Synergism effect of iron nanoparticles with Ocimum Basilicum L. on breast cancer cell

https://doi.org/10.53730/ijhs.v6nS4.11961

Authors

  • Mohammed Qasim Alasheqi National University of Science And Technology/ Collage Of Pharmacy
  • Jwan A. Zainulabdeen University Of Baghdad/ Faculty of Science

Keywords:

breast cancer, cell line, basil, iron nanoparticle

Abstract

Breast cancer is the second leading cause of cancer deaths among women. The development of breast cancer is a multi-step process involving multiple cell types, and its prevention remains challenging in the world. Early diagnosis of breast cancer is one of the best approaches to prevent this disease. In some developed countries, the 5-year relative survival rate of breast cancer patients is above 80% due to early prevention. For people presenting without metastatic disease, therapeutic goals are tumor eradication and preventing recurrence. Ocimum basilicum L. (Basil) is a plant that has a place with the family Labiatae, also basil leave have activities intense cancer prevention agents, curbs aging, is an anticancer, antiviral, and has antimicrobial properties. This study aimed to determine effect of nanotechnology with basil as synergism effect on breast cancer cell also showing the side effect of treatment on normal cells. In this work breast cancer cells (MDA and MCF7) was treated with Iron nanoparticle that prepared by Cold Atmospheric Plasma (CAP) and Ocimum Basilcum L. (Basil) as synergism effect on the cells. 

Downloads

Download data is not yet available.

References

A. B. A. Mohammed et al., “Chemical profile, antiproliferative, antioxidant and enzyme inhibition activities of Ocimum basilicum L. and Pulicaria undulata (L.) CA Mey. grown in Sudan,” South African J. Bot., vol. 132, pp. 403–409, 2020.

Á. Calín-Sánchez, K. Lech, A. Szumny, A. Figiel, and Á. A. Carbonell-Barrachina, “Volatile composition of sweet basil essential oil (Ocimum basilicum L.) as affected by drying method,” Food Res. Int., vol. 48, no. 1, pp. 217–225, 2012.

A. Cvetanović et al., “Chemical and biological insights on aronia stems extracts obtained by different extraction techniques: From wastes to functional products,” J. Supercrit. Fluids, vol. 128, pp. 173–181, 2017, doi: 10.1016/j.supflu.2017.05.023.

A. F. Ahmed, F. A. K. Attia, Z. Liu, C. Li, J. Wei, and W. Kang, “Antioxidant activity and total phenolic content of essential oils and extracts of Sweet basil (Ocimum basilicum L.) plants,” Food Sci. Hum. Wellness, vol. 8, no. 3, pp. 299–305, 2019.

A. Hamil, K. M. Khalifa, A. A. Almutaleb, and M. Q. Nouradean, “Synthesis, Characterization and Antibacterial Activity Studies of Some Transition Metal Chelates of Mn(II), Ni(II) and Cu(II) with Schiff Base Derived from Diacetylmonoxime with O-phenylenediamine,” Adv. J. Chem. A, vol. 3, no. 4, pp. 524–533, 2020, doi: 10.33945/SAMI/AJCA.2020.4.13.

A. Joshi, O. Prakash, A. K. Pant, R. Kumar, L. Szczepaniak, and K. Kucharska-Ambrożej, “Methyl Eugenol, 1, 8-Cineole and Nerolidol Rich Essential Oils with their Biological Activities from three Melaleuca Species Growing in Tarai Region of North India,” Brazilian Arch. Biol. Technol., vol. 64, 2022.

A. M. Hamza, “Newcastle disease Virus therapy for transplanted tumors in combination with chemotherapy.” Ph. D. Thesis, Collage of Veterinary Medicine, University of Baghdad, 2009.

A. Sharma, “Design Of Modified 2-Dimesional Mechanism For Various Operations In Peppermint Plant For Rural India,” 2021.

C. S. Alaribe, M. Lawal, R. Momoh, U. Idaholo, P. Mudabai, and A. A. Adejare, “Phytochemical and Toxicological Properties of Sclerotium from the Edible Fungus-Pleurotus tuber-regium. Trop J Nat Prod Res. 2018; 2 (5): 235-239. doi. org/10.26538/tjnpr/v2i5. 6 2018 Natural Product Research Group, Faculty of Pharmacy, University of Beni,” All rights Reserv. Isol. from fungi fruiting bodies Incl.

