Dosimetric comparison between intensity modulated radiotherapy and three-dimensional conformal radiotherapy in adjuvant setting after radical cystectomy in high-risk urothelial bladder cancer
Keywords:
Urothelial cancer, postoperative radiotherapy, Dosimetric study, IMRT, 3DCRTAbstract
Objective: To compare the 4-field 3D conformal radiotherapy technique (3DCRT) to the intensity-modulated radiotherapy (IMRT) 9-field technique for adjuvant radiotherapy post radical cystectomy in high-risk urothelial bladder cancer cases. Patients and Methods: A dosimetric analysis of 11 urothelial bladder cancer patients who underwent radical cystectomy was performed. These patients were presented to the radiotherapy department, National Cancer Institute, Cairo, between 2018 and 2020 with adjuvant radiotherapy using the IMRT technique. Two plans were designed for each patient, one using 9-field IMRT and the second using 4-field 3DCRT. The two techniques were compared, including the PTV, bowel bag, rectum, neobladder, and pelvic bone marrow. Results: Comparing different DVHs, the planning target volume (PTV) was adequately covered in both plans, while the 9-field IMRT technique delivered significantly lower doses to OARs (bowel, rectum, and pelvic bone marrow). Conclusion: The IMRT technique incredibly spared the OARs more than that obtained by the 3DCRT technique, while both techniques covered the PTV adequately. The IMRT technique, through sparing OARs, was expected to decrease early and late radiation side effects.
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Baumann, B. C., Noa, K., Wileyto, E. P., Bekelman, J. E., Deville, C., Vapiwala, N., Kirk, M., Both, S., Dolney, D., Kassaee, A., & Christodouleas, J. P. (2015). Adjuvant radiation therapy for bladder cancer: A dosimetric comparison of techniques. Medical Dosimetry, 40(4), 372–377. https://doi.org/10.1016/j.meddos.2015.06.001
Cagiannos, I., & Morash, C. (2009). Surveillance strategies after definitive therapy of invasive bladder cancer. Journal of the Canadian Urological Association, 3(6 SUPPL. 4), 237–242. https://doi.org/10.5489/cuaj.1205
Chan, P., Yeo, I., Perkins, G., Fyles, A., & Milosevic, M. (2006). Dosimetric comparison of intensity-modulated, conformal, and four-field pelvic radiotherapy boost plans for gynecologic cancer: a retrospective planning study. Radiation Oncology, 1(1), 13. https://doi.org/10.1186/1748-717X-1-13
Fonteyne, V., Dirix, P., Van Praet, C., Berghen, C., Albersen, M., Junius, S., Liefhooghe, N., Noé, L., De Meerleer, G., Ost, P., Villeirs, G., Verbeke, S., De Maeseneer, D., Rammant, E., Verghote, F., Elhaseen, E., De Man, K., & Decaestecker, K. (2021). Adjuvant Radiotherapy After Radical Cystectomy for Patients with High-risk Muscle-invasive Bladder Cancer: Results of a Multicentric Phase II Trial. European Urology Focus, xxxx. https://doi.org/10.1016/j.euf.2021.11.004
Forrest, J., Presutti, J., Davidson, M., Hamilton, P., Kiss, A., & Thomas, G. (2012). A Dosimetric Planning Study Comparing Intensity-modulated Radiotherapy with Four-field Conformal Pelvic Radiotherapy for the Definitive Treatment of Cervical Carcinoma. Clinical Oncology, 24(4), e63–e70. https://doi.org/10.1016/j.clon.2011.06.008
Gandhi, A. K., Sharma, D. N., Rath, G. K., Julka, P. K., Subramani, V., Sharma, S., Manigandan, D., Laviraj, M. A., Kumar, S., & Thulkar, S. (2013). Early Clinical Outcomes and Toxicity of Intensity Modulated Versus Conventional Pelvic Radiation Therapy for Locally Advanced Cervix Carcinoma: A Prospective Randomized Study. International Journal of Radiation Oncology*Biology*Physics, 87(3), 542–548. https://doi.org/10.1016/j.ijrobp.2013.06.2059
Gregoire, V., & Mackie, T. R. (2011). Dose prescription , reporting and recording in intensity-modulated radiation therapy : a digest of the ICRU Report 83. 3, 367–373.
