.

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