D. M. Parkin and L. M. G. Fernández, “Use of statistics to assess the global burden of breast cancer,” Breast J., vol. 12, pp. S70–S80, 2006.

E. Manaloto et al., “Cold atmospheric plasma induces silver nanoparticle uptake, oxidative dissolution and enhanced cytotoxicity in glioblastoma multiforme cells,” Arch. Biochem. Biophys., vol. 689, p. 108462, 2020.

Eviasty, N., Daud, N. A., Hidayanty, H., Hadju, V., Maddeppungeng, M., & Bahar, B. (2021). The effect of personal coaching on increasing knowledge, attitudes, and actions about lactation nutrition, uterial involution, and lochea in public mothers. International Journal of Health & Medical Sciences, 4(1), 155-163. https://doi.org/10.31295/ijhms.v4n1.1669

F. V. Moghadam, R. Pourahmad, A. Mortazavi, D. Davoodi, and R. Azizinezhad, “Use of Fish Oil Nanoencapsulated with Gum Arabic Carrier in Low Fat Probiotic Fermented Milk,” Food Sci. Anim. Resour., vol. 39, no. 2, pp. 309–323, Apr. 2019, doi: 10.5851/kosfa.2019.e25.

G. N. Hortobagyi et al., “The global breast cancer burden: variations in epidemiology and survival,” Clin. Breast Cancer, vol. 6, no. 5, pp. 391–401, 2005.

J. Bassaganya-Riera, R. Hontecillas, and M. J. Wannemuehler, “Nutrition impact of conjugated linoleic acid: A model functional food ingredient,” Vitr. Cell. Dev. Biol., vol. 38, no. 3, pp. 241–246, 2002.

J. Ferley, I. Soerjomataram, and M. Ervik, “Cancer incidence and mortality worldwide: IARC CancerBase No,” 2013.

K. Bączek, O. Kosakowska, M. Gniewosz, I. Gientka, and Z. Węglarz, “Sweet basil (Ocimum basilicum L.) productivity and raw material quality from organic cultivation,” Agronomy, vol. 9, no. 6, p. 279, 2019.

K. J. Walters and R. G. Lopez, “Hydroponic Basil Production: Temperature Influences Volatile Organic Compound Profile, but Not Overall Consumer Preference,” Horticulturae, vol. 8, no. 1, p. 76, 2022.

K. S. Silva-Alves et al., “Estragole blocks neuronal excitability by direct inhibition of Na+ channels,” Brazilian J. Med. Biol. Res. = Rev. Bras. Pesqui. medicas e Biol., vol. 46, no. 12, pp. 1056–1063, Dec. 2013, doi: 10.1590/1414-431X20133191.

M. A. Alkhateeb et al., “Low-temperature extracts of Purple blossoms of basil (Ocimum basilicum L.) intervened mitochondrial translocation contributes prompted apoptosis in human breast cancer cells,” Biol. Res., vol. 54, 2021.

M. K. Swamy, G. Arumugam, R. Kaur, A. Ghasemzadeh, M. M. Yusoff, and U. R. Sinniah, “GC-MS Based Metabolite Profiling, Antioxidant and Antimicrobial Properties of Different Solvent Extracts of Malaysian Plectranthus amboinicus Leaves,” Evidence-Based Complement. Altern. Med., vol. 2017, p. 1517683, 2017, doi: 10.1155/2017/1517683.

M. Patel, R. Lee, E. V Merchant, H. R. Juliani, J. E. Simon, and B. J. Tepper, “Descriptive aroma profiles of fresh sweet basil cultivars (Ocimum spp.): Relationship to volatile chemical composition,” J. Food Sci., vol. 86, no. 7, pp. 3228–3239, 2021.

