Test the effectiveness of clove leaf ethanol extract on wound healing in rats

Puguh Santoso; I Made Agus Sunadi Putra; Ni Nyoman Wahyu Udayani

doi:10.53730/ijhs.v6nS5.12006

Authors

Puguh Santoso Faculty of Pharmacy, Mahasaraswati University Denpasar, Jalan Kamboja No.11A, Denpasar, Bali, 80231, Indonesia
I Made Agus Sunadi Putra Faculty of Pharmacy, Mahasaraswati University Denpasar, Jalan Kamboja No.11A, Denpasar, Bali, 80231, Indonesia
Ni Nyoman Wahyu Udayani Faculty of Pharmacy, Mahasaraswati University Denpasar, Jalan Kamboja No.11A, Denpasar, Bali, 80231, Indonesia

Keywords:

clove leaf extract, healing, ointment

Abstract

Clove leaves (Syzygium aromaticum (L.) Merr. & Perry) contain alkaloid compounds, flavonoids, tannins and essential oils that play a role in wound healing. This study used 20 male mice as samples divided into 4 treatment groups, namely group 1 (negative control group), group 2 (positive control group), group 3 (15% clove leaf extract ointment), and group 4 (leaf extract ointment). clove concentration 20%). All mice were injured 2 cm long. The results showed that there was a difference between the control and the clove leaf extract ointment at concentrations of 15% and 20%. In the Wilcoxon test the results showed a p value <0.05 where there was a treatment group. And for the Mann Whitney test the results showed that there were differences between the control group and the clove extract ointment. The p value for the three comparisons was only negative control with clove leaf extract ointment with a concentration of 15% and a concentration of 20% which was smaller than 0.05. So the hypothesis Ho is rejected, there is a difference between the negative control with clove leaf extract ointment with a concentration of 15% and 20%.

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