Evaluation of serum magnesium levels in patients with acute myocardial infarction
Keywords:
MI, CAD, magnesium, acute myocardial infarctionAbstract
Aim: To evaluate the serum magnesium levels in patients with acute myocardial infarction. Material and method: The present prospective observational study was conducted in the department of Medicine among 50 patients with acute myocardial infarction. Patients who presented to the hospital within 24 hours of onset of symptoms and diagnosed with acute myocardial infarction were included in the study. Blood samples collection were taken within 24 hours of onset of symptoms. All patients were evaluated for their ECG and cardiac enzymes and serum magnesium level by taking 5 cc venous blood sample in a disposable syringe and sent to biochemistry laboratory for analysis in fluoride bulb and plain bulb respectively. Results: Smoking was reported in 82% of the subjects whereas hypertension and diabetes mellitus in 64% and 46% of the subjects respectively. Sixteen percent, 24% and 60% of the subject’s time of presentation was 3-6 hours, 6-12 hours and 12-18 hours respectively. On day 5, only six percent (3) of the subjects with arrhythmia were having serum magnesium level (mg/dL) <1.6 while 14% of the subjects with arrhythmia reported 1.7-2.4 serum magnesium level (mg/dL). There was an increase in serum magnesium from Day-1 to Day-5 with statistically significant difference.
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Abraham AS, Eylath U, Weinstein M, Czaczkes E. Serum magnesium levels in patients with acute myocardial infarction. N Engl J Med 1977; 296: 862–3.
Adamopoulos C, Pitt B, Sui X, Love TE, Zannad F, Ahmed A. Low serum magnesium and cardiovascular mortality in chronic heart failure: A propensity-matched study. Int J Cardiol 2009;136:270-7.
Boon NA, Fox KAA, Bloomfield P, Brad BA: Cardiovascular disease in Davidson’s Principles and practice of Medicine, 19th Edition, Churchill Living Stone, 2002, Pg. 420, 422, 424, 441, 443.
Del Gobbo LC, Imamura F, Wu JH, de Oliveira Otto MC, Chiuve SE, Mozaffarian D. Circulating and dietary magnesium and risk of cardiovascular disease: A systematic review and meta-analysis of prospective studies. Am J Clin Nutr 2013;98:160-73.
Dyckner T. Serum magnesium in acute myocardial infarction. Relation to arrhythmias. Acta Med Scand 1980;207:59-66.
Elin RJ. Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol 1994; 102: 616–22.
Kafka H, Langevin L, Armstrong PW. Serum magnesium and potassium in acute myocardial infarction: influence on ventricular arrhythmias. Archives of internal medicine. 1987;147(3):465-9.
Karki MA, Balasubramaniyan S, Prabhu G, Barath J. Study of serum magnesium level in patients with acute myocardial infarction at presentation and its prognostic correlation. Int J Modn Res Revs 2015;3(10):945-47.
Kedarnath KK, Sikki BK. Sur: Serum magnesium in clinical experimental myocardial infarction, Ind Jour Med Res ;57(2):317-323.
Khan GQ, Mohammad G, Hassan G. Study of serum magnesium in acute myocardial infarction. J Asso Phys Ind Jan 2002; 50(101).
Liamis G, Rodenburg EM, Hofman A, Zietse R, Stricker BH, Hoorn EJ. Electrolyte disorders in community subjects: Prevalence and risk factors. Am J Med 2013;126:256-63.
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2224–60.
Maier JA: Endothelial cells and magnesium: implications in atherosclerosis. Clin Sci (Lond) 2012; 122: 397–407.
Mohan G, Jain VK. Serum magnesium; a prognostic tool of acute myocardial infarction. Indian J Physiol Pharmacol 1994; 38 (4); 294- 296.
Navarro-Gonzalez JF, Mora-Fernandez C, Garcia-Perez J: Clinical implications of disordered magnesium homeostasis in chronic renal failure and dialysis. Semin Dial 2009; 22:37–44.
Ratnawati, I. G. A. A., Suandayani, N. K. T., & Sutapa, G. N. (2019). The linearity of x-ray devices radiation output and its relationship with patient thickness. International Journal of Physical Sciences and Engineering, 3(3), 1–6. https://doi.org/10.29332/ijpse.v3n3.351
Reffelmann T, Dörr M, Ittermann T, Schwahn C, Völzke H, Ruppert J, Robinson D, Felix SB: Low serum magnesium concentrations predict increase in left ventricular mass over 5 years independently of common cardiovascular risk factors. Atherosclerosis 2010; 213:563–569.
Ryan MF. The role of magnesium in biochemistry: an overview. Ann Clin Biochem 1991; 28: 19–26.
Sathisha TG, Manjunatha GBK, Avinash SS, Shetty J, Devi OS, Devaki RN. Microalbunuria in non diabetic, non hypertensive myocardial infarction in south Indian patients with relation to lipid profile and cardiac markers. J Clin Diag Res 2011;5:1158–1160.
Seelig MS. Range of normal serum magnesium values. N Engl J Med 1974;290:974-975.
Sharma, N. (2015). Implementation of vendor managed inventory (VMI) in managing intraocular lenses (IOL) in eye care organization. International Research Journal of Management, IT and Social Sciences, 2(9), 1-9. Retrieved from https://sloap.org/journals/index.php/irjmis/article/view/317
Simmikharb, Singh V. Magnesium deficiency potentiates free radical production associated with myocardial infarction. J Asso Phys Ind 2000; 48; 484-485.
Stamler J. Epidemiology, established major risk factors and the primary presentation of coronary heart disease. In Chatterjee K, Cheitlin MP, Kaslines J et al (Eds) cardiology: an illustrated text, reference vol 2; 0-1 Philadelphia, JB Lippincott 1991.
Subramanyam NT, Vakrani GP. Serum magnesium in acute myocardial infarction. Journal of Evolution Of Medical And Dental Sciences-JEMDS. 2015;4(60):10460-7.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Venkateshwarlu M, Gayathri C. Study of significance of estimation of lipid profile in patient with acute myocardial infarction. Int J Inf Res Rev 2015;2:1028–1030.
Wannaslip N, Poungvarin N, Pokums. Seum magnesium in Thai coronary artery disease patients. J Med Assoc Thai 2001;84(3):5645-9.
Whang R, Dei TO, Aikawa J. Predictors of clinical hypomagnesaemia–hypokalaemia, hypophosphataemia, hypocalcaemia. Arch Intern Med 1984; 144: 1794–6.
Wong HKC. Fully automated procedure for serum magnesium. Clin Chern 1975; 21: 169.
Woods KL, Fletcher S. Long-term outcome after intravenous magnesium sulphate in suspected acute myocardial infarction: The second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1994;343:816-9.
Yogi A, Callera GE, O’Connor SE, He Y, Correa JW, Tostes RC, Mazur A, Touyz RM: Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone- induced hypertension and kidney damage in a model of hereditary hypomagnesemia. J Hypertens 2011; 29: 1400–1410.
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