M. Zahid, M. Arif, M. A. Rahman, K. Singh, and M. Mujahid, “Solvent Extraction and Gas Chromatography–Mass Spectrometry Analysis of Annona squamosa L. Seeds for Determination of Bioactives, Fatty Acid/Fatty Oil Composition, and Antioxidant Activity,” J. Diet. Suppl., vol. 15, no. 5, pp. 613–623, Sep. 2018, doi: 10.1080/19390211.2017.1366388.

M. Zendehdel, B. Niakan, A. Keshtkar, E. Rafiei, and F. Salamat, “Subtypes of benign breast disease as a risk factor for breast cancer: A systematic review and meta-analysis protocol,” Iran. J. Med. Sci., vol. 43, no. 1, p. 1, 2018.

N. Dhar et al., “Characterization of a sweet basil acyltransferase involved in eugenol biosynthesis,” J. Exp. Bot., vol. 71, no. 12, pp. 3638–3652, Jun. 2020, doi: 10.1093/jxb/eraa142.

P. Thiviya, A. Gamage, D. Piumali, O. Merah, and T. Madhujith, “Apiaceae as an Important Source of Antioxidants and Their Applications,” Cosmetics , vol. 8, no. 4. 2021, doi: 10.3390/cosmetics8040111.

R. G. Torres et al., “Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway,” J. Bioenerg. Biomembr., vol. 50, no. 2, pp. 93–105, 2018.

R. K. Ahmad, K. F. Dizaye, and A. A. AL-Asady, “Cytotoxic Effects of Pistacia khinjuk Seed Extracts on Different Cell Lines and its Mitogenic Effects on Blood Lymphocyte In Vitro,” Cihan Univ. Sci. J., vol. 4, no. 1, pp. 13–20, 2020, doi: 10.24086/cuesj.v4n1y2020.pp13-20.

R. K. Gupta, D. Kumari, and A. K. Saxena, “Antiproliferative and Antioxidant effect of Ocimum tenuiflorum leaves extract on Breast cancer cell lines: In vitro study,” Ann. Rom. Soc. Cell Biol., vol. 25, no. 6, pp. 6433–6442, 2021.

S. Guram et al., “Multidisciplinary intervention in radiation-associated angiosarcoma of the breast: patterns of recurrence and response to treatment,” Ann. Surg. Oncol., vol. 29, no. 1, pp. 522–532, 2022.

S. Nautiyal, K. C. Smitha, and H. Kaechele, “Medicinal plant biodiversity in India: harnessing opportunities for promoting livelihood and food security,” in Socio-economic and Eco-biological Dimensions in Resource use and Conservation, Springer, 2020, pp. 135–169.

S. R. Hindi, “on Gene Expression of Newcastle Disease Virus,” vol. 5, no. 11, 2017.

S. Wang, H. Chen, and B. Sun, “Recent progress in food flavor analysis using gas chromatography–ion mobility spectrometry (GC–IMS),” Food Chem., vol. 315, p. 126158, 2020.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2022). Post-pandemic health and its sustainability: Educational situation. International Journal of Health Sciences, 6(1), i-v. https://doi.org/10.53730/ijhs.v6n1.5949

T. Shiratori et al., “Singular value decomposition analysis of the secondary structure features contributing to the circular dichroism spectra of model proteins,” Biochem. Biophys. Reports, vol. 28, p. 101153, 2021, doi: https://doi.org/10.1016/j.bbrep.2021.101153.

V. Suryawanshi, “Extraction and isolation of clerodane as a bioactive molecule from Tragia ramosa,” J. Pharmacogn. Phytochem, vol. 8, pp. 1135–1138, 2019.

Z. S. Alshlmany, “Histopathological study of breast cancer in Libyan Patients in eastern region between years (2015 to 2018),” 2019.

Published

21-08-2022

How to Cite

Alasheqi, M. Q., & Zainulabdeen, J. A. (2022). Synergism effect of iron nanoparticles with Ocimum Basilicum L. on breast cancer cell. International Journal of Health Sciences, 6(S4), 9255–9268. https://doi.org/10.53730/ijhs.v6nS4.11961

Issue

Section

Peer Review Articles