Herr, H. W., Faulkner, J. R., Grossman, H. B., Natale, R. B., deVere White, R., Sarosdy, M. F., & Crawford, E. D. (2004). No Title. Journal of Clinical Oncology, 22(14), 2781–2789. https://doi.org/10.1200/JCO.2004.11.024
Klopp, A. H., Moughan, J., Portelance, L., Miller, B. E., Salehpour, M. R., Hildebrandt, E., Nuanjing, J., D’Souza, D., Souhami, L., Small, W., Gaur, R., & Jhingran, A. (2013). Hematologic Toxicity in RTOG 0418: A Phase 2 Study of Postoperative IMRT for Gynecologic Cancer. International Journal of Radiation Oncology*Biology*Physics, 86(1), 83–90. https://doi.org/10.1016/j.ijrobp.2013.01.017
Lee, N. Y., Riaz, N., & Lu, J. J. (Eds.). (2015). Target Volume Delineation for Conformal and Intensity-Modulated Radiation Therapy. Springer International Publishing. https://doi.org/10.1007/978-3-319-05726-2
Marks, L. B., Yorke, E. D., Jackson, A., Ten Haken, R. K., Constine, L. S., Eisbruch, A., Bentzen, S. M., Nam, J., & Deasy, J. O. (2010). Use of Normal Tissue Complication Probability Models in the Clinic. International Journal of Radiation Oncology Biology Physics, 76(3 SUPPL.). https://doi.org/10.1016/j.ijrobp.2009.07.1754
Mundt, A. J., Mell, L. K., & Roeske, J. C. (2003). Preliminary analysis of chronic gastrointestinal toxicity in gynecology patients treated with intensity-modulated whole pelvic radiation therapy. International Journal of Radiation Oncology*Biology*Physics, 56(5), 1354–1360. https://doi.org/10.1016/S0360-3016(03)00325-0
Pötter, R., Tanderup, K., Kirisits, C., de Leeuw, A., Kirchheiner, K., Nout, R., Tan, L. T., Haie-Meder, C., Mahantshetty, U., Segedin, B., Hoskin, P., Bruheim, K., Rai, B., Huang, F., Van Limbergen, E., Schmid, M., Nesvacil, N., Sturdza, A., Fokdal, L., … Jürgenliemk-Schulz, I. (2018). The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies. Clinical and Translational Radiation Oncology, 9, 48–60. https://doi.org/10.1016/j.ctro.2018.01.001
Reisinger, S. A., Mohiuddin, M., & Mulholland, S. G. G. (1992). Combined pre- and postoperative adjuvant radiation therapy for bladder cancer-A ten year experience. International Journal of Radiation Oncology, Biology, Physics, 24(3), 463–468. https://doi.org/10.1016/0360-3016(92)91060-Z
Rose, B. S., Aydogan, B., Liang, Y., Yeginer, M., Hasselle, M. D., Dandekar, V., Bafana, R., Yashar, C. M., Mundt, A. J., Roeske, J. C., & Mell, L. K. (2011). Normal Tissue Complication Probability Modeling of Acute Hematologic Toxicity in Cervical Cancer Patients Treated With Chemoradiotherapy. International Journal of Radiation Oncology*Biology*Physics, 79(3), 800–807. https://doi.org/10.1016/j.ijrobp.2009.11.010
Skinner, E. C., Stein, J. P., & Skinner, D. G. (2007). Surgical benchmarks for the treatment of invasive bladder cancer. Urologic Oncology: Seminars and Original Investigations, 25(1), 66–71. https://doi.org/10.1016/j.urolonc.2006.05.010
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937
Thaib, P. K. P., & Rahaju, A. S. (2022). Clinicopathological profile of clear cell renal cell carcinoma. International Journal of Health & Medical Sciences, 5(1), 91-100. https://doi.org/10.21744/ijhms.v5n1.1846
Verghote, F., Sargos, P., Christodouleas, J. P., Murthy, V., Baumann, B. C., Dirix, P., Berghen, C., Paelinck, L., Vercauteren, T., & Fonteyne, V. (2022). International Consensus Guidelines for Adjuvant Radiation Therapy for Bladder Cancer After Radical Cystectomy: Update From an IBIS Workgroup. Practical Radiation Oncology. https://doi.org/10.1016/j.prro.2022.05.014
Yang, B., Zhu, L., Cheng, H., Li, Q., Zhang, Y., & Zhao, Y. (2012). Dosimetric comparison of intensity modulated radiotherapy and three-dimensional conformal radiotherapy in patients with gynecologic malignancies: a systematic review and meta-analysis. Radiation Oncology, 7(1), 197. https://doi.org/10.1186/1748-717X-7-197
Zaghloul, M. S. (2010). Adjuvant and neoadjuvant radiotherapy for bladder cancer: Revisited. Future Oncology, 6(7), 1177–1191. https://doi.org/10.2217/fon.10.82
Zaghloul, M. S., Awwad, H. K., Akoush, H. H., Omar, S., Soliman, O., & Attar, E. L. (1992). Postoperative Radiotherapy Of Carcinoma In Bilharzial Bladder: Improved Disease Free Survival Through Improving Local Control. In Radiation Oncology Bid. Phys (Vol. 23).
Zaghloul, M. S., Christodouleas, J. P., Smith, A., Abdallah, A., William, H., Khaled, H. M., Hwang, W. T., & Baumann, B. C. (2018). Adjuvant sandwich chemotherapy plus radiotherapy vs adjuvant chemotherapy alone for locally advanced bladder cancer after radical cystectomy a randomized phase 2 trial. JAMA Surgery, 153(1). https://doi.org/10.1001/jamasurg.2017.4591
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